Hepatitis C prevalence and risk factors in hemodialysis patients in Central Brazil: a survey by polymerase chain reaction and serological methods

Carneiro, Megmar Aparecida dos Santos; Martins, Regina Maria Bringel; Teles, Sheila Araújo; Silva, Simonne A.; Lopes, Carmen Luci Rodrigues; Cardoso, Divina D. P.; Vanderborght, Bart; Yoshida, Clara Fumiko Tachibana

doi:10.1590/s0074-02762001000600003

Cited by 63 publications

(87 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our country, HCV prevalence rates of 20.3%, 23.8%, 33.4% and 39% were recently found in Santa Catarina (Moraes 2001), Bahia (Santana et al 2001), Minas Gerais (Busek et al 2002), and Goiás (Carneiro et al 2001), respectively.…”

mentioning

confidence: 61%

“…Recent data from Indonesia, Syria, and Jordan revealed rates of 63.4%, 48.9% and 34.6%, respectively (Othman & Monem 2001, Bdour 2002, Chanpong et al 2002. In Brazil, anti-HCV prevalence ranges from 20.3% to 64.7% (Vanderborght et al 1995, Carneiro et al 2001, Santana et al 2001, Busek et al 2002. Thus, the prevalence of 13% found in hemodialysis patients in Tocantins could be placed in a low position.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

[No Title Available]

Souza

Luz²,

Teles

et al. 2003

Mem. Inst. Oswaldo Cruz

Self Cite

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 61%

Section: Discussionmentioning

confidence: 98%

[No Title Available]

Souza

Luz²,

Teles

et al. 2003

Mem. Inst. Oswaldo Cruz

Self Cite

View full text Add to dashboard Cite

show abstract

“…Several projects performed in Brazil between 1992 and 2004 point a HCV frequency varying from 23.5% to 65% [7,[12][13][14][15][16]. Data from Santa Catarina State indicate the occurrence of the infection by HCV at the dialysis clinics in 33.4% [17].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C risk factor for patients submitted to dialysis

Baldessar¹,

Bettiol²,

Foppa³

et al. 2007

Braz J Infect Dis

View full text Add to dashboard Cite

This article reports the results of the research which has evaluated the prevalence and factors associated to the presence of Hepatitis C in patients submitted to dialysis at the Clinica de Doenças Renais (Clinic of Renal Diseases) in Tubarao city (CRDT), Santa Catarina State, Brazil, in the period between January 1 st , 2004 to December 31 st in the same year. The prevalence of 16.8% of Hepatitis C in the studied population and the time-length of dialysis as significative risk factor have become evident. The non-correlation of seropositivity of the followings factors is also indicated: age, gender, base diseases, infrastructures, the type of clinic machines, the type of dialyser, used membranes, the machine sterilisation and substances for this process as well as the number of times of the dialyser reutilization. The data represented in this project suggest that the Hepatitis C presents high prevalence in patients in dialysis and the time-length of the treatment is a risky factor to acquire the infection.

show abstract

“…Prevalence is lower in populations highly selected by previous screening for risk factors associated with the infection, such as blood donors, and is higher among groups highly exposed to parenteral transmission of the virus, such as intravenous drug users or hemodialysis patients 2,13,21,29 . In Brazil, available data usually refer to large centers 8,12,22 .…”

Section: Introductionmentioning

confidence: 99%

Serological, epidemiological and molecular aspects of hepatitis C virus infection in a population from Londrina, PR, Brazil, 2001-2002

Vogler

Nishiya

Morimoto

et al. 2004

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYSerological, epidemiological and molecular aspects of hepatitis C virus (HCV) infection were evaluated in 183 subjects from Londrina, Paraná, Brazil, and adjacent areas. Serum samples which tested anti-HCV positive by microparticle enzyme immunoassay (MEIA) obtained from eight patients with chronic hepatitis C, 48 blood donors, and 127 patients infected with the human immunodeficiency virus (HIV) were submitted to another enzyme immunoassay (ELISA) and to the polymerase chain reaction (PCR). About 78.7% of samples were also reactive by ELISA, with the greater proportion (70.8%) of discordant results verified among blood donors. A similar finding was observed for HCV-RNA detection by PCR, with 111/165 (67.3%) positive samples, with higher rates among HIV-positive subjects and patients with chronic hepatitis than among blood donors. Sixty-one PCRpositive samples were submitted to HCV genotyping, with 77.1, 21.3 and 1.6% of the samples identified as types 1, 3 and 2, respectively. Finally, analysis of some risk factors associated with HCV infection showed that intravenous drug use was the most common risk factor among HIV/HCV co-infected patients, while blood transfusion was the most important risk factor in the group without HIV infection. The present study contributed to the knowledge regarding risk factors associated with HCV infection and the distribution of HCV genotypes in the population evaluated. KEYWORDS:Hepatitis C virus; Anti-HCV; Genotypes; Epidemiology. INTRODUCTIONAbout 170 million people all over the world are infected with hepatitis C virus (HCV), although many ignore such fact 30 . In most cases, the infection develops as an asymptomatic clinical picture but with severe consequences, since about 80% of the infected subjects develop chronic hepatitis, cirrhosis or hepatocellular carcinoma 16,28 .Co-infection of HCV-infected subjects with the human immunodeficiency virus (HIV) has important implications for the prognosis and management of both diseases. These subjects show elevated alanine aminotransferase levels and are at a higher risk of developing fibrosis, cirrhosis, liver failure or hepatocellular carcinoma than subjects infected only with HCV 6 ; in addition, they show a higher risk of developing hepatic toxicity related to the use of highly active antiretroviral therapy than patients infected only with HIV 5,26 .The use of the polymerase chain reaction (PCR) for the detection of HCV-RNA allows the identification of the presence of active HCV infection. However, RNA levels may show fluctuations with nondetectable periods even in patients not submitted to interferon therapy 7 .Patient counseling regarding the risk-benefit of treatment also requires analysis of a liver biopsy and the determination of the HCV genotype. Differences in the response to treatment depending on the HCV genotype have been observed, with type 1 being more resistant than types 2 and 3 19 . Genotyping based on the amplification of the 5' untranslated region (5'-UTR) has the advantage that it can be performed on PCR ...

show abstract

Hepatitis C prevalence and risk factors in hemodialysis patients in Central Brazil: a survey by polymerase chain reaction and serological methods

Abstract: An hemodialysis population in Central Brazil was screened by polymerase chain reaction (PCR) and serological methods to assess the prevalence of hepatitis C virus (HCV) infection

Cited by 63 publications

References 20 publications

[No Title Available]

[No Title Available]

Hepatitis C risk factor for patients submitted to dialysis

Serological, epidemiological and molecular aspects of hepatitis C virus infection in a population from Londrina, PR, Brazil, 2001-2002

Contact Info

Product

Resources

About