Hepatitis C virus infection and risk of gallstones: A meta-analysis

Wijarnpreecha, Karn; Panjawatanan, Panadeekarn; Lekuthai, Natasorn; Ungprasert, Patompong

doi:10.1111/jebm.12277

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…In the present study, patients with CHC infection had a higher prevalence of GD than did chronic HBV (CHB)-infected patients. This finding is in agreement with that of previous studies 11 , 12 . Stroffolini et al .…”

Section: Discussionsupporting

confidence: 94%

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Hepatitis C Virus Infection Increases Risk of Gallstone Disease in Elderly Chinese Patients with Chronic Liver Disease

Gao

2018

Sci Rep

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We investigated possible links between the etiology of liver disease and gallstone risk in Chinese patients with chronic liver disease (CLD). We compared the outcomes of 267 Chinese CLD patients with gallstones and those of a control group of 1,015 CLD patients without gallstones. Logistic regression analyses adjusting for demographic features and other gallstone risk factors revealed that liver cirrhosis increased the risk of gallstone development twofold [adjusted odds ratio (AOR); 95% confidence interval (95% CI): 2.343 (1.710–3.211)]. HCV infection increased gallstone risk 1–2-fold [AOR; 95% CI: 1.582 (1.066–2.347)] higher than did HBV infection. Multivariate analyses of the risk of developing gallstones in patients with liver cirrhosis after an HCV or HBV infection yielded an estimated AOR (95% CI) of 1.601 (1.063–2.413) in patients with an HCV infection. In elderly patients with CLD (≥60 years of age), gallstone risk also increased significantly after an HCV infection [AOR (95% CI): 2.394 (1.066–5.375)]. HCV infection, older age, and liver cirrhosis significantly correlate with an increased risk of gallstone development in Chinese patients with CLD. HCV infection further increases this risk in both patients with liver cirrhosis and in elderly CLD patients (≥60 years of age).

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Section: Discussionsupporting

confidence: 94%

“…Wijarnpreecha et al . 12 conducted a meta-analysis to assess the risk of gallstone development in HCV-infected patients; these authors found that such patients had a significantly increased risk of developing gallstones compared to those without an HCV infection.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C Virus Infection Increases Risk of Gallstone Disease in Elderly Chinese Patients with Chronic Liver Disease

Gao

2018

Sci Rep

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“…Conversely, there have been observational association of increased gallbladder disease in patient with hepatitis C infection including cholelithiasis thought mainly because of secondary metabolic activity rather than the effect of therapeutic treatment. 10 Similarly, hepatitis B rather than hepatitis C infection has been observed to be associated with gallbladder polyps in targeted population. 11 In our case, despite the patient had previous hepatitis C infection which was adequately treated, the fact that Schistosoma egg was isolated from the polyp, cements being the underlying causative pathology.…”

Section: Discussionmentioning

confidence: 99%

“…Trying to explore associative previous hepatitis C infection, the natural history of the disease is well‐established as being primarily hepatotropic leading to predominantly chronic liver disease including liver cirrhosis. Conversely, there have been observational association of increased gallbladder disease in patient with hepatitis C infection including cholelithiasis thought mainly because of secondary metabolic activity rather than the effect of therapeutic treatment 10 . Similarly, hepatitis B rather than hepatitis C infection has been observed to be associated with gallbladder polyps in targeted population 11 .…”

Section: Discussionmentioning

confidence: 99%

Schistosoma gallbladder polyp masquerading as a neoplasm: Rare case report and literature review

Ali

Goravey

Al‐Bozom

et al. 2021

Clinical Case Reports

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“…These findings were compatible with those of previous studies that revealed negligible or decreased risk of HCC in patients with prior acute cholecystitis. 15,28 Gallstones and HCC share risk factors, such as CHB, 34 CHC, 35 CLD, 36,37 LC, 38 and DM. 39 Therefore, increased cumulative incidence and crude risk of HCC in patients with gallstones are related not by the presence of gallstones but by shared risk factors.…”

Section: Discussionmentioning

confidence: 99%

Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma

Ahn

Kim

Kang

et al. 2022

J of Gastro and Hepatol

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Background and Aim: Gallstones have been reported to be positively associated with hepatobiliary cancers. However, risks of these cancers by cholecystectomy or in patients with complicated gallstones are controversial. We studied the effect of cholecystectomy on the risk of cholangiocarcinoma (CCA) or hepatocellular carcinoma (HCC) in patients with gallstones and subgroup of complicated gallstones. Methods: Patients with gallstone disease (n = 958 677) and age-matched and sex-matched controls (n = 9 586 770) were identified using the Korean National Health Insurance database. Complicated gallstones were defined as gallstones associated with acute cholecystitis or acute cholangitis. Adjusted hazard ratios (adjusted hazard ratios, 95% confidence interval) of CCA and HCC incidences were evaluated in patients with gallstones who received cholecystectomy compared to the controls. We also analyzed these effects in patients with complicated gallstones. Results: Patients with gallstones showed increased risks of CCA (1.80, 1.67-1.93) and HCC (1.03, 1.00-1.07) compared with controls. Cholecystectomy had minimal effects on the risks of CCA (1.94, 1.76-2.14) and HCC (0.93, 0.87-0.99) compared with those without cholecystectomy. However, patients with complicated gallstones showed highly increased CCA risk (5.62, 4.89-6.46) and a 30% risk reduction after cholecystectomy (3.91, 3.43-4.46). Risk reduction by cholecystectomy was greater for extrahepatic CCA than for intrahepatic CCA or ampulla of Vater cancer. However, the risk of HCC was not different in patients with complicated gallstones and those who underwent cholecystectomy compared to controls. Conclusion:The risk of CCA was markedly increased in patients with complicated gallstones and was partially reduced by cholecystectomy. The risk change of HCC was minimal with gallstones or cholecystectomy.

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Hepatitis C virus infection and risk of gallstones: A meta-analysis

Abstract: Our study demonstrated a significantly increased risk of gallstones among HCV-infected patients. Further studies are required to clarify how this risk should be addressed in the clinical picture.

Cited by 8 publications

References 33 publications

Hepatitis C Virus Infection Increases Risk of Gallstone Disease in Elderly Chinese Patients with Chronic Liver Disease

Hepatitis C Virus Infection Increases Risk of Gallstone Disease in Elderly Chinese Patients with Chronic Liver Disease

Schistosoma gallbladder polyp masquerading as a neoplasm: Rare case report and literature review

Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma

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