Hepatocellular carcinoma: Epidemiological profile from a cohort of federal employees in Mexico

Guevara, Laura Ladrón de; Rojas-Macuil, Paulo Roberto; Sánchez-Chávez, Xochiquetzal; Rossano-García, Alejandro; Gorraez-de-la-Mora, Ma. Teresa; Cervantes-Sánchez, Guadalupe; Orozco-Vázquez, Julita; Lemus-Velázquez, Mario; Rosas-Zúñiga, Leticia; Erazo-Valle, Aura; DiSilvio, Mauricio

doi:10.1016/s1665-2681(19)31768-5

Cited by 17 publications

(8 citation statements)

References 17 publications

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“…In a recent study in a cohort of Mexican federal employees, a 5% increase per year in referrals for HCC was observed. The majority of patients presented with cirrhosis (72.3%), and HCV infection was also a common factor (44.7%) [55]. In Mexico, HBV infection is not considered to be an endemic problem, and the prevalence of HBV infection in HCC cases is low, at 8.4% [56].…”

Section: Challenges In Hcc Epidemiologymentioning

confidence: 99%

The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

et al. 2010

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Section: Challenges In Hcc Epidemiologymentioning

confidence: 99%

The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

et al. 2010

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“…The age range of the adult patients was 16 to 87 years. In 7 studies, cirrhosis was present among liver biopsy or autopsy of HCC cases [20][21][22][23][24][25]31,33]. In these cases, cirrhosis was attributed either to alcohol or viral hepatitis.…”

Section: Demographic and Clinical Data In Mexican Hcc Patientsmentioning

confidence: 99%

“…However, to fully support this conjecture, further updated prospective studies beginning at earlier stages of disease, i.e., in pre-cirrhotic or cirrhotic patients from different regions are required, together with a national-based incidence registry system for HCC cases. Table 3 depicts the facts regarding the relative frequency of the risk factors associated to HCC that was extracted from 6 studies [20,24,25,[31][32][33]. Few studies reported seroprevalence of viral markers; from a total of 530 HCC cases, the seropositivity for HBsAg, anti-HCV, or both markers was 11%, 66% and 2.2% respectively.…”

Section: Reported Incidence Of Hcc In Mexicomentioning

confidence: 99%

“…In 11% of the HCC cases was HBsAg detected, however, HBV was not reported as the primary etiological agent of the 6 studies detailed in Table 3. To explain this high proportion of HCV-HCC related cases, we already have emphasized the discrepancy between the pre- [20]: congenital (n = 2) and unidentified factors (n = 8), [33]: diabetes mellitus (n = 7), no risk factors (n = 7), missing data (n = 12).…”

Section: Relative Frequencies Of Hbv Hcv Infection and Alcohol Abusementioning

confidence: 99%

“…In this situation, HCC may not be diagnosed with a histopathological confirmation that could allow distinguishing primary liver cancers from secondary metastasis of malignancy, thus leading to an equivocal registration of HCC on the death certificate. Yet another situation could be that diagnosis and certification of primary liver cancer may be influenced by increased surveillance of cirrhotic patients through different imaging techniques, which may lead to an apparent increase in the incidence of HCC [33,62].…”

Section: Reported Mortality Rates Of Hcc In Mexicomentioning

confidence: 99%

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Hepatitis B Virus Genotype H and Environmental Factors Associated to the Low Prevalence of Hepatocellular Carcinoma in Mexico

Román¹,

Fierro²,

Moreno-Luna³

et al. 2013

JCT

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Purpose: Hepatocellular carcinoma (HCC) is a leading health problem worldwide. Any agent causing chronic liver damage and cirrhosis is a risk factor for HCC. Genetic and environmental factors may be responsible for regional variations in the occurrence of HCC worldwide. The aim of this review was to describe the risk factors that may be contributing to low prevalence of HCC in the Mexican population. Methods: An electronic systematic search was conducted in four databases to retrieve studies on hepatocellular carcinoma inMexico. Results: Eighteen publications gave a total of 1042 HCC cases with a percentage that ranged from 0.25% to 1.87%. Cirrhosis was registered in 7 studies while the main etiologies were: HCV (66%), HBV (11%) and alcoholism (6.6%). Conclusions: In the last 50 years, the studies performed inMexicohave shown a very low incidence and/or mortality rate of HCC. These findings contrast from those reported in high endemic regions, such asAsia, where viral hepatitis and HCC are prevalent. One significant difference is the predominance of HBV genotype H in Mexico and HBV/B and C in Asia. InMexico, high endemic areas of HBV infection have been detected, mainly among the native population; however, infection seems to resolve very quickly, due to a prominent immunological response among the population. Other factors are that patients with liver cirrhosis die prematurely before that HCC can be detected. Furthermore, an environmental factor that may exert a protective effect against HCC, in spite of the high consumption of potentially aflatoxin-contaminated food products, is the neutralization of these substances by alkaline treatment. This study shows that genetic and environmental factors associated to HCC among the Mexican population are different from others reported worldwide.

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Hepatocellular Carcinoma in Mexico

Garza

Haddad

2022

Clinical Liver Disease

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Hepatocellular carcinoma: Epidemiological profile from a cohort of federal employees in Mexico

Cited by 17 publications

References 17 publications

The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

Hepatitis B Virus Genotype H and Environmental Factors Associated to the Low Prevalence of Hepatocellular Carcinoma in Mexico

Hepatocellular Carcinoma in Mexico

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