Hepatoma presenting as a cerebellar metastasis

Brunner, Douglas R.; Dunne, Morgan G.; Rao, K. Chowdoji; Sutherland, John C.; Cisternino, Stephan J.

doi:10.1016/0149-936x(82)90015-7

Cited by 6 publications

(4 citation statements)

References 3 publications

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“…Most of the literature on metastatic HCC originates from Asian countries but only a few cases of brain metastases in Caucasians have been reported. 9,12,[16][17][18][19] To our knowledge, these are the first two reported cases of hepatocellular brain metastases occurring in Caucasians outside Europe and the USA.…”

Section: Discussionmentioning

confidence: 99%

Brain metastases from hepatocellular carcinoma in two Caucasian Australian patients

Shapey¹,

Li²,

Gonzalès³

et al. 2012

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Brain metastases from hepatocellular carcinoma in two Caucasian Australian patients

Shapey¹,

Li²,

Gonzalès³

et al. 2012

Journal of Clinical Neuroscience

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“…In autopsy series, brain metastases were found in 1.3% in Japan [6] . In contrast, an American survey of 482 cases of intracranial metastases by the University of Maryland and John Hopkins University did not find a single case of metastatic HCC [7] . With the diffuse presence of tumors around the spinal cauda equina, intraspinal dissemination from the metastatic brain tumor appeared to be likely.…”

Section: Right Leftmentioning

confidence: 93%

A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings

Tamaki

Shimizu²,

Urata³

et al. 2007

WJG

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Although spinal tumors are uncommon, they may reduce survival or cause serious functional disorders in the extremities. Metastatic spinal tumors from malignant tumors can induce symptoms of spinal cord compression, such as paraplegia, quadriplegia, and vesicorectal disturbance, which are aggravated with progression of the diseases and time. We report a patient with hepatocellular carcinoma (HCC) who was suspected of having spinal lesions based on neurological findings, and a metastatic spinal tumor was found by imaging examination. Assuming that metastasis had occurred at the time lumbar pain developed, the patient reached the level of gait disturbance within only 4 mo, showing a rapid advancement of symptoms. If early diagnosis had been possible, treatment could be performed before acute myelopathy progressed to complete paralysis. We speculate that the terminal stage of HCC is not only liver failure associated with intrahepatic lesions but also metastasis to other regions, treatment for individual pathologies therefore, will be needed, which constitutes an important issue.

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“…may adversely effect CNS function [Ill. A specific neurologic paraneoplastic syndrome has only been described once in HCC and consisted of cerebellar atrophy 11 11. tumor recurrence. A total of 19 such cases are summarized in Table I [2,6,7,. Their ages ranged from 25-74 years (average, 51 years), with a male to female ratio of 16:3.…”

Section: Hcc and The Central Nervous Systemmentioning

confidence: 99%

“…prevalence in Asia that HCC accounts for 0.8% of all central nervous system tumors in Japan [6] and 1.8% in Taiwan [2]. In contrast, an American survey of 482 consecutive cases of intracranial metastases from the University of Maryland and John Hopkins University did not include a single case of metastatic HCC [7].…”

mentioning

confidence: 99%

Hepatocellular carcinoma with central nervous system metastasis: A case report and literature review

Friedman

1991

Med. Pediatr. Oncol.

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In the United States and western Europe, hepatocellular carcinoma is not generally regarded as a distantly metastasizing tumor. The ability of hepatocellular carcinoma to metastasize to the brain is illustrated by the example of a 65-year-old white American man with no identifiable risk factors for primary liver cancer. Though hepatocellular carcinoma rarely metastasizes to the central nervous system, such metastases are reported to have led to tumor diagnosis or signaled tumor relapse.

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Hepatoma presenting as a cerebellar metastasis

Cited by 6 publications

References 3 publications

Brain metastases from hepatocellular carcinoma in two Caucasian Australian patients

Brain metastases from hepatocellular carcinoma in two Caucasian Australian patients

A patient with spinal metastasis from hepatocellular carcinoma discovered from neurological findings

Hepatocellular carcinoma with central nervous system metastasis: A case report and literature review

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