Hepatitis C Virus Risk Factors in the Turkish Community

Yıldırım, Beytullah; Tahan, Veysel; Özaras, Reşat; Aytekin, Hüseyin; Mert, Ali; Tabak, Fehmı; Şentürk, Hakan

doi:10.1007/s10620-005-3061-3

Cited by 17 publications

(18 citation statements)

References 21 publications

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“…These findings were similar to other study which detected a high prevalence of (22.4%) anti-HCV seropositivity following dental surgery [23]. Similar studies conducted in Pakistan, Turkey, Morocco, and Italy had reported that dental procedure was one of the major risk factor for HCV transmission [1,4,11,24]. Moreover Ali et al, (2011) indicated that dental procedure is one of the major source of exposure for HCV transmission (39.7%) followed by injections (16.6%) and surgical procedures (16.6%) [24].…”

Section: Discussionsupporting

confidence: 91%

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Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Al-Kubaisy¹,

Al-Naggar²,

Ibrahim³

et al. 2014

Oral Biol Dent

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Background: The medical risk factor associated with hepatitis C virus (HCV) infection such as blood transfusion and surgery had been intensely studied in many countries. Up to 40% of patients infected with HCV may have non identifiable routes of viral acquisition. Dental extraction may be one of these risk factors. The purpose of the present study was to determine the existence of infection and the predominated HCV genotype among subjects with dental extraction. Material and methods: A case-control study involving pregnant women with and without history of dental extraction (n=776, n=2715, respectively). HCV antibodies (anti-HCV) were tested using subsequently third generation enzyme immunoassay (EIA-3) and immunoblot assay (Lia Tek-111). In addition 94 serum samples were subjected to molecular analysis using RT-PCR and DNA enzyme immunoassay (DEIA) method for HCV-RNA and genotypes. Results: Anti-HCV seroprevelance was significantly higher (6.3%) among cases with dental extraction (cases) than their counter control group (control) (2.63%) (p=0.00001). Dental extraction act as a risk factor for HCV infection (OR=2.73; 95% CI=1.8-3.9). HCV-RNA was found to be significantly higher (74.6%) in cases than (38.7%) control group (p=0.0016). No significant association between HCV genotypic and the history of tooth extraction but HCV-1b showed higher rate (90%) among dental extraction cases. Conclusion: Our study showed that dental extraction acts as a risk factor for acquiring HCV. Complete sterilization and cleaning of equipment is necessary.

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Section: Discussionsupporting

confidence: 91%

“…Probabilities due to sexual and interfamilial transmission are somehow low. In addition, tattoo may also consider as suspected factors in the transmission [4]. Transmission of HCV has been mainly related to intravenous drug use since blood products transmission has decreased in most developed countries [5].…”

Section: Introductionmentioning

confidence: 99%

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Al-Kubaisy¹,

Al-Naggar²,

Ibrahim³

et al. 2014

Oral Biol Dent

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“…5 In stu di es from Tur key, the rate of IV drug abu se as a risk factor for HCV trans mis si on was very low. 6,7 In vi ew of all the se facts, this ca se con trol study was de sig ned to de ter mi ne the risk fac tors of he pa ti tis C in fec ti on in To kat, a pro vin ce lo ca ted in the middle-in te ri or Black Se a Re gi on of Tur key.…”

mentioning

confidence: 99%

“…Yil di rim et al 6 com pa red 151 HCV po si ti ve pa ti ents who app li ed to Is tan bul Uni ver sity, Cerrah pa sa Fa culty of Me di ci ne Hos pi tal with the control gro up in terms of risk fac tors. In that study, it was de ter mi ned that the fol lo wing risk fac tors were ob ser ved sig ni fi cantly mo re com mon than the con trol gro up: sur gery, fre qu ent den tal ca re, den tal ex trac ti on, blo od tran fu si ons, mul tip le-part ners and se xu al in ter co ur se.…”

mentioning

confidence: 99%

“…In that study, in ac cor dan ce with our study, den tal ca re was found as an im por tant risk fac tor. Be si des, Yil di rim et al, 6 in ves ti ga ted ot her risk fac tors such as circum ci si on, ta to ing, acu punc tu re, sha ring to othbrus hes and ra zor bla des, IV drug abu se and having a proffession as a he alt hca re wor ker. It was ob served that the rates of the se fac tors we re not hig her than that of the con trol gro up.…”

mentioning

confidence: 99%

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Healthcare Related Risk Factors Account for the Majority of HCV Transmissions in Middle Black Sea Region of Turkey: A Case-Control Study

Barut¹,

Barut²,

Eğri³

2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : This ca se-con trol study was de sig ned to de ter mi ne the risk fac tors for hepa ti tis C vi rus trans mis si ons in Midd le Black Se a Re gi on of Tur key. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : One hun dred and ni nety-thre e an ti-HCV po si ti ve pa ti ents we re eli gib le for the study and the number of pa ti ents in con trol gro up was 190. The in di vi du als in each gro up we re qu es ti o ned for the fac tors ha ving a pos sib le ro le in trans mis si on of he pa ti tis C vi rus. The da ta was eva lu a ted sta tisti cally by Chi-squ a re and lo gis tic reg res si on analy sis. R Re e s su ul lt ts s: : Among ca ses, 78% of pa ti ents were fe ma les. The re was no sig ni fi cant dif fe ren ce in terms of gen der and ave ra ge ages bet we en two groups. Ta king sur gery, en dos copy, co ro nary an gi og raphy, num ber of the preg nan ci es and de li ve ries in to con si de ra ti on, no sta tis ti cal dif fe ren ce was fo und bet we en the ca se and con trol gro ups. Ho we ver, lo gis tic reg res si on analy sis re ve a led that the fol lo wing risk fac tors we re re la ted to HCV in fec ti on: his tory of blo od trans fu si on be fo re ye ar 1996 (Odd's Ra ti o (OR)= 4.5), ute ri ne cu retta ge and/or de li very in a hos pi tal (OR= 2.4), hos pi ta li za ti on for mo re than one we ek (OR= 2.7) and pre vi o us den tal ca re (OR= 1.8). C Co on nc c l lu u s si i o on n: : Apart from blo od trans fu si ons, hos pi ta li za ti on and me di cal pro ce du res li ke den tal ca re, cu ret ta ge or de li very in a hos pi tal we re im por tant risk fac tors for he pa ti tis C in fec ti on in To kat re gi on. The se risk fac tors sho uld be eli mi na ted with effec ti ve ste ri li za ti on and di sin fec ti on stra te gi es in or der to pre vent the spre ad of HCV.K Ke ey y W Wo or rd ds s: : Hepatitis C; risk factors; transmission Ö ÖZ ZE ET T A Am ma aç ç: : Bu va ka-kon trol ça lış ma sı, Tür ki ye' nin Or ta Ka ra de niz Böl ge sin de ki he pa tit C virü sü bu laş la rı için risk fak tör le ri ni sap ta mak ama cıy la ta sar lan dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : An ti-HCV tes ti po zi tif olan 193 has ta ça lış ma için uy gun du ve kon trol gru bun da ki has ta sa yı sı 190'dı. Her grup ta ki bi rey ler, he pa tit C vi rü sü bu la şın da ola sı rol oy na ya bi le cek fak tör ler açı sın dan sorgu lan dı. Ve ri ler Ki-ka re ve lo jis tik reg res yon ana li zi ile is ta tis tik sel ola rak de ğer len di ril di. B Bu ul l --g gu u l la ar r: : Va ka ların %78'i ka dın dı. İki grup ara sın da, cin si yet da ğı lım la rı ve or ta la ma yaş lar ba kı mın dan an lam lı fark yok tu. Cer ra hi, en dos ko pi, ko ro ner an ji yog ra fi, ge be lik le rin ve doğum la rın sa yı sı dik ka te alın dı ğın da, va ka ve kon trol grup la rı ara sın da is ta tis tik sel fark sap tanma dı. Bu nun la bir lik te, lo jis tik reg res yon ana li zi aşa ğı da ki risk fak tör le ri nin HCV en fek si yo nu ile iliş ki li ol du ...

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Lymphoproliferative disorders in individuals with chronic hepatitis b and C in the Turkish population

İdilman¹,

Bozkuş²,

Seval³

et al. 2011

Journal of Medical Virology

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The aims of this cohort study were to evaluate the association of malignant lymphoproliferative disorders in patients with chronic viral hepatitis and to compare the results with those in individuals with non-alcoholic fatty liver disease. A total of 3,873 patients with chronic liver disease who were seen consecutively in the Liver Disease Outpatient Clinic between January 2001 and July 2007 were assessed retrospectively. The frequency of malignant lymphoproliferative disorders including non-Hodgkin's lymphoma, Hodgkin's lymphoma, and chronic lymphocytic leukemia in these patients was investigated. Of the total, 1,999 patients had chronic hepatitis B infection (male/female: 1,226/773, mean age: 45.1 ± 13.2 years), 978 had chronic hepatitis C infection (male/female: 437/541, mean age: 53.8 ± 13.7 years), and the remaining 896 had non-alcoholic fatty liver disease (male/female: 450/446, mean age: 50.8 ± 11.2 years). A malignant lymphoproliferative disorder was identified in 13 patients (male/female: 9/4, mean age: 52.8 ± 16.8 years) with chronic viral hepatitis, while no case of malignant lymphoproliferative disorder was identified in individuals with non-alcoholic fatty liver disease (P = 0.048). Among the patients with malignant lymphoproliferative disorders, seven had chronic hepatitis B infection and six had chronic hepatitis C infection; 11 had non-Hodgkin's lymphoma and two had chronic lymphocytic leukemia. All non-Hodgkin's lymphoma cases were B-cell lymphoma. Based on the data obtained in this investigation, the association with malignant lymphoproliferative disorders in chronic viral hepatitis seems to be high as compared to that occurring in individuals with non-alcoholic fatty liver disease.

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Hepatitis C Virus Risk Factors in the Turkish Community

Cited by 17 publications

References 21 publications

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Healthcare Related Risk Factors Account for the Majority of HCV Transmissions in Middle Black Sea Region of Turkey: A Case-Control Study

Lymphoproliferative disorders in individuals with chronic hepatitis b and C in the Turkish population

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