Hepatitis E virus infection in selected Brazilian populations

Abstract

A retrospective study on the prevalence of hepatitis E virus (HEV)

Hepatite E

“…Encontrou-se o anti-VHE IgG em: 2,1% dos pacientes com hepatite aguda não B/não C; 6,2% dos pacientes em hemodiálise crônica; 4,3% dos doadores de sangue; 11,8% dos drogaditos; e 1% em mulheres grávidas 40 .…”

Hepatitis E seroprevalence and associated factors in rural settlers in Central Brazil

“…Meanwhile, residents in rural areas in Rio de Janeiro (Sumidouro) had a similar seroprevalence (2.1%; 95% CI, 0.5-6.4) 7 . Regarding studies conducted in rural populations in Latin America, similar anti-HEV IgG prevalence rates were also reported in Bolivia (6.3%; 95% CI, 3.6-10.3) 11 and Venezuela (5.4%; 95% CI, 2.9-9.4) 12 , but a higher rate was reported in Mexico (36.6%; 95% CI, 31.0-42.7) 13 .…”

“…However, these areas have adverse conditions for life and health, such as inadequate disposal of waste, inadequate access to drinkable water, and overcrowding at home, favoring the emergence of diseases transmitted by the fecal-oral route. Besides, very little is known about the seroepidemiology of HEV infection in rural residents in Brazil 3,7 , with just one study conducted on agricultural settlers in the Amazon Region 4 . Until recently, only HEV genotype 3 (zoonotic) has been reported in Brazil 8,9 .…”

“…The study sample was estimated according to the population size (approximately 2,500 residents) and based on an expected HEV prevalence of 2.1% 7 , alpha and beta errors of 5% and 20%, respectively, precision of 1.5%, and design effect of 1.5%. The minimum sample size necessary would be 462 individuals.…”

Estimativa de áreas de risco para hepatite A

“…A susceptibilidade é universal, sem diferenças entre os sexos e raças. Em função de a alta prevalência estar associada a precárias condições sócio-econômicas, principalmente, de higiene e de saneamento 8,9,10,11 , constituise em um indicador de condições sanitárias da população. Assim, a melhoria dessas condições pode reduzir a transmissão pessoa a pessoa, diminuindo sua força de infecção 12 contra o vírus da hepatite A (anti-HAV) são detectados no sangue e a soroprevalência aumenta com a idade 13,14 .…”