Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats

Palanivel, Muthu Gounder; Balasubramanian, Kumar; Kumar, R. Senthil; Einstein, John Wilking; Kumar, E. P.; Kumar, Mani Rupesh; Kavitha, K.; Kumar, M Pradeep; Jayakar, B.

doi:10.3797/scipharm.0803-16

Cited by 85 publications

(54 citation statements)

References 22 publications

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“…Palanivel et al (2008) also noted a decrease in serum bilirubin following the administration of an alcohol extract of Pisonia aculeata and silymarin in rats receiving a hepatotoxic compound daily for 10 days. This compound is based on carbon tetrachloride, and resulted in a loss of membrane integrity of hepatocytes and liver cell function.…”

Section: Blood Parametersmentioning

confidence: 99%

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Casamassima¹,

Palazzo²,

Vizzarri³

et al. 2013

Czech J. Anim. Sci.

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ABSTRACT:Two different doses of a dietary verbascoside-based supplement were evaluated on various blood parameters and on productive performance in young weaned hares reared intensively from 28 to 90 days of age. The study lasted for 62 days and it was conducted on 210 young hares divided into three homogeneous groups of 70 animals each, consisting of a control group and two experimental groups. Each group received the dietary supplement in the feed, titrated to 0.5% verbascoside, 1 kg/t of concentrate (LVB group) and 2 kg/t of concentrate (HVB group). The experimental reliefs included the measurement of blood parameters such as triglycerides, total cholesterol, high density lipoprotein cholesterol, and bilirubin, along with some markers of oxidative status in plasma such as reactive oxygen metabolites, thiobarbituric acid-reactive substances, and vitamins A and E. Various productive parameters were also measured such as body weight and growth rate, food consumption, and feed conversion. The experimental treatment resulted in a significant decrease in triglycerides (P < 0.01) and bilirubin (P < 0.05) and an increase in high density lipoprotein cholesterol (P < 0.01) both in the low verbascoside (LVB) and high verbascoside (HVB) experimental groups. In addition, the oxidative plasma stability in blood also improved, with a significant decrease in the concentration of reactive oxygen metabolites (P < 0.01) and thiobarbituric acid-reactive substances (P < 0.01), along with increased levels of vitamin E (P < 0.05). The productive performance was not statistically influenced by the experimental treatment, except for the growth rate which increased significantly (P < 0.05) in the experimental LVB and HVB groups: 6.9% and 8.7% respectively compared with the control group.

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Section: Blood Parametersmentioning

confidence: 99%

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Casamassima¹,

Palazzo²,

Vizzarri³

et al. 2013

Czech J. Anim. Sci.

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“…Decreased levels of GSH are associated with an enhanced lipid peroxidation in CCl4 treated rats, which in turn gives rise to other products like malondialdehyde that extensively causes membrane damage. 37 The present study demonstrated that both the AVU and Silymarin pretreated groups significantly reduced the oxidative stress by recovering the decreased activities of SOD, CAT, GSH and reducing the levels of malondialdehyde in CCl4-induced acute liver injury. The anti-oxidant activity was higher with test group administered AVU at a dose of 400mg/kg body weight when compared to 200 mg/kg body weight.…”

Section: Vein (10x) B) Ccl4 Treated Group Rats Show Steatosis Centrmentioning

confidence: 73%

Hepatoprotective and in Vivo Antioxidant Potential of Aqueous Seed Extract of Vigna Unguiculata Against Carbon Tetrachloride Induced Hepatotoxicity in Rats

Gv¹,

Pullaiah²,

Dhanunjaya³

et al. 2017

Int. Res. J. Pharm.

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To evaluate the hepatoprotective and in vivo antioxidant effect of aqueous seed extract of Vigna unguiculata (AVU) against Carbon tetrachloride (CCl4) induced hepatic injury in rats. 30 male wistar rats were divided into five groups. Group 1 and 2 received plain groundnut oil (3ml/kg body weight p.o.) for 21 days and had free access to food and water. Group 3, 4 and 5 were pretreated with Silymarin (50 mg/kg body weight, p.o.) and AVU at a dose of 200 and 400 mg/kg body weight respectively for 21 days. Hepatotoxicity was induced by the intraperitoneal administration of a single dose of CCl4 (50% v/v in groundnut oil at a dose of 3 ml/kg body weight) in all groups except group 1 on 21 st day. Biochemical estimations were done on 22 nd day followed by harvesting of liver for antioxidant and histopathological studies. Changes in serum hepatic enzymes, total bilirubin, total protein, total cholesterol, total triglycerides and oxidant parameters induced by CCl4 administration were reversed by AVU treatment in a dose dependent manner and the same trend was observed with Silymarin treated group. The biochemical and antioxidant observations were paralleled by histopathological findings in rat liver both in the case of CCl4 and treatment groups. Pretreatment with AVU had significant protection against hepatic damage induced by CCl4 and hence can be used as a safe, cheap, and effective hepatoprotective agent a, supporting its folklore use.

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“…Gupta et al (2012) investigated presence of triterpenoides, saponins, tannins and flavonoids from stem bark. For acute oral toxicity studies, extract treated animals were observed for mortality up to 72 h. Based on the results, the treatment byextract was not produced any mortality up to 2000 mg/kg body weight in rats (Palanivel et al, 2008).…”

Section: Phytochemical and Safety Studiesmentioning

confidence: 99%

Effect of Careya arborea Roxb. on CCl4 induced liver damage in rats

Nanotkar¹,

Jangde²,

Jagtap³

et al. 2016

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The aqueous extract of bark of Careya arborea Roxb., locally known as Kumbhi, was screened for hepatoprotective activity against CCl 4 -induced hepatotoxicity in rats with a view to explore its application for treatment of liver disorders in animals and human beings. The hepatotoxicity induced by administration of carbon tetrachloride (CCl 4 ) as 30 % solution prepared in liquid paraffin and administered subcutaneously 1ml/kg b.wt. at every 72 h interval till the completion of experiment. The hepatotoxicity was found to be tolerated by simultaneous oral administration of aqueous extract of C. arborea (AECA) stem bark (100, 200 mg/kg b. wt.) for two weeks, with evidence of decreased level of AST, ALT, ALP and bilirubin. In addition, severe histomorphological disruption and fatty changes produced by CCl 4 in respect of cytoarchitecture were minimized and maintained by the treatment of extract. The results were compared with standard drug silymarine. The results of this study showed that AECA could afford hepatoprotective activity against CCl 4 induced liver damage in rats due to nutraceutical nature of plant.

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Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats

Cited by 85 publications

References 22 publications

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Effect of dietary phenylpropanoid glycoside-based natural extracts on blood parameters and productive performance in intensively-reared young hares

Hepatoprotective and in Vivo Antioxidant Potential of Aqueous Seed Extract of Vigna Unguiculata Against Carbon Tetrachloride Induced Hepatotoxicity in Rats

Effect of Careya arborea Roxb. on CCl4 induced liver damage in rats

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