Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats

Kim, Yong-Jae; You, Yanghee; Yoon, Ho‐Geun; Lee, Yoo‐Hyun; Kim, Kyungmi; Lee, Jeongmin; Kim, Min Soo; Kim, Jong-Choon; Jun, Woojin

doi:10.1016/j.foodchem.2013.11.058

Cited by 70 publications

(46 citation statements)

References 32 publications

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“…They reported that at least 235 compounds, primary phenolic compounds and terpenoids have been identified from the species, including 22 diarylheptanoids and diarylpentanoids, 6 monomeric phenylpropene and 2 other phenolic compounds, 68 monoterpenes, 105 sesquiterpenes, 4 diterpenes, 3 triterpenoids, 4 steroids, 5 fatty acids, and 16 other compounds. Adaramoye et al, 2010;Baxla et al, 2013;Kim et al, 2012;Kim et al, 2014;Salama et al, 2013;Sengupta et al, 2011;Varalakshmi and Abhinov, 2015 (Unnikrishnan and Nishteswar, 2015). Even turmeric is traditionally applied on fresh cuts to stop bleeding by the rural and tribal population of India (Shivalingu et al, 2015), but there is no report explaining the possible involvement of turmeric in stopping the bleeding.…”

Section: Phytochemical Substancesmentioning

confidence: 99%

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Sirisidthi

Kosai

Jiraungkoorskul

et al. 2016

IJARe

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The venous and arterial thromboembolic disorders are still be the major cause of morbidity and mortality worldwide. Now a days, the concept of "healthy diets" is very popular in the present lifestyle. So, the use of antithrombotic agents is of considerable interest in the role of natural food products and their bioactive components in the prevention and treatment of these disorders. Moreover, epidemiologic studies have provided evidence that foods with the thrombolytic/fibrinolytic effect could reduce the risk of thrombosis. "Blood thinner foods" have the antiplatelet, anticoagulant, and/or fibrinolytic properties. Natural foods that contain salicylates can mimic some of the antiplatelet effects of cardiovascular drug like aspirin. Fruits (i.e., grapefruit, guava, kiwi, pineapple, and watermelon), vegetables (i.e., alfalfa, beans, corn, potato, radish, and zucchini), and spices (i.e., chili, curry, ginger, rosemary and turmeric) are reported that they are containing salicylates compounds. Turmeric (Curcuma longa) is a small rhizomatous perennial herb belonging to Zingiberaceae family originating from Southeastern Asia. It is a folk remedy for applying on fresh cuts to stop bleeding and for the healing of wound. Further, turmeric has been shown to possess anticancer, antidiabetic, antifertility, anti-inflammatory, antimicrobial and antioxidant properties. Its phytochemical substances are alkaloids, curcuminoids, flavonoids, glycosides, saponins, which all of these contribute to its remedial properties. This article provides a brief overview of the antithrombotic activity of turmeric, C. longa to further provide an up-to-date review showing its importance.

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Section: Phytochemical Substancesmentioning

confidence: 99%

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Sirisidthi

Kosai

Jiraungkoorskul

et al. 2016

IJARe

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“…[13] In chronic liver disorders (alcoholic and nonalcoholic fatty liver diseases and drug-induced liver injury caused by the imbalanced defense mechanism of antioxidants and overproduction or incorporation of free radicals), biological molecules and key cellular component in the liver are damaged by ROS production.The antioxidant medicines may have beneficial effect, but for the long-term use, they are associated with serious complication. [27] In the study done on 18 healthy men for 75 days, it was found that the hydroalcoholic extract of curcumin longa are mainly responsible for decreasing in concentration of serum lipid peroxide. [25] Studies revealed that fermented Curcuma longa L. (FC) has the hepatoprotective effect.…”

Section: Anti-oxidant Effectsmentioning

confidence: 99%

“…FC improves the impaired antioxidant status in the rat liver, as indicated by decreasing oxidative stress via preventing lipid preoxidation and improving hepatic antioxidant status. [27] If the liver is damaged, the livers enzymes ATL and AST will increase in the blood, signaling liver disease. Thus, the reduction of ALT and AST levels cause improvement in hepatic function.…”

Section: Anti-oxidant Effectsmentioning

confidence: 99%

Turmeric (<i>Curcuma longa</i>): From a Variety of Traditional Medicinal Applications to its Novel Roles as Active Antioxidant, Anti-Inflammatory, Anti-Cancer and Anti-Diabetes

Hamidpour

et al. 2015

IJPPE

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ABSTRACT.Curcumin longa, which is commonly known as Turmeric, is an herbaceous perennial plant from the Curcuma genus that prospers in mainly Eastern Asia. Through a series of forms including powder and extract, the plant has been traditionally used to assist in inflammation and wound healing. Turmeric has been shown to alleviate the pain of inflammation in diseases such as rheumatoid arthritis and psoriasis, overall promoting the immune system response of acute inflammation for its therapeutic abilities and alleviating chronic inflammation. Not only has it been shown to assist in inflammation, but Turmeric has been shown to assist in preventing and battling cancer through its cytotoxic activities while boosting apoptosis to control the growth and distribution of cells. Along with these abilities, this plant assists with the pain and inflammation involved with diabetes. Turmeric is able to do this because of it being largely composed of a substance called Curcumin, a mixture of Turmeric oil and resin.

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“…In Curcuma species, Curcuma longa rhizome powder has been used for cough, wound healing from the ancient time. Among the scientific communities, various parts of C. longa have been proved to have an antioxidant [2], antibacterial [3], anticancer [4], hepatoprotective effects [5], and anti-inflammatory [6] potentials due to the presence of major bioactive principles such as α-turmerone and β-turmerone in essential oil extracted from C. longa rhizome [2], and it contains curcumin, demethoxycurcumin, and bisdemethoxycurcumin identified with high-performance liquid chromatography coupled with electrochemical detection methods [7]. Different organic solvents such as petroleum ether, chloroform, benzene, methanol, and aqueous fractions of C. longa demonstrated against Staphylococcus aureus found that petroleum ether and methanol fractions possess higher antimicrobial activity [8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Potentials and Simultaneous Estimation of Quercetin, Rutin, and Gallic Acid in Curcuma Species

Sangilimuthu

Karpagavalli

et al. 2017

Asian J Pharm Clin Res

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Objective: This study was designed to provide simple and cost-effective methods to quantify the biologically active phytoconstituents such as rutin, quercetin, and gallic acid from Curcuma species and evaluation of the antioxidant potential of different parts with different solvent extracts of Curcuma species.Methods: Ultraviolet-visible spectrophotometer was used for the analysis of quercetin, rutin, gallic acid and total flavonoid content of Curcuma species extracts. Antioxidant potential of Curcuma species extracts were evaluated using 2-2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.Results: Ethyl acetate extract of Curcuma aromatica rhizome, aerial part contain higher quantity of quercetin and rutin compared to the other extracts, and also Curcuma species such as Curcuma longa and Curcuma amada contains high antioxidant capacity. The total flavonoid content was high in ethyl acetate extract of Curcuma aromatica as 88.35±0.25 μg/g dry weight of quercetin equivalents. Conclusion:Different extracts of Curcuma species possess good free radical scavenging activity and the IC 50 of Curcuma amada aerial part, Curcuma longa aerial part, and Curcuma aromatica rhizome was 61.65±1.75, 62.95±1.85, and 89.40±0.15 (μg/ml), respectively. The Curcuma species contains high total flavonoid content and antioxidant potential.

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Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats

Cited by 70 publications

References 32 publications

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Antithrombotic activity of turmeric (<italic>Curcuma longa</italic>): A review

Turmeric (<i>Curcuma longa</i>): From a Variety of Traditional Medicinal Applications to its Novel Roles as Active Antioxidant, Anti-Inflammatory, Anti-Cancer and Anti-Diabetes

Antioxidant Potentials and Simultaneous Estimation of Quercetin, Rutin, and Gallic Acid in Curcuma Species

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