Heritability of Plasma Cortisol

Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study

“…Individual differences in both human cortisol output (Bartels et al, 2003; Kirschbaum et al, 1992; Levene et al, 1972; Meikle et al, 1988), and brain structure (Schmitt et al, 2007) are influenced by genetic factors to varying degrees, but we are unaware of any examination of the genetic relationship between cortisol and brain structure. In the present study, we sought to examine the relationship of cortisol levels and brain structure in a large sample that is representative of U.S. men in the age range under study.…”

Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study

“…Individual differences in both human cortisol output (Bartels et al, 2003; Kirschbaum et al, 1992; Levene et al, 1972; Meikle et al, 1988), and brain structure (Schmitt et al, 2007) are influenced by genetic factors to varying degrees, but we are unaware of any examination of the genetic relationship between cortisol and brain structure. In the present study, we sought to examine the relationship of cortisol levels and brain structure in a large sample that is representative of U.S. men in the age range under study.…”

Pharmacogenetics of Asthma Therapy

“…In addition, it has been hypothesized that endogenous GC levels affect the response to corticosteroids [91]. A number of twin and family studies have demonstrated that endogenous levels of GCs in plasma are heritable [92][93][94][95][96][97][98].…”

Overview of the pharmacogenetics of asthma treatment

“…2 In corticosteroid therapy, a number of family and twin studies have demonstrated consistent evidence that endogenous levels of glucocorticoids (GC), usually measured as plasma cortisol levels at certain times of the day, are heritable. [4][5][6][7][8] We have generated similar heritability data for bronchodilator response in a Chinese population. 9 As the initial sequence of the human genome was published, 10,11 the concept that genetic variation will allow prediction of treatment response has been seen as an important and achievable goal.…”

Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study

“…Individual differences in both human cortisol output (Bartels et al, 2003; Kirschbaum et al, 1992; Levene et al, 1972; Meikle et al, 1988), and brain structure (Schmitt et al, 2007) are influenced by genetic factors to varying degrees, but we are unaware of any examination of the genetic relationship between cortisol and brain structure. In the present study, we sought to examine the relationship of cortisol levels and brain structure in a large sample that is representative of U.S. men in the age range under study.…”

Pharmacogenetics of Asthma Therapy

“…In addition, it has been hypothesized that endogenous GC levels affect the response to corticosteroids [91]. A number of twin and family studies have demonstrated that endogenous levels of GCs in plasma are heritable [92][93][94][95][96][97][98].…”

Overview of the pharmacogenetics of asthma treatment

“…2 In corticosteroid therapy, a number of family and twin studies have demonstrated consistent evidence that endogenous levels of glucocorticoids (GC), usually measured as plasma cortisol levels at certain times of the day, are heritable. [4][5][6][7][8] We have generated similar heritability data for bronchodilator response in a Chinese population. 9 As the initial sequence of the human genome was published, 10,11 the concept that genetic variation will allow prediction of treatment response has been seen as an important and achievable goal.…”

Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study

“…Individual differences in both human cortisol output (Bartels et al, 2003; Kirschbaum et al, 1992; Levene et al, 1972; Meikle et al, 1988), and brain structure (Schmitt et al, 2007) are influenced by genetic factors to varying degrees, but we are unaware of any examination of the genetic relationship between cortisol and brain structure. In the present study, we sought to examine the relationship of cortisol levels and brain structure in a large sample that is representative of U.S. men in the age range under study.…”

Pharmacogenetics of Asthma Therapy

“…In addition, it has been hypothesized that endogenous GC levels affect the response to corticosteroids [91]. A number of twin and family studies have demonstrated that endogenous levels of GCs in plasma are heritable [92][93][94][95][96][97][98].…”

Overview of the pharmacogenetics of asthma treatment

“…2 In corticosteroid therapy, a number of family and twin studies have demonstrated consistent evidence that endogenous levels of glucocorticoids (GC), usually measured as plasma cortisol levels at certain times of the day, are heritable. [4][5][6][7][8] We have generated similar heritability data for bronchodilator response in a Chinese population. 9 As the initial sequence of the human genome was published, 10,11 the concept that genetic variation will allow prediction of treatment response has been seen as an important and achievable goal.…”