Hereditary Thrombophilia in the Era of COVID-19

Bădulescu, Oana Viola; Sîrbu, Paul Dan; Filip, Nina; Bordeianu, Gabriela; Cojocaru, Elena; Budacu, Cristian Constantin; Bădescu, Magda; Bararu-Bojan, Iris; Veliceasa, Bogdan; Ciocoiu, Manuela

doi:10.3390/healthcare10060993

Cited by 14 publications

(12 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the ROADMAP-CAD study is a prospective study that seeks to evaluate the utility of measuring hypercoagulability biomarkers to better diagnose severe coronary artery disease. This research by Gerotziafas et al showed promising results indicating that hypercoagulability assessment could be proposed to screen patients with severe CAD [76][77][78]-Table 3. • the anticardiolipin and anti-beta-2 glycoprotein-1 antibodies (IgG and IgM isotypes) and lupus anticoagulant;…”

Section: Discussionmentioning

confidence: 99%

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

Bararu Bojan,

Dobreanu,

Vladeanu

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Cardiovascular diseases, among which includes coronary artery disease, represent one of the most important causes of mortality and morbidity worldwide. Research aimed at determining the risk factors involved recognizes a group of “traditional” risk factors, but also more recent studies identified over 100 “novel” ones which may have a role in the disease. Among the latter is the thrombophilia profile of a patient, a pathology well-established for its involvement in venous thromboembolism, but with less studied implications in arterial thrombosis. This paper reviews the literature, explaining the pathophysiology of the thrombophilia causes associated most with coronary thrombosis events. Results of several studies on the subject, including a meta-analysis with over 60,000 subjects, determined the significant involvement of factor V Leiden, prothrombin G20210A mutation, plasminogen activator inhibitor–1 and antiphospholipid syndrome in the development of coronary artery disease. The mechanisms involved are currently at different stages of research, with some already established and used as therapeutic targets.

show abstract

Section: Discussionmentioning

confidence: 99%

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

Bararu Bojan,

Dobreanu,

Vladeanu

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Protein S deficiency is an inherited thrombophilia caused by reduced activity or impaired function of protein S, a glycoprotein with anticoagulant properties. Patients with protein S deficiency have a high risk of recurrence of venous thromboembolism (VTE), with an annual incidence of recurrence after the first event of 8.4% [ 1 ]. Thrombophilia can also be acquired, as it is in the setting of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Protein S Deficiency and COVID-19: A Brutal Combination Leading to Acute Submassive Bilateral Pulmonary Embolism

Chirumamilla¹,

Almerstani²,

Marcus³

et al. 2023

Cureus

View full text Add to dashboard Cite

Protein S deficiency is a form of inherited thrombophilia that occurs due to low levels of or improper function of protein S. The role of protein S is to inactivate procoagulant factors, and a deficiency results in an increased risk of thrombotic events. The coronavirus disease 2019 (COVID-19) infection has also been studied to increase the risk of venous thromboembolism (VTE) due to an interplay of several mechanisms. However, the risk of VTE in patients affected by both of these disease processes simultaneously has not been thoroughly studied, and so recommendations regarding routine screening and prophylaxis of VTE have also not been established. We discuss the case of a 46-year-old woman with a past history of protein S deficiency and a recent COVID-19 infection who presented with complaints of shortness of breath. Upon examination, she was found to be hypoxic and tachycardic. A computed tomography angiography of the chest was done and revealed acute submassive bilateral pulmonary embolism with right heart strain and pulmonary infarcts. She was initially treated with intravenous heparin and later transitioned to oral anticoagulation for a minimum of six months.

show abstract

“…Some authors demonstrated evidence that hereditary thrombophilia is a risk for severe COVID-19 and a marker of poor prognosis. Thus, testing for hereditary and congenital thrombophilia may benefit patients with early diagnosis and prevention of thromboembolism [ 69 , 70 ].…”

Section: Pregnancy Thrombophilia and Covid-19mentioning

confidence: 99%

Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

Sekulovski,

Mileva,

Chervenkov

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Pregnancy with SARS-CoV-2 infection can raise the risk of many complications, including severe COVID-19 and maternal–fetal adverse outcomes. Additionally, endothelial damage occurs as a result of direct SARS-CoV-2 infection, as well as immune system, cardiovascular, and thrombo-inflammatory reactions. In this narrative review, we focus on endothelial dysfunction (ED) in pregnancy, associated with obstetric complications, such as preeclampsia, fetal growth retardation, gestational diabetes, etc., and SARS-CoV-2 infection in pregnant women that can cause ED itself and overlap with other pregnancy complications. We also discuss some shared mechanisms of SARS-CoV-2 pathophysiology and ED.

show abstract

Hereditary Thrombophilia in the Era of COVID-19

Cited by 14 publications

References 106 publications

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease—What Is the Role of Thrombophilic Genes in the Development of This Pathology?

Protein S Deficiency and COVID-19: A Brutal Combination Leading to Acute Submassive Bilateral Pulmonary Embolism

Endothelial Dysfunction and Pregnant COVID-19 Patients with Thrombophilia: A Narrative Review

Contact Info

Product

Resources

About