Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

Kumar, Ashwani; Sharma, Vishavdeep; Singh, Vijay Pal; Kaundal, Madhu; Gupta, Maneesh K.; Bariwal, Jitender; Deshmukh, Rahul

doi:10.1016/j.mad.2015.05.009

Cited by 29 publications

(31 citation statements)

References 140 publications

(114 reference statements)

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“…29 Although the currently prescribed molecules provide some improvement in the clinical condition of patients, it is at a cost of having to bear the burden of their adverse effects and lack of their curative effects. 37 Thus it is imperative to keep exploring different approaches that can be used to target the AD complications which could be translated into successful clinical trials. The herbs have been used as medicines from ancient times, as they are safer and have no side effects.…”

Section: Discussionmentioning

confidence: 99%

Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Rimpi

Deshmukh

2020

IJPI

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Background: With the constant failure of the clinical trials and continuous exploration of a therapeutic target against Alzheimer's disease (AD) is the utmost needed. Chebulinic acid (ChA) has been reported to possess neuroprotective potential in various neurodegenerative models such as anxiety and depression. Materials and Methods: In the current study, the ChA was challenged on the progression of AD induced by intracerebroventricular (ICV)-streptozotocin (STZ)-induced neurotoxicity to determine its therapeutic potential in experimental dementia. STZ was infused bilaterally (3 mg/kg/icv) on day 1 st and 3 rd after surgery. ChA (25, 50 and 100 mg/kg/p.o) was administered from 7 th day onwards up to 21 st day following 1 st ICV-STZ infusion. Cognitive impairment was evaluated by actophotometer, Morris water maze (MWM) and object recognition task (ORT) in rats whereas biochemical, neurochemical, neuroinflammatory were evaluated using hipoocampal brain regions on day 22 nd. Results: Ventricular administration of STZ in rats found to significantly shorten the latency time on the MWM and ORT which was associated with significant alterations in hippocampal biochemistry, including elevation in oxidative stress and compromised antioxidant defense, neurotransmitter alteration and elevation in neuroinflammatory cytokine levels. ChA treatment significantly prevented the ICV-STZ-induced memory deficit by attenuating the hippocampal neuronal loss, neuroinflammation and compromised antioxidant defense and cholinergic deficits in rats. Conclusion: These results clearly pointed to the pivotal role of ChA in ICV-STZ induced neurotoxicity and its association may be a promising alternative to be investigated in the treatment of AD-like dementia.

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Section: Discussionmentioning

confidence: 99%

Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Rimpi

Deshmukh

2020

IJPI

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“…Bcl-2 and Bax proteins are a pair of antagonistic proteins, apoptosis is accelerated by redundant Bax while apoptosis is inhibited by excessive Bcl-2 protein [40]. Osthole may also take a counter-AD effect by inhibiting cyclic nucleotide phosphodiesterases (PDEs) which are responsible for the degradation of cAMP and cGMP [41]. Furthermore, the PDE4 and PDE5 inhibition was the key to an anti-neurotoxicity effect caused by Aβ25-35 with Osthole at 40 mg/kg [42].…”

Section: Nervous System and Mental Illness Memory Loss And Neuron Degmentioning

confidence: 99%

Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson

Sun

Yang

Lenon

2020

IJMS

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Cnidium monnieri (L.) Cusson (CMC) is a traditional Chinese herbal medicine that has been widely grown and used in Asia. It is also known as “She chuang zi” in China (Chinese: 蛇床子), “Jashoshi” in Japan, “Sasangia” in Korea, and “Xa sang tu” in Vietnam. This study aimed to provide an up-to-date review of its phytochemistry, ethnopharmacology, pharmacokinetics, and toxicology. All available information on CMC was collected from the Encyclopedia of Traditional Chinese Medicines, PubMed, EMBASE, ScienceDirect, Scopus, Web of Science, and China Network Knowledge Infrastructure. The updated chemical structures of the compounds are those ones without chemical ID numbers or references from the previous review. A total of 429 chemical constituents have been elucidated and 56 chemical structures have been firstly identified in CMC with traceable evidence. They can be categorized as coumarins, volatile constituents, liposoluble compounds, chromones, monoterpenoid glucosides, terpenoids, glycosides, glucides, and other compounds. CMC has demonstrated impressive potential for the management of various diseases in extensive preclinical research. Since most of the studies are overly concentrated on osthole, more research is needed to investigate other chemical constituents.

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“…Consequently, cognitive performance increases. [5][6][7][8][9][10] These second messengers are required for the expression of brain-derived neurotrophic factor (BDNF) via the protein kinase A/G (PKA/G)-cAMP response element binding (CREB) signaling pathway. BDNF is an important protein for the proliferation, differentiation, and plasticity of synapses in the regulation and maintenance of cognitive function, especially learning and memory.…”

Section: Introductionmentioning

confidence: 99%

“…PDE1 inhibitors may be obtained from medicinal plants because they have been considered a basis for discovering bioactive molecules. 6,10,21 Secang (Caesalpinia sappan L.; CS) is an Indonesian medicinal plant widely used as a natural red pigment in several herbal medicines. It is also the main ingredient of "Wedang Uwuh, " a traditional drink composed of CS wood, clove leaf, and ginger, and it is commonly consumed as a stamina enhancer, body warmer, and refreshment drink.…”

Section: Introductionmentioning

confidence: 99%

Caesalpinia sappan L. Wood is a Potential Source of Natural Phosphodiesterase-1 Inhibitors

2020

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Introduction: A decrease in cAMP and cGMP levels in the brain is linked to human cognitive problems. The degradation of cellular cAMP and cGMP is attributed to phosphodiesterases (PDEs), which constitute a superfamily of enzymes. The inhibition of PDE1 is a promising mechanism to increase cAMP and cGMP levels associated with cognitive disorders. Caesalpinia sappan L. (CS) wood is a natural coloring agent usually consumed as a traditional refreshment or drink by people in Yogyakarta, Indonesia. However, scientific evidence regarding the inhibitory activity of CS wood against PDE1 has yet to be obtained. This study aimed to investigate the potency of CS wood as a PDE1 inhibitor. Methods: The ethanol extract of CS wood and its fractions were evaluated in vitro by using a cyclic nucleotide phosphodiesterase assay kit. The presence of brazilin in the extract and fractions was analyzed by thin-layer chromatography. In silico assay was performed using MOE software to obtain insights into the interaction between compounds in the CS wood and the enzyme. Results: Ethanol extract and ethyl acetate soluble fraction effectively inhibited the PDE1 activity. Interestingly, brazilin, the major compound in CS wood, also exhibited a potent inhibitory effect on the enzyme. The in silico assay revealed that the interaction between tetraacetylbrazilin and brazilin with the PDE1B active site involved hydrogen bonding and π-π interactions. Conclusion: Ethanol extract, ethyl acetate soluble fraction, and brazilin inhibited the PDE1 activity. CS wood and its chemical constituent could be developed as natural cognitive enhancers.

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Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

Cited by 29 publications

References 140 publications

Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson

Caesalpinia sappan L. Wood is a Potential Source of Natural Phosphodiesterase-1 Inhibitors

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