Hepatocytes Derived From Adult Stem Cells

Stock, Peggy; Staege, Martin S.; Müller, Lutz; Sgodda, Malte; Völker, Angelica; Volkmer, Ines; Luetzkendorf, Jana; Christ, Bruno

doi:10.1016/j.transproceed.2008.01.058

Cited by 60 publications

(41 citation statements)

References 17 publications

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“…During liver differentiation, numerous liver transcription factors as well as numerous cytoplasmic proteins are expressed selectively and can be detected using microarray analysis. Analysis of the hepatocyte-like cells derived from MSCs Show a numerous change in the gene expression profile, which is relatively similar to those of adult and fetal hepatocytes [34].…”

Section: Characterization Of Hepatocyte-like Cells Derived From Mscsmentioning

confidence: 93%

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Mesenchymal Stem Cells as a Potential Source of Hepatocyte like Cells

Othman

Hassan²

2016

J Bone Marrow Res

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The field of regenerative medicine is growing up rapidly in the last decades, the usage of cellular therapy such as stem cells start to grasp attention in many experimental and even clinical trial.In this article, we mainly concentrate on the potentiality of the mesenchymal stem cell (MSC) to differentiate into hepatocyte like cells, which can overcome the problem of donor's shortage. MSC have been use lately in many in vitro and in vivo experiments, and have showed great capacity of multilinage differentiation, interestingly they have the capacity to differentiate into hepatocyte like cells. Currently many clinical trials started to involve the usage of self-MSC as a novel therapy for hepatic complication such as fibrosis or cirrhosis, which showed promising results in treatment of hepatic patients. MSC can be injected in hepatic patient to replace the cirrhotic liver, which gives a real hope for the hepatic patients as a reliable source for regeneration.

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Section: Characterization Of Hepatocyte-like Cells Derived From Mscsmentioning

confidence: 93%

“…In addition to these well characterized methods, more subtle molecular biological approaches have been subjugated recently in the evaluation of hepatocyte like cell differentiation from MSCs [34].…”

Section: Characterization Of Hepatocyte-like Cells Derived From Mscsmentioning

confidence: 99%

Mesenchymal Stem Cells as a Potential Source of Hepatocyte like Cells

Othman

Hassan²

2016

J Bone Marrow Res

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show abstract

“…These findings led to a great deal of debate as to whether MSC can actually generate hepatocytes or if, perhaps, all the effects they produce are simply mediated through release of soluble factors. Meticulously executed in vitro studies have now provided definitive evidence that MSC can under appropriate conditions be reprogrammed into cells with all of the characteristics of functional hepatocytes that can currently be assessed in culture [37,135,[148][149][150][151]. Thus, it is now presumed that if these hepatocyte induction protocols work well in cultured MSC, in vivo organ-specific microenvironment of the recipient liver is likely to be even better suited for inducing the transplanted MSC to differentiate into hepatocytes.…”

Section: Mesenchymal Stem Cells Differentiate In Vivo Into Hepatocytesmentioning

confidence: 99%

Potential of Mesenchymal Stem Cells for Liver Regeneration

Soland¹,

Porada²,

Almeida‐Porada³

2012

Liver Regeneration

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“…These cells showed to be viable and engrafted into liver lobules. Moreover, transplantation of differentiated and undifferentiated MSC was compared with prevalence of predifferentiation to facilitate long term functional hepatic integration in vivo (74,75).…”

Section: Clinical Cytomics In Differentiation Andmentioning

confidence: 99%

Cytomics and nanobioengineering

Pierzchalski¹,

Robitzki²,

Mittag³

et al. 2008

Cytometry Part B Clinical

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The finding that an individual's genome differs as much as by many million variants from that of the human reference assembly diminished the great enthusiasm that every disease could be predicted based on nucleotide polymorphisms. Even individual cells of an organ may be specifically equipped to perform specific tasks and that the information of individual cells in a cell system is key information to understand function or dysfunction. Therefore, cytomics received great attention during the last years as it allows to quantitatively and qualitatively analyzing great number of individual cells, cell constituents, and of their intracellular and functional interactions in a cellular system and also giving the concept of analysis of these data.Exhaustive data extraction from multiparametric assays and multiple tests are the prerequisite for prediction of drug toxicity. Cytomics, as novel approach for unsupervised data analysis give a chance to find the most predictive parameters, which describe best the toxicity of a chemical. Cytomics is intrinsically connected to drug development and drug discovery.Focused on small structures, nanobioengineering is the ideal partner of cytomics, the systems biological discipline for cell population analysis. Realizing the idea ''from the molecule to the patient'' develops and offers chemical compounds, proteins, and other biomolecules, cells as well as tissues as instruments and products for a wide variety of biotechnological and biomedical applications.The integrative nanobioengineering combining different disciplines of nanotechnology will promote the development of innovative therapies and diagnostic methods. It can improve the precision of the measurements with focus on single cell analysis. By nanobioengineering and whole body imaging techniques, cytomics covers the field from molecules through bacterial cells, eukaryotic tissues, and organs to small animal live analysis. Toxicological testing and medical drug development are currently strongly broadening. It harbors the promise to substantially impact on various fields of biomedicine, drug discovery, and predictive medicine.As the number of scientific data is rising exponentially, new data analysis tools and strategies like cytomics and nanobioengineering take a lead and get closer to application. Bionanoengineering may strongly support the quantitative data supply, thus strengthening the rationale for cytomics approach. q

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Hepatocytes Derived From Adult Stem Cells

Cited by 60 publications

References 17 publications

Mesenchymal Stem Cells as a Potential Source of Hepatocyte like Cells

Mesenchymal Stem Cells as a Potential Source of Hepatocyte like Cells

Potential of Mesenchymal Stem Cells for Liver Regeneration

Cytomics and nanobioengineering

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