Hepatoprotective and Renoprotective Potentials of the Aqueous Extract of Bixa orellana on Streptozotocin Induced Diabetic Rats

Abstract

Objective: The present study was undertaken to evaluate the effects of the aqueous extract of Bixa orellana on the liver enzymes such as AST, ALT and ALP and also to evaluate the efficacy of the extract for the protection of the renal function in streptozotocin induced diabetic rats.Methods: Diabetes was induced by administering streptozotocin dissolved in saline while the normal control group was given propylene glycol. Diabetes induced animals were randomly assigned into different groups. Blood samples were collected from all the control and experimental group. Estimation of urea, uric acid and creatinine as well as the liver enzymes such as AST, ALT and ALP were assayed. These estimations were carried out on day 30 only. Results:The 30 days treatment with the aqueous extract (200 mg/kg body weight) showed no statistical significance with respect to urea and uric acid but there was statistical significance in the levels of creatinine which is an indicator of glomerular filtration rate. The alteration in the levels of ALT and ALP were highly significant statistically but no changes observed in the level of AST. Conclusion:The employed dose of the extract is nontoxic to the kidney and it even caused a significant decrease in level of liver enzymes when diabetic induced rat subjected to treatment hence this may indicate the hepatoprotective properties of this extract.

Phosphorylated chitosan accelerates dermal wound healing in diabetic wistar rats

“…Diabetes mellitus was induced according to the method of Bhat et al with minor modifications [ 22 ]. Briefly, prior to the induction of diabetes, rats were kept on fasting for 12 h followed by a single dose intraperitoneal injection of streptozotocin (50 mg/kg BW dissolved in 0.1 M cold citric acid buffer (pH 4.5).…”

Effect of Adding Annatto Seed Powder (Bixa orellana) and Astaxanthin to the Diet in the Productive Performance of Broilers(Ross-308)

“…[5][6][7]. Annatto seed (Bixa orellana L) commonly known as achiote, is a kind of shrubby plant from the tropics of America, belonging to the family Bixaceae, a pigment is extracted from of which it contains a high percentage of carotene consisting mainly of bixin and quantities of isobexin and norbexin [8], and most breeders prefer to use these seeds as they have a role as antimicrobials and antioxidants [9], In addition it is considered as anti-parasitic, protective, astringent, immune-boosting and antiseptic because of its phenolic compounds and vitamin E content [10][11][12]. European Food Safety Authority (EFSA) and Food and Allergy Committee (NDA) have both given its blessing to the use of the Haematococcus pluvialis alga-derived antioxidant astaxanthin in chicken feed [13,14].…”

Effect of Adding Annatto Seed Powder (Bixa orellana) and Astaxanthin to the Diet in some Physiological Traits of Broiler (Ross-308)

“…Annatto seeds Bixa orellana L known as achiote , is a species of tree plant from the tropics of America, belongs to the Bixaceae family, a pigment is extracted of which it contains a high percentage of carotene consisting mainly of bixin and amounts of isopixin and norbixin [8], and most breeders prefer to use these seeds as they have a role as antimicrobials and antioxidants [9]. In addition it is considered an immune booster due to its phenolic compounds and vitamin E content [10][11][12]. The European Food and Safety Authority (EFSA) and the Food and Allergy Committee (NDA) have issued permits for the use of astaxanthin extracted from Haematococcus pluvialis as a dietary supplement for humans and animals, specifically in the context of poultry diets, due to the product's demonstrated safety and validity in these applications [13,14].…”