Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease) An Electron Microscopic Study of the Vascular Lesions Before and After Therapy With Hormones

Diffuse Severe Digestive Angiodysplasia in Bernard-Soulier Syndrome

“…The authors of a prospective controlled trial (9) reported that oestro progestative therapy (OP) is effective in treating idiopathic angiodys plasia. OP might indeed enhance vWF synthesis and/or strengthen the integrity of the vascular wall, as suggested by ultrastructural studies (10). In our patient, vascular wall strengthening might be involved rather than vWF synthesis, since in any case BSS platelets lack the receptor for vWF factor.…”

Diffuse Antral Vascular Ectasia of the Stomach Effectively Treated by Estrogen‐progesterone Therapy

“…In addition, an obvious improvement of the gastric lesions could be confirmed endoscopically. Some investigators hypothesized the efficacy of hormone therapy to enable reduction of bleeding time, 8 improvement of mesenteric microcirculation, 9 and reconstruction of abnormal vessels 10 . Although the precise mechanism has not yet been fully clarified, our endoscopic observation suggests the efficacy of hormone therapy to be partly explained by reconstruction of abnormal microvessels.…”

Rendu-Osler-Weber Syndrome: case report and literature review

“…The histological findings once described by Jahnke in 1970 were an increase of submucosal vessels in intact endothelium, dilations of capillary, post-capillary and collector-type venules, with large elongated clusters of erythrocytes with fibrin channels in the connective tissue, red cells spread in the interstice around affected vessels, endothelial discontinuity and degeneration 2 , 5 , 10 . The first to describe these alterations was Menefee et al, in 1975, after a study with electron microscopy 10 .…”