Hepcidin response to three consecutive days of endurance training in hypoxia

Sumi, Daichi; Hayashi, Nanako; Yamaguchi, Keiichi; Badenhorst, Claire E.; Goto, Kazushige

doi:10.1007/s00421-021-04599-3

Cited by 1 publication

(1 citation statement)

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“…Given hepcidin's crucial role in controlling iron uptake kinetics after exercise, research has sought to clarify how lifestyle factors (e.g., dietary intake/patterns) (Badenhorst et al, 2015a , b , 2016 ; McKay et al, 2019 , 2020 ) and external environments (e.g., altitude and heat) (Badenhorst et al, 2014 ; Govus et al, 2017 ; Hayashi et al, 2020 ; McKay et al, 2021 ; Sumi et al, 2021 ) influence hepcidin kinetics in active individuals. Research has also investigated the changes in hepcidin kinetics in response to exercise training, the timing of iron-rich foods and oral iron supplements which has provided translatable research outcomes detailing when iron could be ingested by active individuals to enhance its uptake (Moretti et al, 2015 ; Stoffel et al, 2017 ; McCormick et al, 2019 , 2020 ).…”

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confidence: 99%

A contemporary understanding of iron metabolism in active premenopausal females

Badenhorst

Forsyth

Govus

2022

Front. Sports Act. Living

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Iron metabolism research in the past decade has identified menstrual blood loss as a key contributor to the prevalence of iron deficiency in premenopausal females. The reproductive hormones estrogen and progesterone influence iron regulation and contribute to variations in iron parameters throughout the menstrual cycle. Despite the high prevalence of iron deficiency in premenopausal females, scant research has investigated female-specific causes and treatments for iron deficiency. In this review, we provide a comprehensive discussion of factors that influence iron status in active premenopausal females, with a focus on the menstrual cycle. We also outline several practical guidelines for monitoring, diagnosing, and treating iron deficiency in premenopausal females. Finally, we highlight several areas for further research to enhance the understanding of iron metabolism in this at-risk population.

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