Hepatitis E virus seroprevalence in haemodialysis patients in Zanjan province, Islamic Republic of Iran

Ar, Mobaien; Mohammadi, Rasool; Sorouri, Rahim; Sadeghi, Kaveh

doi:10.26719/2013.19.7.608

Cited by 12 publications

(11 citation statements)

References 23 publications

(23 reference statements)

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“…The results from seroepidemiological surveys at Zanjan, Jahrom and Ahvaz showed various results like 26.9%, 7%, and 10.6%, respectively ( 11 - 13 ). Our findings are higher than the rate observed in Jahrom and lower than that of Zanjan.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis E Among Hemodialysis Patients: a Report From Hamadan, Iran

2015

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Background:Previous studies have documented a high prevalence of hepatitis E among patients undergoing maintenance hemodialysis. Available studies reporting on the seroprevalence of hepatitis E in hemodialysis patients in Iran, an endemic region for the disease, are sparse.Objectives:The present study aimed to determine the prevalence rate of anti-hepatitis E antibody in hemodialysis patients in Hamadan, Iran.Patients and Methods:In this cross-sectional study, all 153 consecutive patients undergoing hemodialysis in two centers were enrolled. Patients’ demographic and clinical data were collected, using a standard questionnaire and from medical records. Serum immunoglobulin G concentrations against hepatitis E were determined using the enzyme linked immunosorbent assay method.Results:Thirty patients (19.2%), were seropositive. Seropositive patients were not significantly different from seronegative patients, with regard to age, sex, level of education, access to filtered water, and duration and frequency of hemodialysis. The proportions of patients with hepatitis B, C, and HIV infection were comparable between the two groups.Conclusions:One in five patients undergoing maintenance dialysis in Hamadan is seropositive for hepatitis E immunoglobulin G antibody. Future studies are needed to investigate the factors contributing to the observed high prevalence rate and the possibility of parenteral transmission of hepatitis E.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis E Among Hemodialysis Patients: a Report From Hamadan, Iran

2015

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“…Finally, after further assessments, 54 studies relevant to HCV prevalence in Iranian HD patients remained in our list [ Figure 1 ]. [ 4 7 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 ]…”

Section: Resultsmentioning

confidence: 99%

“…In Iran, comparing to the general population, there are higher detected prevalence of HCV infection in HD patients that across the different provinces HCV prevalence show considerably variation from 5.5% to over 24%. [ 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 ]…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis C infection in Iranian hemodialysis patients: An updated systematic review and meta-analysis

et al. 2017

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Background:Hepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality. This study aims to provide a comprehensive evidence on HCV Infection in Iranian hemodialysis (HD) patients we conducted a systematic review.Materials and Methods:In this systematic review and meta-analysis, through a comprehensive search of literature until January of 2016, we estimated the pooled prevalence of hepatitis C infection in Iranian HD patients. Using Medical Subject Headings terms, Emtree, and related equal Persian key words for Iranian databases and also international databases of PubMed and NLM Gateway (for MEDLINE), and SCOPUS. Interest outcome of HCV infection prevalence was confirmed based on positive hepatitis B surface antigen of blood samples. Random effect meta-analysis was used to estimate pooled prevalence of HCV infection in Iranian HD patients, date and language, HD patients, in adult HD patients, Institute of Scientific Information, Iran-doc, irrespective of age, living in Iran. Searches run through main domestic databanks of Iran-Medex, renal transplantation, Scientific Information Database, the relevant literature-searched concentrating on HCV infection.Results:Through searching steps, 305 publications were found from them following the excluding duplicates and overlapping studies 54 studies relevant to HCV prevalence in Iranian HD zcxw patients, with number of 23921 participants, remained in our analyses. The overall results of test of heterogeneity demonstrate sever heterogeneity between reported prevalence (I2 = 96.62%, Chi-square = 1566, P < 0.001). Due to sever heterogeneity results of random effect meta-analysis showed that the estimated pooled prevalence was 11% (95% confidence interval [CI] =10%–13%). The pooled prevalence base on polymerase-chain reaction, recombinant immunoblot assay, and enzyme-Linked Immunosorbant Antibody method were 11% (95% CI = 6%–15%), 9% (95% CI = 5–13) and 12% (95% CI = 10–14), respectively. In line with previous studies, the present finding shows the significant variation in the rate of HCV in dialysis units among the regions in Iran.Conclusion:Present paper is the comprehensive updated systematic review on HCV prevalence in the Iranian HD patients. Our findings provide the reliable evidence for promotion of policies and interventional programs.

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“… 18 , 19 Higher HEV prevalence has also been noted in dialysis patients in HEV endemic areas, which increases the prevalence of dual HEV-HBV infections. 20 …”

Section: Epidemiologymentioning

confidence: 99%

HEV and HBV Dual Infection: A Review

Nasir¹,

Wu²

2020

Journal of Clinical and Translational Hepatology

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Hepatitis E virus (HEV) is a global health problem, affecting about 20 million people worldwide. There is significant overlap of hepatitis B virus (HBV) and HEV endemicity in many Asian countries where dual infections with HEV and HBV can occur. Though the clinical course of HEV is largely self-limited, HEV superinfection in patients with chronic hepatitis B (CHB) can result in acute exacerbation of underlying CHB. HEV superinfection in patients with CHB-related cirrhosis has been identified as a risk factor for decompensated cirrhosis and an independent predictor of mortality. Whereas acute HEV infection in pregnancy can cause fulminant liver failure, the few studies on pregnant patients with dual HBV and HEV infection have shown a subclinical course. Immunosuppression is a risk factor for the development of chronic HEV infection, which can be managed by decreasing the dose of immune-suppressants and administering ribavirin. Vaccination for HEV has been developed and is in use in China but its efficacy in patients with CHB has yet to be established in the USA. In this review, we appraise studies on dual infection with HEV and HBV, including the effect of HEV superinfection and coinfection in CHB, management strategies used and the role of active vaccination in the prevention of HEV.

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Hepatitis E virus seroprevalence in haemodialysis patients in Zanjan province, Islamic Republic of Iran

Cited by 12 publications

References 23 publications

Seroprevalence of Hepatitis E Among Hemodialysis Patients: a Report From Hamadan, Iran

Seroprevalence of Hepatitis E Among Hemodialysis Patients: a Report From Hamadan, Iran

Prevalence of hepatitis C infection in Iranian hemodialysis patients: An updated systematic review and meta-analysis

HEV and HBV Dual Infection: A Review

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