Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: A prospective cohort study

Liu, Tong; Song, Chunhua; Zhang, Youcheng; Siyin, Sarah Tan; Zhang, Qi; Song, Mengmeng; Cao, Lei; Shi, Hanping

doi:10.1002/ijc.33891

Cited by 36 publications

(50 citation statements)

References 46 publications

(92 reference statements)

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“…Data was taken from the Kailuan cohort study, which was designed to explore the risk factors for common chronic diseases. The detailed study design and procedures were described previously 17 . All 155 418 Kailuan Corporation employees (including retirees) were invited to participate in baseline physical examinations at Kailuan General Hospital and its 10 affiliated institutions between July 2006 and October 2007.…”

Section: Methodsmentioning

confidence: 99%

C‐reactive protein trajectories and the risk of all cancer types: A prospective cohort study

Liu

Zhang

Song

et al. 2022

Intl Journal of Cancer

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A single CRP measurement is insufficient to examine the association of long-term patterns of CRP concentration with cancer risk. We prospectively examined the relationship between CRP trajectory patterns and new-onset cancers among 52 276 participants. Latent mixture modeling was used to identify CRP trajectories. Cox proportional hazards regression models were used to evaluate the association between CRP trajectory patterns and the risk of overall and specific-site cancer. Four CRP trajectories patterns were identified: low-stable pattern (n = 43 258), moderateincreasing pattern (n = 2591), increasing-decreasing pattern (n = 2068) and elevated-decreasing pattern (n = 4359). Relative to the low-stable pattern, the moderate-increasing trajectory pattern was associated with an elevated risk of overall, lung, breast, leukemia, bladder, stomach, colorectal, liver, gallbladder or extrahepatic bile duct cancer and leukemia. Participants in the increasing-decreasing trajectory pattern were associated with an elevated risk of overall, lung, breast, bladder, pancreatic and liver cancer. The increasing-decreasing trajectory pattern was also associated with decreased risk of colorectal cancer in the multivariate analyses. Elevated-decreasing trajectory pattern was associated with increased risk of leukemia and decreased risk of esophageal and colorectal cancer. CRP trajectories play an important role in the occurrence of cancers, especially in the lung, breast, bladder, stomach, colorectal, liver, gallbladder and extrahepatic bile duct cancer and leukemia.

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Section: Methodsmentioning

confidence: 99%

C‐reactive protein trajectories and the risk of all cancer types: A prospective cohort study

Liu

Zhang

Song

et al. 2022

Intl Journal of Cancer

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“…The Kailuan study explored risk factors for chronic diseases including cancer. The study’s design and procedures were previously described [ 15 ]. In all, a total of 101,510 Kailuan Group employees (81,110 males and 20,400 women, ages 18 to 98) were invited to participate in the baseline health assessment between July 2006 and October 2007, and biennial follow-ups.…”

Section: Methodsmentioning

confidence: 99%

The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer

et al. 2022

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Background Inflammation and metabolic syndrome (MetS) may act synergistically and possibly accelerate the initiation and progression of colorectal cancer (CRC). We prospectively examined the joint effect of MetS and inflammation on the risk of CRC. Methods We studied 92,770 individuals from the Kailuan study. MetS was defined based on the presence of three or more of the following components. (1) high glucose: FPG > 5.6 mmol/L; (2) high blood pressure: SBP ≥ 130 mmHg or DBP ≥ 85 mmHg; (3) high triglycerides: triglycerides > 1.69 mmol/L; (4) low HDL-C: HDL-C < 1.04 mmol/L in men or 1.29 mmol/L in women; and (5) visceral adiposity: waist circumference ≥ 85 cm in men or 80 cm in women. Inflammation was defined as hs-CRP ≥ 3 mg/L. We divided participants into four groups for the primary exposure according to the presence/absence of inflammation and presence/absence of MetS. Cox proportional hazards regression models were used to evaluate the association of MetS and/or inflammation with the risk of CRC. Results Compared with metabolically healthy noninflammatory individuals, inflammatory participants without MetS and inflammatory participants with MetS were associated with a 1.3-fold and 4.18-fold increased risk of CRC with corresponding HRs (95% CI) of 1.34 (1.09, 1.64) and 4.18 (3.11, 5.62), respectively. The combination of MetS and inflammation was associated with the highest risk of CRC in all subgroups, especially among participants who were female, in younger age, and obese. Sensitivity analyses further validated our primary findings. Conclusions We found the combination of MetS and inflammation could significantly increase the risk of CRC. Including CRP in the diagnosis of MetS may help to identify additional high-risk participants who should be targeted for early diagnosis and prevention of CRC. Trial registration Kailuan study, ChiCTR–TNRC–11001489. Registered 24 August, 2011-Retrospectively registered, http:// www.chictr.org.cn/showprojen.aspx?proj=8050

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“…As described previously ( 14 ), the Kailuan Study is a prospective, population-based cohort study conducted in the Kailuan community in Tangshan, China. 101,510 employees or retired workers (81,110 men and 20,400 women, aged 18-98 years) in the Kailuan Company participated in the first health examination between July 2006 and October 2007 and biennial follow-ups.…”

Section: Methodsmentioning

confidence: 99%

High salt intake combined with hypertension elevated the risk of primary liver cancer: a prospective cohort study

Liu

Zhang²,

Xiao³

et al. 2022

Front. Oncol.

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BackgroundHypertension and high-salt intake may act synergistically to increase the risk of primary liver cancer (PLC). We prospectively examined the joint effect of hypertension and salt intake on the risk of PLC incidence.MethodsA total of 92,978 participants were included in the final analyses. The study population was divided into 4 groups according to the presence or absence of hypertension and salt intake. Cox proportional hazards regression models were used to evaluate the association of hypertension and/or high-salt intake with the risk of incident cancers. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring a median follow-up of 12.69 years, a total of 418 incident cancer cases were identified. Hypertension was a risk factor for PLC in women but not in men. High salt intake was associated with an elevated risk of PLC in men. A significant interaction between salt intake and hypertension was found for the risk of PLC (P for interaction=0.045). Compared with Group 1 (hypertension-, high salt intake-), participants in Group 2 (hypertension-, high salt intake+) and Group 4 (hypertension+, high salt intake+) were associated with an elevated risk of PLC with the corresponding multivariate HRs (95%CIs) of 1.73(0.96,3.10) and 1.96(1.09,3.53) respectively. No significant mediation effect was found for the association between hypertension, salt intake and PLC risk.ConclusionsThe combination of high salt intake and hypertension could significantly increase the risk of PLC. It may be reasonable to recommend a low-salt intake to prevent and control the prevalence of PLC and hypertension.Trial registrationKailuan study, ChiCTR–TNRC–11001489. Registered 24 August, 2011-Retrospectively registered, https://www.chictr.org.cn/showprojen.aspx?proj=8050

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Hepatitis B virus infection and the risk of gastrointestinal cancers among Chinese population: A prospective cohort study

Cited by 36 publications

References 46 publications

C‐reactive protein trajectories and the risk of all cancer types: A prospective cohort study

C‐reactive protein trajectories and the risk of all cancer types: A prospective cohort study

The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer

High salt intake combined with hypertension elevated the risk of primary liver cancer: a prospective cohort study

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