Hepatitis C and Arthritis: An Update

Sanzone, Aja; Bégué, Rodolfo E.

doi:10.1016/j.idc.2006.09.010

Cited by 9 publications

(21 citation statements)

References 57 publications

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“…The impact of arthritic conditions is expected to grow as the elderly population increases in the coming decades [39, 40]. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common categories of arthritis [8, 41–43].…”

Section: Biological Functions Of Adamts-12mentioning

confidence: 99%

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

Wei

Richbourgh

Jia

et al. 2014

Mediators of Inflammation

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ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.

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Section: Biological Functions Of Adamts-12mentioning

confidence: 99%

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

Wei

Richbourgh

Jia

et al. 2014

Mediators of Inflammation

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“…The mechanism of pathogenesis of diabetes in patients with HCV infection remains unclear though it has been implicated that insulin resistance plays an important role and is related to fibrosis score [12].…”

Section: Introductionmentioning

confidence: 99%

Association of Hepatitis C Virus Infection and Type 2 Diabetes in Egypt: A Hospital-Based Study

Abdelaziz

Galal

Sedrak

et al. 2016

JDM

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Background: The relation between hepatitis C virus (HCV) infection and the development of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to investigate the presence of an association between T2DM and HCV. Methods: A case control study was conducted at the outpatients' clinics of Kasr El-Aini Hospital (KAH), from October 2013 till March 2014. In this study, 389 HCV patients were selected as cases and 389 healthy controls were also included. Demographic and clinical data were collected using a structured questionnaire. Laboratory investigations including liver function tests (LFT), blood glucose level and radioimmunoblot assay (ELISA) were performed. Results: Out of 389 HCV cases, 219 (56.3%) were diabetic, whereas 145 (37.3%) were diabetic among the healthy controls. Occurrence of diabetes among cirrhotic patients was 1.7 times higher than non-cirrhotic. Logistic regression showed that residence (P < 0.001, OR = 2.7), occupation (P = 0.03, OR = 1.8), and smoking (P = 0.04, OR = 2) were the predictive factors for occurrence of T2DM in HCV patients. Conclusions: In this study, we found a positive association between HCV infection and T2DM. Residence, occupation and smoking were the predictive factors for the association of T2DM in HCV patients, whereas hypertension and BMI were only adjunctive factors.

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“…Extrahepatic (EH) manifestations associated with HCV infection include endocrinological manifestations such as diabetes mellitus (DM) [6] and thyroiditis [7], rheumatologic manifestations such as arthralgias, arthritis [8] and mixed cryoglobulinemia [9]. The prevalence of clinically significant EH manifestations is relatively low, but can be associated with significant morbidity and even mortality.…”

Section: Introductionmentioning

confidence: 99%

Association of HCV with diabetes mellitus: an Egyptian case-control study

Elhawary

Mahmoud

El-Daly

et al. 2011

Virol J

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BackgroundThe highest Hepatitis C Virus (HCV) prevalence in the world occurs in Egypt. Several studies from different parts of the world have found that 13% to 33% of patients with chronic HCV have associated diabetes, mostly type II Diabetes Mellitus (DM). In Egypt the prevalence of DM is 25.4% among HCV patients. Therefore, it is important to identify the magnitude of the problem of diabetes in order to optimize the treatment of chronic hepatitis C.MethodsThe objective of this case-control study was to evaluate the prevalence of DM and other extrahepatic (EH) manifestations among patients with different HCV morbidity stages including asymptomatic, chronic hepatic and cirrhotic patients. In this study, 289 HCV patients older than 18 were selected as cases. Also, 289 healthy controls were included. Laboratory investigations including Liver Function tests (LFT) and blood glucose level were done. Also serological assays including cryoglobulin profile, rheumatoid factor, antinuclear antibody, HCV-PCR were performed.ResultsOut of 289 HCV cases, 40 (13.84%) were diabetic. Out of 289 healthy controls, 12 (4.15%) were diabetic. It was found that the diabetic HCV group mean age was [48.1 (± 9.2)]. Males and urbanians represented 72.5% and 85% respectively. Lower level of education was manifested in 52.5% and 87.5% were married. In the nondiabetic HCV group mean age was [40.7 (± 10.4)]. Males and urbanians represented 71.5% and 655% respectively. secondary and higher level of education was attained in 55.4% and 76.7% were married. Comparing between the diabetic HCV group and the non diabetic HCV group, age, residence and alcohol drinking were the only significant factors affecting the incidence of diabetes between the two groups. There was no significant difference regarding sonar findings although cirrhosis was more prevalent among diabetic HCV cases and the fibrosis score was higher in diabetic HCV patients than among the non diabetic HCV cases.ConclusionThe diabetic patients in the HCV group were older, more likely to have a history of alcohol drinking than the non diabetic HCV cases. Age and alcohol drinking are factors that could potentially contribute to the development of type 2 diabetes. Logistic regression analyses showed that age and residence in urban regions were the predictive variables that could be associated with the presence of diabetes. Alcohol consumption was not a significant predictive factor.

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Hepatitis C and Arthritis: An Update

Cited by 9 publications

References 57 publications

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

ADAMTS-12: A Multifaced Metalloproteinase in Arthritis and Inflammation

Association of Hepatitis C Virus Infection and Type 2 Diabetes in Egypt: A Hospital-Based Study

Association of HCV with diabetes mellitus: an Egyptian case-control study

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