Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin

Abstract

Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.

Identification of Major Flavonoids in Petals of Edible Chrysanthemum Flowers and Their Suppressive Effect on Carbon Tetrachloride-Induced Liver Injury in Mice

“…As some flavonoids contained in tea and herbs have been found to be effective in preventing liver injury (Wada et al, 2000;Murakami et al, 2004), further investigation of major flavonoids contained in petals of the edible chrysanthemum flower (Chrysanthemum×morifolium Ramat. forma esculentum Makino, c.v Kotobuki) and their physiological functions is of great interest.…”

Comparison of the Preventive Activity of Isorhamnetin Glycosides from Atsumi-kabu (Red Turnip,Brassica, campestrisL.) Leaves on Carbon Tetrachloride-Induced Liver Injury in Mice

“…[1][2][3] Consequently, many physiological functions of flavonoids, such as their preventive effects on cancer, cardiovascular disease, liver injury and oxidative stress, neuroprotective effects, and hypoglycemic effects, have been investigated and reported, [4][5][6][7][8][9][10][11] and the bioavailability, absorption from the gastro-intestinal tract, and metabolism of flavonoids have been examined in relation to their function. [12][13][14] However, few reports have been presented on the precise relationship between the chemical structure of dietary flavonoids and their bioavailability or functions.…”

Antioxidant Flavonoids from the Twigs of Stewartia koreana

“…Among six isolated compounds, compound 1 exhibited higher activity with IC 50 value of 2.6 μg/ml than vitamin C, used as a positive control (IC50 value, 6.4 μg/ml) (Table IV). It was reported that compound 1, ampelopsin has protective effect on oxidant stress-induced apoptosis induced by H2O2 in MT-4 cells, antitumor effects, inhibitory effects on angiogenesis, and hepatoprotective activity (Murakami et al, 2004;Zeng et al, 2004;Luo et al, 2006;Ye et al, 2008). The results from free radical scavenging systems revealed that the ethyl acetate soluble fraction of S. koreana, and isolated compounds 1-3 may be useful for the treatment of various oxidative damage.…”