Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation

Fu, Yan; Jin, Yang; Wang, Xingyu; Yang, Ping; Zhao, Yang; Li, Kun; Chen, Yongjun; Xu, Ying

doi:10.1155/2018/9348046

Cited by 23 publications

(11 citation statements)

References 71 publications

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“…Microglia are the resident macrophage cells in the central nervous system and host defense mechanisms producing pro-inflammatory cytokines and ROS (Lee et al, 2018). When activated during brain injuries or by invading pathogens, they produce pro-inflammatory cytokines such as IL-1β, IL-16, TNFα, and TGF-β1 (Fu et al, 2018). Studies reveal that terpenes and terpenoids are involved in suppressing microglia-mediated inflammation involved in acute or chronic neurodegenerative diseases (Sundaram and Gowtham, 2012;Ong et al, 2015;Quintans et al, 2019).…”

Section: Neuroinflammationmentioning

confidence: 99%

Therapeutic Applications of Terpenes on Inflammatory Diseases

et al. 2021

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In the last decades, the search for natural products with biological applications as alternative treatments for several inflammatory diseases has increased. In this respect, terpenes are a family of organic compounds obtained mainly from plants and trees, such as tea, cannabis, thyme, and citrus fruits like lemon or mandarin. These molecules present attractive biological properties such as analgesic and anticonvulsant activities. Furthermore, several studies have demonstrated that certain terpenes could reduce inflammation symptoms by decreasing the release of pro-inflammatory cytokines for example, the nuclear transcription factor-kappa B, interleukin 1, and the tumor necrosis factor-alpha. Thus, due to various anti-inflammatory drugs provoking side effects, the search and analysis of novel therapeutics treatments are attractive. In this review, the analysis of terpenes’ chemical structure and their mechanisms in anti-inflammatory functions are addressed. Additionally, we present a general analysis of recent investigations about their applications as an alternative treatment for inflammatory diseases. Furthermore, we focus on terpenes-based nanoformulations and employed dosages to offer a global perspective of the state-of-the-art.

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Section: Neuroinflammationmentioning

confidence: 99%

Therapeutic Applications of Terpenes on Inflammatory Diseases

et al. 2021

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“…In citrus fruits such as Citrus paradise and Citrus sinensis, Narngenin is a strong flavonoid found to be abundant. It has strong antioxidant, anti-inflammatory and neuroprotective properties [ 5 , 43 ]. The study shows that narngenin has prevented neurotoxicity caused by 6-hydroxydopamine (6-OHDA) by triggering the Nrf2-ARE signaling pathway.…”

Section: Natural Substances Induced Nrf2 Activation In Neurodegeneratmentioning

confidence: 99%

Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review

Singh

Nagalakshmi

Sharma

et al. 2021

Heliyon

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The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) play a crucial role in cellular redox and metabolic system. Activation of Nrf2 may be an effective therapeutic approach for neuroinflammatory disorders, through activation of antioxidant defences system, lower the inflammation, line up the mitochondrial function, and balancing of protein homeostasis. Various recent studies revealed that many of active substance obtained from plants have been found to activate the Nrf2 and to exert neuroprotective effects in various experimental models, raising the possibility that activation of Nrf2 may be an effective therapeutic approaches for neuroinflammatory disorders. The objective of this review was to evaluate the neuroprotective property of natural substance against neuroinflammatory disorders by reviewing the studies done till today. The outcomes of various in vitro and in vivo examinations have shown that natural compounds producing neuroprotective effects in neuronal system via activation of Nrf2. Herein, we also reviewed the studies to understand the role of Nrf2 for curing CNS disorders. Here we can conclude, herbal/natural moieties having potency to fight and prevent from neuroinflammatory disorders due to their abilities to activate Nrf2 pathway.

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“…They closely monitor the changes in the microenvironment around the brain and react quickly to maintain the balance of the brain microenvironment. However, although the activation of microglia plays a central role in the maintenance of normal physiological function of the brain, excessive activation can also induce a variety of neurotoxic effects [74, 75]. Previous studies on microglia centered on their function as mediators of injury, inflammation, and neurodegeneration [76-78].…”

Section: The Relation Between α-Syn and Neuroinflammation In Pdmentioning

confidence: 99%

Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson’s Disease

Zhong²,

Liu³

et al. 2020

Neurodegener Dis

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Background: Parkinson’s disease (PD) is a multifactorial, chronic, and progressive neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of Lewy bodies, plays an important role in the pathological hallmarks of PD. However, the pathological function of α-syn and the molecular mechanisms responsible for the degeneration of dopaminergic neurons are still elusive. Summary: Cumulative evidence implicates that abnormal processing of α-syn will be predicted to lead to pathological changes in PD. Key Messages: In this review, we summarize the structure and physiological function of α-syn, and further discuss the interplay of pathology, neuroinflammation, and environmental factors in PD. Additionally, we suggest future directions for understanding the toxicity of α-syn to neurons, which may ultimately encourage us to better design disease-modifying therapeutic strategies for PD.

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Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation

Cited by 23 publications

References 71 publications

Therapeutic Applications of Terpenes on Inflammatory Diseases

Therapeutic Applications of Terpenes on Inflammatory Diseases

Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review

Alpha-Synuclein: The Interplay of Pathology, Neuroinflammation, and Environmental Factors in Parkinson’s Disease

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