Hepatocyte-targeted delivery using oleanolic acid-loaded liposomes for enhanced hepatocellular carcinoma therapy

Wei, Xinbo; Yang, Depeng; Zheng, Xiaohui; Cai, Jialing; Wang, Li; Zhao, Chen; Wei, Xingmei; Jiang, Ming; Sun, Handi; Zhang, Lu; Fan, Ya Ju; Nie, Huan; Liu, Haifeng

doi:10.1039/d3bm00261f

Cited by 6 publications

(1 citation statement)

References 51 publications

(61 reference statements)

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“…In mouse Hepa1-6 cells, OA-loaded GC@Lipo inhibited migration and proliferation, upregulating E-cadherin and downregulating N-cadherin, vimentin, and Anexelekto compared to free OA solution and OA-loaded liposomes. In an axillary tumor xenograft mouse model, OA-loaded GC@Lipo reduced tumor progression, concentrating in hepatocytes [ 128 ]. An investigation was carried out to address the health risks posed by airborne fine particulate matter (PM2.5), particularly in manual laborers who are exposed to both PM2.5 and alcohol.…”

Section: Challenges In Oa Deliverymentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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The growing interest in oleanolic acid (OA) as a triterpenoid with remarkable health benefits prompts an emphasis on its efficient use in pharmaceutical research. OA exhibits a range of pharmacological effects, including antidiabetic, anti-inflammatory, immune-enhancing, gastroprotective, hepatoprotective, antitumor, and antiviral properties. While OA demonstrates diverse pharmacological effects, optimizing its therapeutic potential requires overcoming significant challenges. In the field of pharmaceutical research, the exploration of efficient drug delivery systems is essential to maximizing the therapeutic potential of bioactive compounds. Efficiently delivering OA faces challenges, such as poor aqueous solubility and restricted bioavailability, and to unlock its full therapeutic efficacy, novel formulation strategies are imperative. This discussion thoroughly investigates different approaches and advancements in OA drug delivery systems with the aim of enhancing the biopharmaceutical features and overall efficacy in diverse therapeutic contexts.

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Section: Challenges In Oa Deliverymentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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ERH gene knockdown inhibits the proliferation and migration of ARPE-19 cells through MCM complex and EMT process

Li,

Zhang,

Guan

et al. 2024

Gene

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Recent advances of novel targeted drug delivery systems based on natural medicine monomers against hepatocellular carcinoma

Ji,

Li,

Zhang

et al. 2024

Heliyon

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Hepatocyte-targeted delivery using oleanolic acid-loaded liposomes for enhanced hepatocellular carcinoma therapy

Abstract: Drug-loaded liposomes have been shown to be effective in the treatment of hepatocellular carcinoma (HCC). However, the systemic non-specific distribution of drug-loaded liposomes in tumor patients is a critical therapeutic...

Cited by 6 publications

References 51 publications

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

ERH gene knockdown inhibits the proliferation and migration of ARPE-19 cells through MCM complex and EMT process

Recent advances of novel targeted drug delivery systems based on natural medicine monomers against hepatocellular carcinoma

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