2018
DOI: 10.4172/2167-0501.1000255
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Abstract: Objective: The present study was undertaken to evaluate the effects of the aqueous extract of Bixa orellana on the liver enzymes such as AST, ALT and ALP and also to evaluate the efficacy of the extract for the protection of the renal function in streptozotocin induced diabetic rats.Methods: Diabetes was induced by administering streptozotocin dissolved in saline while the normal control group was given propylene glycol. Diabetes induced animals were randomly assigned into different groups. Blood samples were … Show more

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Cited by 3 publications
(3 citation statements)
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“…Diabetes mellitus was induced according to the method of Bhat et al with minor modifications [ 22 ]. Briefly, prior to the induction of diabetes, rats were kept on fasting for 12 h followed by a single dose intraperitoneal injection of streptozotocin (50 mg/kg BW dissolved in 0.1 M cold citric acid buffer (pH 4.5).…”
Section: Methodsmentioning
confidence: 99%
“…Diabetes mellitus was induced according to the method of Bhat et al with minor modifications [ 22 ]. Briefly, prior to the induction of diabetes, rats were kept on fasting for 12 h followed by a single dose intraperitoneal injection of streptozotocin (50 mg/kg BW dissolved in 0.1 M cold citric acid buffer (pH 4.5).…”
Section: Methodsmentioning
confidence: 99%
“…[5][6][7]. Annatto seed (Bixa orellana L) commonly known as achiote, is a kind of shrubby plant from the tropics of America, belonging to the family Bixaceae, a pigment is extracted from of which it contains a high percentage of carotene consisting mainly of bixin and quantities of isobexin and norbexin [8], and most breeders prefer to use these seeds as they have a role as antimicrobials and antioxidants [9], In addition it is considered as anti-parasitic, protective, astringent, immune-boosting and antiseptic because of its phenolic compounds and vitamin E content [10][11][12]. European Food Safety Authority (EFSA) and Food and Allergy Committee (NDA) have both given its blessing to the use of the Haematococcus pluvialis alga-derived antioxidant astaxanthin in chicken feed [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…Annatto seeds Bixa orellana L known as achiote , is a species of tree plant from the tropics of America, belongs to the Bixaceae family, a pigment is extracted of which it contains a high percentage of carotene consisting mainly of bixin and amounts of isopixin and norbixin [8], and most breeders prefer to use these seeds as they have a role as antimicrobials and antioxidants [9]. In addition it is considered an immune booster due to its phenolic compounds and vitamin E content [10][11][12]. The European Food and Safety Authority (EFSA) and the Food and Allergy Committee (NDA) have issued permits for the use of astaxanthin extracted from Haematococcus pluvialis as a dietary supplement for humans and animals, specifically in the context of poultry diets, due to the product's demonstrated safety and validity in these applications [13,14].…”
Section: Introductionmentioning
confidence: 99%