Hepatitis C virus seroprevalence in multi-transfused patients in Colombia

Beltrán, Mauricio; Navas, María Cristina; Hoz, Fernando de la; Muñoz, María Mercedes; Jaramillo, Sergio; Estrada, Cecilia; Cortés, Lucía del Pilar; Arbeláez, María Patricia; Donado, Jorge; Barco, Gloria; Luna, M.; Uribe, Gustavo Adolfo Molina; Maldonado, Amalia de; Restrepo, Juan Carlos; Correa, Gonzalo; Borda, Paula; Rey, Gloria; Neira, M; Estrada, Andrés Felipe; Yepes, Sandra; Beltran, Oscar; Pacheco, J.A. de Freitas; Villegas, Iván; Bóshell, Jorge

doi:10.1016/s1386-6532(05)80032-0

Cited by 32 publications

(32 citation statements)

References 12 publications

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“…En Colombia, se ha determinado la prevalencia de la enfermedad en algunos grupos de riesgo, y se ha observado un incremento de los casos en quienes recibieron transfusiones antes de 1994 (6,7), en pacientes con enfermedad renal crónica terminal (8), en adictos al uso de drogas por vía parenteral (9,10), entre el personal sanitario (11,12) y en población indígena (12,13). Sin embargo, la persistente búsqueda de personas infectadas en los grupos de riesgo tradicionales no ha permitido detectar otros factores potencialmente implicados en el contagio.…”

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Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control study

Yepes

Lince

Caez³

et al. 2016

biomedica

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Contribución de los autores:Ismael de Jesús Yepes: coordinación del protocolo de investigación y análisis de la información Todos los autores participaron en el diseño del protocolo, la selección de pacientes y la redacción del manuscrito.Factores de riesgo para la infección por el virus de la hepatitis C en la Costa Caribe colombiana: un estudio de casos y controles Introducción. Se estima que, aproximadamente, 6,8 a 8,9 millones de personas están infectadas por el virus de la hepatitis C en Latinoamérica, de las cuales menos del 1 % llega a recibir tratamiento antiviral. En los estudios llevados a cabo hasta ahora en Colombia, se ha propuesto determinar la prevalencia de la enfermedad en algunos grupos de riesgo, y no se ha hecho el análisis de otros factores potencialmente implicados en el contagio. Objetivos. Determinar los factores de riesgo tradicionalmente analizados y otros no estudiados antes para la hepatitis C crónica en la Costa Caribe colombiana. Materiales y métodos. Se hizo un estudio de casos y controles (1:3) emparejados por empresa promotora de salud y edad (± 10 años), en el primer nivel de atención de hepatología y gastroenterología. A todos los pacientes positivos en la prueba ELISA se les hizo una prueba confirmatoria de carga viral. En el análisis de regresión logística multivariable se determinaron los factores predictores independientes de infección. Resultados. La transfusión sanguínea (odds ratio, OR=159,2; IC 95% 35,4-715; p<0,001) y el antecedente de hospitalización antes de 1994 (OR=4,7; IC 95% 1,3-17,1; p=0,018) se determinaron como los dos únicos factores independientes predictores de infección. Conclusión. Es necesario comprobar la reproducibilidad de estos resultados y hacer estudios de costo-efectividad antes de recomendar su utilización en el diseño de nuevas estrategias de cribado.Palabras clave: hepatitis C; factores de riesgo; estudios de casos; transfusión sanguínea; región del Caribe; Colombia. doi: http://dx.doi.org/10.7705/biomedica.v36i4.3105 Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control studyIntroduction: An estimated 6.8-8.9 million people are infected with hepatitis C virus in Latin America, of which less than 1% receives antiviral treatment. Studies so far in Colombia have attempted to determine the prevalence of the disease in some risk groups, thus preventing the identification of other factors potentially involved in the spread of the infection. Objectives: To identify traditional and non-traditional risk factors for chronic hepatitis C in the Colombian Caribbean coast. Materials and methods: This was a case-control study (1:3) matched by health care provider and age (± 10 years) conducted at the primary care level of gastroenterology and hepatology outpatient services. All patients with a positive ELISA underwent a confirmatory viral load test. A multivariate logistic regression analysis identified the independent predictors of infection. Results: Blood transfusion (OR=159.2; 95% CI: 35.4-715; p<0.001) and history...

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Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control study

Yepes

Lince

Caez³

et al. 2016

biomedica

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“…The prevalence of HCV in multi-transfused patients is 9% [7], whereas a more recent study carried out in 697 inhabitants from four different states showed a frequency of anti-HCV markers of 3.55% [8]. On the other hand, the prevalence of HBV in Colombia ranges between 1.97 and 8.39% in several regions [8][9][10].…”

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confidence: 99%

Hepatitis B and C prevalence among heroin addicts in methadone maintenance treatment (MMT) and not in MMT in Pereira, Colombia

Sepúlveda-Arias

Isaza

Vélez³

2014

J Infect Dev Ctries

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“…Recent studies of SCA patients show that the prevalence of anti-HCV varied (4.5 to 21%) (2,(11)(12)(13), which suggests that the geographical area may affect the potential risk of HCV in patients (17)(18)(19). Moreover, one of the most common causes of HCV transmission by transfusion is the occurrence of new infections in blood donors.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with SCA require multiple blood transfusions and therefore are exposed to transfusion-transmitted infections (TTIs) such as hepatitis B virus (HBV) and particularly hepatitis C virus (HCV). Regular blood or blood products transfusion in patients with sickle cell anemia, thalassemia and haemophilia has improved their overall survival, but carries a definite risk of acquisition of blood-borne virus infections (1)(2)(3)(4)(5). Improvement of the people's knowledge about TTIs risk factors, blood screening strategies, national HBV vaccination program since 1992 for all neonates have led to a dramatic decrease in the prevalence ofTTIs particularly HBV during the last decades (6,7).…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C Infections and Different Genotypes of HCV Among Sickle Cell Anemia Patients in Ahvaz, South-Western Iran

Ghafourian-Boroujerdnia

Assarehzadegan

Zandian

2013

Jundishapur J Microbiol

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Background:Although it is life-saving, blood transfusion therapy has resulted in risk for transfusion-transmitted infections (TTIs) in the majority of sickle cell anemia being patients. Objectives: The current study aimed to determine the prevalence of HBV, HCV and different genotypes of HCV among sickle cell anemia (SCA) patients in Ahvaz city, South-western Iran. Materials and Methods: A cross-sectional study was conducted on 56 SCA patients who referred to the Hemoglobinopathy and Thalassemia research centre during January 2009 to February 2010. Patients` sera were tested for HBsAg and anti-HCV using ELISA and confirmed by PCR (HBV) and RT-PCR (HCV). HCV genotypes were determined with HCV genotype specific primers using HCV genotyping kit. Results:The overall prevalence rate of HBsAg and anti-HCV were 1.8% (95% CI: 0-5.26) and 12.5% (95% CI: 3.8 -21.1), respectively. Five of the anti-HCV patients (71.4%) were also HCV RNA positive. The predominant HCV genotype in the patients was 1a (60%), though genotype 1b was found in 40% of the subjects. Conclusions: It seems that stringent donor selection procedures reduce HCV infection in multi-transfused patients, but there is still serious risk for these patients.

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Hepatitis C virus seroprevalence in multi-transfused patients in Colombia

Cited by 32 publications

References 12 publications

Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control study

Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control study

Hepatitis B and C prevalence among heroin addicts in methadone maintenance treatment (MMT) and not in MMT in Pereira, Colombia

Hepatitis B and C Infections and Different Genotypes of HCV Among Sickle Cell Anemia Patients in Ahvaz, South-Western Iran

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