Hepatitis C–Associated Keratitis

Chronic hepatitis C virus infection is not associated with Mooren's ulcer

“…25 An association between HCV and Mooren's ulcer was first suggested in 1993 6 and five cases of Mooren's ulcer coexistent with chronic HCV infection were reported. [6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid.…”

“…[6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid. 26 These observations led to the speculation that chronic HCV infection may have an important role in the pathogenesis of Mooren's ulcer.…”

Chronic hepatitis C virus infection is not associated with Mooren's ulcer

“…25 An association between HCV and Mooren's ulcer was first suggested in 1993 6 and five cases of Mooren's ulcer coexistent with chronic HCV infection were reported. [6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid.…”

“…[6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid. 26 These observations led to the speculation that chronic HCV infection may have an important role in the pathogenesis of Mooren's ulcer.…”

Hepatitis C virus-associated keratitis

“…27 Interferon alpha-2b caused at least temporary remission of eye disease in two previously reported series. 7,8 Genetic susceptibility may explain why the condition is seen in some patients and not others. There can be multiple causes of Mooren's ulcers, and some of them may not be associated in any way with any underlying systemic viral illness.…”

Ocular changes due to systemic alpha-interferon therapy for hepatitis C

“…The common sense for most authors is that careful monitoring should be performed in the presence of any ocular sign, even without symptoms (3,(12)(13)(14)16,(19)(20)27,29) . The ophthalmic intervention is of crucial importance in order to keep satisfactory ocular function, even if invasive procedures are necessary, such as laser retinal photocoagulation or eye surgery (8,25) .…”

Chronic hepatitis C virus infection is not associated with Mooren's ulcer

“…25 An association between HCV and Mooren's ulcer was first suggested in 1993 6 and five cases of Mooren's ulcer coexistent with chronic HCV infection were reported. [6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid.…”

“…[6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid. 26 These observations led to the speculation that chronic HCV infection may have an important role in the pathogenesis of Mooren's ulcer.…”

Hepatitis C virus-associated keratitis

“…27 Interferon alpha-2b caused at least temporary remission of eye disease in two previously reported series. 7,8 Genetic susceptibility may explain why the condition is seen in some patients and not others. There can be multiple causes of Mooren's ulcers, and some of them may not be associated in any way with any underlying systemic viral illness.…”

Ocular changes due to systemic alpha-interferon therapy for hepatitis C

“…The common sense for most authors is that careful monitoring should be performed in the presence of any ocular sign, even without symptoms (3,(12)(13)(14)16,(19)(20)27,29) . The ophthalmic intervention is of crucial importance in order to keep satisfactory ocular function, even if invasive procedures are necessary, such as laser retinal photocoagulation or eye surgery (8,25) .…”

Chronic hepatitis C virus infection is not associated with Mooren's ulcer

“…25 An association between HCV and Mooren's ulcer was first suggested in 1993 6 and five cases of Mooren's ulcer coexistent with chronic HCV infection were reported. [6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid.…”

“…[6][7][8][9] In three of these cases the anti-HCV therapy, interferon, was used successfully to treat the Mooren's ulcer. [7][8][9] Subsequently, it was reported that a patient with Mooren's ulcer and chronic HCV infection showed symptomatic improvement and alleviation of corneal ulceration when treated with a systemic steroid. 26 These observations led to the speculation that chronic HCV infection may have an important role in the pathogenesis of Mooren's ulcer.…”

Hepatitis C virus-associated keratitis

“…27 Interferon alpha-2b caused at least temporary remission of eye disease in two previously reported series. 7,8 Genetic susceptibility may explain why the condition is seen in some patients and not others. There can be multiple causes of Mooren's ulcers, and some of them may not be associated in any way with any underlying systemic viral illness.…”

Ocular changes due to systemic alpha-interferon therapy for hepatitis C

“…The common sense for most authors is that careful monitoring should be performed in the presence of any ocular sign, even without symptoms (3,(12)(13)(14)16,(19)(20)27,29) . The ophthalmic intervention is of crucial importance in order to keep satisfactory ocular function, even if invasive procedures are necessary, such as laser retinal photocoagulation or eye surgery (8,25) .…”