Herpes Simplex Virus 2–Associated Hemophagocytic Lymphohistiocytosis in a Pregnant Patient

Abstract

It is often important to take into consideration hemophagocytic lymphohistiocytosis when encountering cytopenia with high-grade fever. Cyclosporin A was a safe and available strategy for this corticosteroid-resistant case.

Severe Kaposi's varicelliform eruption in mild atopic dermatitis complicated by rhabdomyolysis: A case report

“…6 It is rare, but HSV infection in severe AD patients can lead to multiorgan complications, such as rhabdomyolysis, hemophagocytic syndrome, and encephalitis. 4,[7][8][9] In this case, however, mild AD leaded to KVE and even rhab- F I G U R E 1 A, Clinical presentation on the initial visit. Widespread erosion, crusts, and swelling were seen over the scalp, face, neck, upper trunk and proximal upper arm.…”

Triple threat: pregnancy, SLE, EBV as potential triggers in secondary hemophagocytic lymphohistiocytosis

“…8 This decrease in cell mediated immunity has been hypothesized to be responsible for the excessive activation of lymphohistiocytes, a Th2 response as opposed to the normal Th1 response. 26,27 This may lead to immune activation scenarios such as HLH.…”

Pregnancy-related hemophagocytic lymphohistiocytosis associated with cytomegalovirus infection: A diagnostic and therapeutic challenge

“…This will result in relatively decreased cell-mediated immunity (CMI) by Th1 cells with increased susceptibility to viral infections [23]. Yamaguchi et al [8] hypothesized that the decreased CMI may allow the overactivation of hemophagocytes as the first immune response to infection instead of Th1 immune response. These stimulated and uncontrolled macrophages also rapidly produce tissue necrosis factor a, which initiates the inflammatory effector pathway.…”