Herpes zoster after ChAdOx1 nCoV‐19 vaccine: a case series

Vastarella, Maria; Picone, Vincenzo; Fabbrocini, Gabriella; Fabbrocini, Gabriella

doi:10.1111/jdv.17576

Cited by 36 publications

(28 citation statements)

References 5 publications

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“…Duration from the vaccination to skin reaction ranged from 1 to 24 days with a mean of 6.75 days. This result is similar to the case series findings of 7.6 days (three cases) reported by Vastarella et al ( 2021 ) and 5.4 days (5 cases) reported by Rodríguez‐Jiménez et al ( 2021 ). The median time from hospitalization after COVID‐19 infection to HZ appearing was 5.5 days (Tartari et al, 2020 ).…”

Section: Discussionsupporting

confidence: 92%

“…Studies have shown that vaccines such as for hepatitis A, influenza, rabies, and Japanese encephalitis can trigger the reactivation of the HZ (Eid et al, 2021 ; Vastarella et al, 2021 ; Wollina et al, 2020 ; Wollina et al, 2021 ). Although the prognosis is predictable, the etiology and association with vaccines and VZV reactivation is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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A narrative review and clinical anatomy of herpes zoster infection following COVID‐19 vaccination

Iwanaga

Fukuoka

et al. 2021

Clinical Anatomy

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Introduction: In this review, cases of herpes zoster (HZ) infection following receipt of COVID-19 vaccines will be analyzed. We also present two cases of oral HZ following the COVID-19 vaccine and discuss this clinical anatomy.Materials and Methods: A database search using PubMed was conducted in August 2021 and 20 articles were found to be eligible for review. Patient data and vaccine information were analyzed. In addition, two cases of oral HZ infection following the receipt of COVID-19 vaccines are presented.Results: A total of 399 cases were identified. The affected dermatomes mimicked the regular distribution of HZ. For the dermatomes of the face, the various reports used different ways to describe the areas involved; CNV, CNV1, CNV2, CNV3, lower jaw, forehead, and under the eyebrow (CNV, 2 cases; CNV1, 4 cases; CNV2, 3 cases; and CNV3, 3 cases). Some patients who had a history of varicella zoster virus vaccination had HZ following the COVID-19 vaccination. Two patients with oral HZ following vaccination were found to have involvement of the greater palatine nerve.Conclusions: Vaccine-related HZ cases have been reported worldwide. Although many studies with a larger number of cases are ongoing, detailed information can be obtained from case reviews as reported herein.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

A narrative review and clinical anatomy of herpes zoster infection following COVID‐19 vaccination

Iwanaga

Fukuoka

et al. 2021

Clinical Anatomy

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“…Clinically, BCG inflammation presented as a painful, erythematous, and indurated plaque at the BCG scar site [73]. Several cases of herpes simplex virus (HSV) and varicella zoster virus (VZV) reactivation have been documented [6,7,[74][75][76][77]. In a large study of 405 cutaneous reactions, VZV and HSV reactivations were 10% and 3% of the cases, respectively.…”

Section: Flare Of Existing Dermatosesmentioning

confidence: 99%

Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines

Bellinato

Maurelli

Gisondi

et al. 2021

JCM

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Many patients are receiving SARS-CoV-2 vaccinations, which have been associated with a variety of adverse effects. Cutaneous adverse reactions to SARS-CoV-2 vaccinations have been progressively reported, but they have not been reviewed according to their morphological clinical patterns. The objective of this review was to summarize the existing data concerning the cutaneous adverse reactions following SARS-CoV-2 vaccines and group them according to common morphological and pathogenetic patterns. We reviewed the English language literature up to 15 August 2021, using predefined keywords to identify the relevant studies evaluating cutaneous adverse reactions associated with SARS-CoV-2 vaccines. We search for recurrent morphological patterns sharing clinical signs and symptoms and physio-pathological mechanisms. Timing to onset following the first or booster dose of the vaccine, predisposing conditions, therapeutic management, and outcome were also collected. Among the dermatological manifestations associated with SARS-CoV-2 vaccinations, we distinguished: (1) new onset reactions and (2) flares of preexisting dermatoses. The most common were injection site reactions, affecting 30–70% and generally mild or moderate. Small case series or single case reports included filler reactions, exanthemas, vascular lesions, urticaria, eczematous dermatitis, autoimmune bullous reactions, and severe cutaneous adverse reactions. In addition, the exacerbation of chronic immuno-mediated dermatoses (mainly psoriasis and atopic dermatitis) and reactivations of herpes infection were reported. The cutaneous reactions were generally mild, self-limiting, and resembled common cutaneous drug eruptions and/or COVID-19 skin manifestations.

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“…An alternative etiology cannot be ruled out since zoster reactivation is documented in COVID patients without vaccination ( 4 ). But, the timing and similarity to VAERS reports, other vaccines associated with varicella reactivation ( 5 ), and a lack of alternative explanations align with the criteria ( 6 ) for “probable/likely.” Since my episode, the same association has been posited by physicians in Turkey ( 7 ), Italy ( 8 ), and the United States ( 9 ). Physicians at a dermatology practice in Nevada, United States of America, also reported a spate of shingles cases reported to them on their social media accounts, following a television news report ( 10 ).…”

mentioning

confidence: 60%

Countering Hesitancy and Misinformation on Side Effects to Complete the Course of COVID Vaccination

Dasgupta

2021

Journal of Patient Experience

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It has been well-documented that concerns about side effects prevent many from soliciting immunization. And family medicine providers play a key role in addressing concerns about COVID vaccines. However, there are few documented examples of the decision-making process regarding second shots after the emergence of a concerning and previously unknown side effect. Therefore, we present a case where a primary care provider and patient worked together to analyze real-time adverse event data on post-vaccination shingles to decide whether to receive the second dose.

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Herpes zoster after ChAdOx1 nCoV‐19 vaccine: a case series

Cited by 36 publications

References 5 publications

A narrative review and clinical anatomy of herpes zoster infection following COVID‐19 vaccination

A narrative review and clinical anatomy of herpes zoster infection following COVID‐19 vaccination

Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines

Countering Hesitancy and Misinformation on Side Effects to Complete the Course of COVID Vaccination

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