Hepatotoxicity due to herbal dietary supplements: Past, present and the future

Gurley, Bill J.; McGill, Mitchell R.; Koturbash, Igor

doi:10.1016/j.fct.2022.113445

Cited by 23 publications

(23 citation statements)

References 171 publications

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“…Of note, some recent human case studies reported that new pharmaceutical formulations which enhance the bioavailability of curcuminoids 14 were associated with hepatotoxicity or autoimmune hepatitis 15,16 . Similar findings have been reported for other plant bioactives, especially when their bioavailability has been increased by pharmacological means 17,18 . Secondary plant compounds are usually recognized by the body as xenobiotics and, hence, induce the Nrf2‐dependent detoxification pathway.…”

Section: Introductionsupporting

confidence: 52%

“…15,16 Similar findings have been reported for other plant bioactives, especially when their bioavailability has been increased by pharmacological means. 17,18 Secondary plant compounds are usually recognized by the body as xenobiotics and, hence, induce the Nrf2-dependent detoxification pathway. Accordingly, one can assume that too high an intake of these compounds can no longer be processed by the liver.…”

Section: Introductionmentioning

confidence: 99%

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Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster

Lüersen,

Jöckel,

Chin

et al. 2023

BioFactors

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Recent reports indicated that the phytochemical curcumin possesses iron‐chelating activity. Here, by employing the fruit fly Drosophila melanogaster, we conducted feeding studies supplementing curcumin or, as a control, the iron chelator bathophenanthroline (BPA). First, the absorption and further metabolization of dietary curcuminoids were proved by metabolomics analyses. Next, we found that 0.2% dietary curcumin, similar to BPA, lowered the iron but also the cobalt content, and to a lesser extent affected the manganese and zinc status. Supplementation during larval stages was required and sufficient for both compounds to elicit these alterations in adult animals. However, curcumin‐induced retarded larval development was not attributable to the changed trace metal status. In addition, a reduction in the iron content of up to 70% by curcumin or BPA supplementation did not reduce heme‐dependent catalase activity and tolerance toward H2O2 in D. melanogaster. Moreover, polyamines were not influenced by curcumin treatment and decreased iron levels. This was confirmed for selected organs from 0.2% curcumin‐treated mice, except for the spleen. Here, elevated spermidine level and concomitant upregulation of genes involved in polyamine production were associated with a putatively anemia‐derived increased spleen mass. Our data underline that the metal‐chelating property of curcumin needs to be considered in feeding studies.

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Section: Introductionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster

Lüersen,

Jöckel,

Chin

et al. 2023

BioFactors

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“…Consequently, case reports and other such scholarly projects have been crucial in identifying DILI caused by HDS. 10 DILI has been shown to be associated with oxidative stress leading to hepatocyte inflammation and eventual necrosis.…”

Section: Discussionmentioning

confidence: 99%

Unexpected Drug-Induced Liver Injury Associated With MenoFit: A Synbiotic Menopause Supplement

Dadlani,

Anudu,

Marginean

2023

ACG Case Rep J

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MenoFit is a widely available over-the-counter synbiotic supplement, which is marketed for use in relieving menopausal symptoms. So far, there is no published data on liver injury because of its use. We present the first reported case of MenoFit-induced liver injury in a patient who presented with 1 week of jaundice and abnormal liver biochemical tests in the absence of other risk factors and negative comprehensive workup for known etiologies of liver disease.

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“…Such a supplement contains one or more dietary ingredients (including vitamins, minerals, herbs or other botanicals, amino acids, and other substances), is intended to be taken by mouth, and is labeled on the front panel as being a dietary supplement [ 2 ]. This broad definition encompassed more than 80,000 products available for sale in the United States in 2018 [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dietary supplements of botanical or herbal origin account for nearly 30% of all dietary supplements on the market, whether they contain extracts from a single plant or from multiple plant sources [ 3 ]. The botanical dietary supplement industry in the United States is expanding rapidly.…”

Section: Introductionmentioning

confidence: 99%

Everyday Evaluation of Herb/Dietary Supplement–Drug Interaction: A Pilot Study

et al. 2023

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A lack of reliable information hinders the clinician evaluation of suspected herb–drug interactions. This pilot study was a survey-based study conceived as a descriptive analysis of real-life experiences with herb–drug interaction from the perspective of herbalists, licensed health-care providers, and lay persons. Reported dietary supplement–drug interactions were evaluated against the resources most commonly cited for the evaluation of potential supplement–drug interactions. Disproportionality analyses were performed using tools available to most clinicians using data from the U.S. Federal Adverse Event Reporting System (FAERS) and the US Center for Food Safety and Applied Nutrition (CFSAN) Adverse Event Reporting System (CAERS). Secondary aims of the study included exploration of the reasons for respondent use of dietary supplements and qualitative analysis of respondent’s perceptions of dietary supplement–drug interaction. While agreement among reported supplement–drug interactions with commonly cited resources for supplement–drug interaction evaluation and via disproportionality analyses through FAERS was low, agreement using data from CAERS was high.

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Hepatotoxicity due to herbal dietary supplements: Past, present and the future

Cited by 23 publications

References 171 publications

Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster

Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of D. melanogaster

Unexpected Drug-Induced Liver Injury Associated With MenoFit: A Synbiotic Menopause Supplement

Everyday Evaluation of Herb/Dietary Supplement–Drug Interaction: A Pilot Study

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