2005
DOI: 10.1007/s00280-004-0960-5 View full text |Buy / Rent full text
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Abstract: HERG expression levels and chemosensitivity were positively correlated for vincristine, paclitaxel, and hydroxy-camptothecin. Erythromycin was active as a modulator. These results suggest that HERG may serve as a molecular marker and modulating target for individualized cancer therapy.

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“…Chen et al (28) reported that A549 cells expressing low levels of HERG were less sensitive than HT-29 cells expressing high levels of HERG to vincristine, paclitaxel and hydroxy-camptothecin. The chemosensitivities of HERG-transfected A549 cells to vincristine, paclitaxel and hydroxy-camptothecin were significantly increased, compared to parent A549 cells.…”
Section: Discussionmentioning
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“…Chen et al (28) reported that A549 cells expressing low levels of HERG were less sensitive than HT-29 cells expressing high levels of HERG to vincristine, paclitaxel and hydroxy-camptothecin. The chemosensitivities of HERG-transfected A549 cells to vincristine, paclitaxel and hydroxy-camptothecin were significantly increased, compared to parent A549 cells.…”
Section: Discussionmentioning
“…The human ether-a-go-go related gene (HERG) that encodes a delayed rectifier K + channel was shown to promote H 2 O 2 -induced apoptosis in a variety of tumor cells expressing this channel, in direct contrast to cells that lacked HERG expression [51]. Additionally, cell lines with high HERG potassium channel expression have been shown to be more sensitive to chemotherapeutic drugs than cells with a lower HERG expression [52]. Over-expression of HERG in low expressing cells resulted in an increase in sensitivity to drug treatment, again suggesting that potassium channels can be major players for the control and/or activation of apoptosis.…”
Section: Potassium Channels In Apoptosismentioning
“…Osteogenic Sarcoma ↑E2F-1 Transfection No change Sensitive [30] E2F-1(transcription factor) cyclin B1 levels and cdc2 kinase activity becoming sensitive to paclitaxel A549 Lung ↑HERG Transfection 0.875 0.039 [31] Potassium Channel, mechanism of paclitaxel sensitivity unknown SH-EP Neuroblastoma ↑MYCN Transfection 0.94 0.51 [32] Mechanism of paclitaxel sensitivity not studied [33] ↓BRCA1 leads to transcriptional modifications of the JNK pathway ↑JNK1 ↓JNK2 MCF-10A…”
Section: Genetic Modifications Which Induce the Inverse Cisplatin/pacmentioning