Hépatotoxicité par Chenopodium ambrosioides à propos de 3 observations (colligées à l’hôpital militaire d’instruction Mohammed V, Rabat – Maroc)

Derraji, Soufiane; Mahassin, F.; Rhalem, Naïma; Ouzzif, Z.

doi:10.1016/j.toxac.2014.05.001

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…-Congestion of the lungs, metaplastic changes in the mucosal surface of the stomach, and necrosis of the kidney tubules (Amole and Izegbu, 2005); -Liver toxicity (Derraji et al, 2014);…”

Section: Scientific Name Vernacular Name Toxic Principles Symptoms Of...mentioning

confidence: 99%

Phytotherapy in response to COVID-19 and risks of intoxication: A field study in the city of Meknes (Morocco)

Najem¹,

Ibijbijen²,

Nassiri³

2022

J Pharm Pharmacogn Res

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Context: The contagious global pandemic of coronavirus 2019 (COVID-19) has prompted many Moroccans to turn to traditional phytoremedies. Aims: To highlight the ethnopharmacological information and the risks of intoxication related to the use of herbal medicine to combat COVID-19. Methods: Through a semi-structured questionnaire and using the “Free listing” technique, an ethnobotanical survey was conducted among 36 herbalists of the Meknes prefecture to collect ethnopharmacological data on species used in the fight against COVID-19. Then, many databases were used to document their pharmacological and toxicological activities. Results: A total of 36 species in 22 families were reported to be used to prepare traditional recipes against COVID-19. According to the relative frequency index of citation, the species Artemisia herba-alba Asso, Eucalyptus globulus Labill, Syzygium aromaticum (L.) Merr. & L.M. Perry, Citrus limon (L.) Osbeck, and Zingiber officinale Roscoe. were recommended by all respondents and recorded the highest usage values. Based on the value of the plant parts index, leaves were the most used part (PPV = 0.37). Most of the remedies were prepared as infusions and administered orally. The bibliographic research revealed that the plants used have several biological activities and are frequently used to treat respiratory diseases. However, some of them have been reported to be toxic. Conclusions: Recommended species are endowed with innumerable biological activities. They can be a promising alternative to combat COVID-19. However, their toxic effects require pharmacotoxicological studies to ensure the safety and efficacy of these natural remedies.

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“…-Congestion of the lungs, metaplastic changes in the mucosal surface of the stomach, and necrosis of the kidney tubules (Amole and Izegbu, 2005); -Liver toxicity (Derraji et al, 2014);…”

Section: Scientific Name Vernacular Name Toxic Principles Symptoms Of...mentioning

confidence: 99%

Phytotherapy in response to COVID-19 and risks of intoxication: A field study in the city of Meknes (Morocco)

Najem¹,

Ibijbijen²,

Nassiri³

2022

J Pharm Pharmacogn Res

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“…Chenopodium ambrosioides L. has long been used in traditional medicine, as it is highly recommended by herbalists as an antiseptic, analgesic, antipyretic, antispasmodic, anti-inflammatory, galactogenic, or for its healing effect in oral aphthosis and skin wounds. All parts of the plant (root, leaves, flowers, seeds), whether fresh or dried, are used [5].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported cases of liver toxicity following anserine consumption. Cases of hepatic cytolysis and cholestasis have been described in all studies [5,7].…”

Section: Discussionmentioning

confidence: 99%

A Fatal Case Report of Chenopodium ambrosioides L. (M’khinza) Intoxication

Elhaddadi,

Hamami,

Elouali

et al. 2024

Cureus

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Chenopodium ambrosioides L. is a plant belonging to the Chenopodiaceae family, known for its use in traditional medicine as a remedy for its antiseptic, analgesic, antipyretic, antispasmodic, and antiinflammatory properties. It is used for its therapeutic properties internally as an infusion or externally as a vermifuge. Its use can be responsible for serious, even fatal, side effects and intoxications, particularly in infants and children. These may include neurological, digestive, hepatic, or renal complications. We present a case of Chenopodium ambrosioides L. intoxication in a four-year-old girl, resulting from repeated highdose infusions of this plant for antipyretic purposes. She was admitted to the pediatric emergency department for management of a disorder of consciousness four hours after ingesting Chenopodium ambrosioides L. to treat acute fever.

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“…Several species, including D. botrys , and D. ambrosioides possess compounds that have been demonstrated to interfere with mitochondrial function ( Nagle et al, 2011 ). The toxicity of EO obtained from Dysphania can be associated with the presence of some major components, carvacrol (19) , caryophyllene oxide (35) , and ascaridole (29) , which induce suppression of the respiratory function in the mitochondria, or in the complex I of the mitochondrial electron transport chains ( Figure 5 ) ( Monzote et al, 2018 ), this toxic effect emerging on the kidneys, liver, and intestine ( Derraji et al, 2014 ). Nevertheless, in a recent study by Li et al, 2020 ( Li et al, 2020 ), dose-dependent toxicity was demonstrated in mice, providing some support for using the EO in a safe way in traditional medicine.…”

Section: Toxicologymentioning

confidence: 99%

Essential oils from Dysphania genus: Traditional uses, chemical composition, toxicology, and health benefits

Dagni

Hegheș²,

Suharoschi³

et al. 2022

Front. Pharmacol.

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The genus Dysphania belongs to the Amaranthaceae family and is known for its many health benefits. Therefore, it is commonly available worldwide and includes more than 47 species, five species have been mainly reported, and D. ambrosioides has been one of the most widely used plants for thousands of years as a remedy for a wide range of ailments. In recent investigations, the essential oils of the genus Dysphania have been examined for their antibacterial, antioxidant, and antiviral properties related to specific components such as terpenoid compounds that exhibit pharmacological activity. Moreover, some of Dysphania’s compounds show a toxicological effect. Therefore, the objective of the study was to provide EO chemical composition and pharmacological data of the genus Dysphania.

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Hépatotoxicité par Chenopodium ambrosioides à propos de 3 observations (colligées à l’hôpital militaire d’instruction Mohammed V, Rabat – Maroc)

Cited by 6 publications

References 11 publications

Phytotherapy in response to COVID-19 and risks of intoxication: A field study in the city of Meknes (Morocco)

Phytotherapy in response to COVID-19 and risks of intoxication: A field study in the city of Meknes (Morocco)

A Fatal Case Report of Chenopodium ambrosioides L. (M’khinza) Intoxication

Essential oils from Dysphania genus: Traditional uses, chemical composition, toxicology, and health benefits

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