Hepcidin and iron metabolism: From laboratory to clinical implications

Evaluation of hepcidin as a biomarker for the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease

“…Recently, several studies have been conducted to evaluate the role of hepcidin in various diseases and its diagnostic reliability in distinguishing IDA from ACD. 3,5,[9][10][11][12][13][14] The first successful validation of a competitive enzyme-linked immunosorbent assay (c-ELISA) for detecting physiological and pathological changes in serum and urine hepcidin was conducted by Ganz et al 15 Hepcidin measurement could be helpful in distinguishing ACD from IDA, as hepcidin production differs in these forms anaemia.…”

Association of iron metabolic enzyme hepcidin expression levels with the prognosis of patients with pancreatic cancer

“…Iron is incorporated into the enzymes and proteins required for important cellular processes, such as oxygen transport, proliferation and energy production (5). Iron absorption in the duodenum and upper jejunum is highly regulated to maintain iron levels in the body (6). However, iron works as a double-edged sword; iron overload is a risk factor for cancer, presumably through the generation of reactive oxygen species (ROS).…”

Iron deficiency and risk of early readmission following a hospitalization for acute heart failure

“…As Pasricha et al 2 and the possible presence of chronic kidney disease, a diagnosis of ID solely based on serum ferritin and TSAT may underestimate the prevalence of functional ID. As discussed by Franchini et al 6 and Beerenhout et al, 7 other parameters such as soluble transferrin receptor (sTfR) are not influenced by inflammation, and we therefore strongly suggest considering this parameter or low circulating hepcidin in diagnosing ID in AHF. Conflict of interest: none declared.…”