Hepatoprotective effects of Huangqi decoction (Astragali Radix and Glycyrrhizae Radix et Rhizoma) on cholestatic liver injury in mice: Involvement of alleviating intestinal microbiota dysbiosis

Zou, Juan; Li, Wenkai; Wang, Guofeng; Fang, Su; Cai, Jingyi; Wang, Tianming; Zhang, Hua; Liu, Ping; Wu, Jiasheng; Ma, Yueming

doi:10.1016/j.jep.2020.113544

Cited by 31 publications

(18 citation statements)

References 26 publications

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“…At the genus level, the flora of 13 genera increased significantly after APAP treatment, and the 7 genera recovered to varying degrees after BPP treatment, including norank_f_norank_o_ Clostridia_UCG-014, Erysipelatoclostridium, Gordonibacter, norank_f_Eubacterium_coprostanoli genes_group, Eubacterium_nodatum_group, Family_XIII_AD3011_group, and Eubacterium_ brachy_group. These bacteria are closely related to liver injury or metabolism [47][48][49][50][51]. Furthermore, BPP increased the richness of Corynebacterium, Prevotellaceae_UCG-001, Alloprevotella, and Jeotgalicoccus, which was similar to the report that walnut green peel polysaccharide and Spirulina platensis polysaccharides have a hepatoprotective effect [11,52].…”

Section: Discussionsupporting

confidence: 83%

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Hao

Chen

et al. 2022

Nutrients

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Liver injury caused by an overdose of acetaminophen (APAP) is a major public health problem. This study aimed to evaluate the effects of Broussonetia papyrifera polysaccharide (BPP) on liver injury and intestinal flora induced by APAP. The results showed that BPP could protect against APAP-induced liver injury, alleviate liver apoptosis, improve antioxidant capacity and enhance the liver’s detoxification ability to APAP. At the same time, BPP improved the intestinal flora disorder caused by APAP. More importantly, we found that the hepatoprotective effect of BPP disappeared after the depletion of gut microbiota in mice. Further, we reconstructed the intestinal flora structure of mice through fecal microbiota transplantation and found that the symptoms of APAP—induced liver injury were effectively alleviated. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury and might be mediated by intestinal flora.

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Section: Discussionsupporting

confidence: 83%

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Hao

Chen

et al. 2022

Nutrients

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“… 107 Huangqi decoction (Astragali Radix and Glycyrrhizae Radix et Rhizoma), a classic Chinese herbal formula, ameliorates 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver injury, and alleviates the increased hepatic expression of pro-inflammatory factors and NLRP3 inflammasome activation. 108 …”

Section: Pharmacological Inhibitors Of Nlrp3 Inflammasome In Glycyrrhizamentioning

confidence: 99%

NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Wang¹,

Xu²,

Li³

et al. 2022

JIR

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Inflammation is the tissues’ defense response after the body is stimulated by microbial infection or damage signals, and it is initiated when pattern recognition receptors recognize pathogen-related molecular patterns and danger-related molecular patterns. The hyperactivation of NLRP3 inflammasome, the main driving force of immune outbreaks, is involved in a wide range of inflammatory diseases. Meanwhile, growing evidence has indicated that the development of NLRP3-targeted therapies offers great potential and promise for the treatment of related diseases. The search for and development of efficacious anti-inflammatory prodrugs from natural sources of plants and traditional Chinese medicines (TCMs) have received extensive attention. Glycyrrhiza , an important minister in the kingdom of TCMs, has high activity and a wide range of therapeutic effects. Studies have shown that a variety of active components found in Glycyrrhiza , such as licochalcone A, echinatin, isoliquiritigenin, and glycyrrhizin, produce a wide range of anti-inflammatory effects by discouraging NLRP3 inflammasome activation. Here, we summarize the role and mechanism of the active ingredients in Glycyrrhiza that target the NLRP3 inflammasome and treat related inflammatory diseases. We describe a favorable approach for the development of natural, safe, and efficient drugs that exploit these naturally occurring active ingredients to treat NLRP3-driven diseases.

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“…The source plants are mainly distributed in Shanxi, Inner Mongolia and Gansu in China (Fu et al, 2014). AR has immune‐enhancing (Wang et al, 2012), anti‐tumor (Li, He, et al, 2020; Li, Sun, et al, 2020), anti‐inflammatory (Ying et al, 2021), hepatoprotective (Zou et al, 2021), antioxidant (Wang, Ding, et al, 2021), antiviral (Liang et al, 2019) and other effects, and is widely used in drugs, cosmetics, food, health products and beverages (Napolitano et al, 2013). AR appears most frequently in herbal prescriptions for the prevention of New Coronary Pneumonia (COVID‐19) and has received a lot of attention from scholars (Chinsembu, 2020).…”

Section: Introductionmentioning

confidence: 99%

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

Guo

Sha

et al. 2022

Biomedical Chromatography

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Nowadays, cultivated variants and adulterants of Astragali Radix (AR) have flooded the market, causing the quality assurance of AR to be challenging. To address this issue, we combined network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of AR. Specifically, through network pharmacology, a complete understanding of the active components and pharmacological activities of AR was established. In addition, establishing fingerprint profiles and multicomponent quantitation by high-performance liquid chromatography (HPLC) is convenient and comprehensive, and can more fully reflect the overall situation of the distribution of various chemical components. To evaluate and differentiate AR from different origins, hierarchical cluster analysis and principal component analysis were performed. The result showed that AR acts synergistically through multiple targets and pathways. The content of chemical components in AR from different origins varied significantly. Combining network pharmacology and multicomponent quantification results, astragaloside II and IV and formononetin can be used as quality markers for the quality control of AR. This study provides a comprehensive and reliable strategy for the quality evaluation of AR and identifies its quality markers to ensure the quality of the herb.

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Hepatoprotective effects of Huangqi decoction (Astragali Radix and Glycyrrhizae Radix et Rhizoma) on cholestatic liver injury in mice: Involvement of alleviating intestinal microbiota dysbiosis

Cited by 31 publications

References 26 publications

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

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