Herpes gestationis in association with a hydatidiform mole. Immunopathologic studies

Tindall, J. G.

doi:10.1001/archderm.117.8.510

Cited by 18 publications

(8 citation statements)

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“…1,3,4 In a small number of cases, the disease can be a paraneoplastic manifestation of trophoblastic tumors, hydatiform mole, or choriocarcinoma. 5,6 It sometimes relapses with the onset of menses or use of oral contraceptives postpartum but quickly remits after their discontinuation. 4,7,8 In PG, an immune response against the hemidesmosomal protein BP180, also designated as type XVII collagen or BPAG2, is executed.…”

Section: Epidemiology and Clinical Presentationmentioning

confidence: 99%

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Sadik

Lima

Zillikens

2016

Clinics in Dermatology

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Section: Epidemiology and Clinical Presentationmentioning

confidence: 99%

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Sadik

Lima

Zillikens

2016

Clinics in Dermatology

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“…Four previous cases in which PG coincided with a hydatidiform mole have been reported [9–12]. A summary of these cases and our patient is presented in Table 2.…”

Section: Discussionmentioning

confidence: 68%

“…PG is a perinatal, autoimmune, pruritic, and vesiculobullous skin disorder, pathophysiologically resembling bullous pemphigoid. PG also occurs in moles [9–12] and choriocarcinomas [13, 14]. PG should be differentiated from several perinatal pruritic dermatoses such as pruritic urticarial papules and plaques of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole

Matsumoto¹,

Osada

Kaneko³

et al. 2013

Case Reports in Obstetrics and Gynecology

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Pemphigoid gestationis (PG) is a rare, perinatal, autoimmune, and blistering dermatosis. Only few cases of PG involving hydatidiform moles have been reported. Complete hydatidiform moles are usually evacuated by dilatation and curettage. We report a patient with a massive complete hydatidiform mole that underwent spontaneous expulsion; she subsequently developed PG. A 19-year-old unmarried nulligravid woman was referred to our hospital following excessive vaginal bleeding after an uncertain amenorrheal period. The patient presented with preshock vital signs, severe anemia, and a positive urine pregnancy test. Imaging examinations revealed a massive intrauterine mass (19 × 15 × 10 cm), suggesting a complete hydatidiform mole. She was hospitalized and treated with blood transfusion. Sixteen hours after hospitalization, the massive molar mass underwent spontaneous expulsion and bleeding ceased. Three days after the expulsion, she developed pruritic skin lesions including papules, erythemas, and bullae, which spread over her entire body. Skin biopsy revealed PG and subepidermal blister formation and linear complement C3 deposition along the basement membrane zone, and the serum anti-BP180 antibody level was found to be high on measurement. She was effectively treated with 50 mg/day of oral prednisolone. Her skin lesions disappeared, leaving pigmentation.

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“…1,2,6,7,9 Pemphigoid gestationis can also occur as a paraneoplastic syndrome in association with choriocarcinoma or hydatidiform mole. 13,14 The initial lesions of PUPPP tend to occur in striae and spare the umbilicus, whereas pemphigoid gestationis often begins in the periumbilical area. 1,2,7,9,15 Early and nonbullous forms of pemphigoid gestationis can be urticarial in appearance, but most lesions of pemphigoid gestationis tend to progress and often eventuate with the formation of tense bullae greater than 1 cm in diameter.…”

Section: Commentmentioning

confidence: 99%