Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis

Wang, Zheng; Sheng, Yuan‐Yuan; Dong, Qiongzhu; Qin, Lun–Xiu

doi:10.3748/wjg.v22.i10.3038

Cited by 32 publications

(39 citation statements)

References 35 publications

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“…Specifically, HBV-associated ICCs may have a higher AFP and CA 19-9 levels, tend to have tumour capsule formation, cirrhosis and a lower rate of lymph node metastasis. Two large meta-analyses have shown that HBV was associated with better prognosis, which is consistent with the majority of the studies included in this systematic review, but this association warrants further prospective investigation (44,45).…”

Section: Discussion Discussionsupporting

confidence: 86%

Hepatitis B virus-Associated Intrahepatic Cholangiocarcinoma Has Distinct Clinical, Pathological and Radiological Characteristics: A Systematic Review

Ng¹,

Khoo²,

Velaga³

et al. 2019

SGO

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Intrahepatic cholangiocarcinoma (ICC) is a rare hepatic malignancy with a poor prognosis. It is known that Hepatitis B is both a risk factor and a prognosis factor for ICC. However, little is known about the clinical, pathological and radiological characteristics of ICC patients with hepatitis B virus (HBV) infection. A systematic review of relevant literature was performed using PubMed and EMBASE databases. HBV-associated ICC revealed several unique and interesting features, it was found to have higher alpha-fetoprotein (AFP), cancer antigen 19-9 (CA 19-9) levels, capsule formation and cirrhosis, but associated with lower lymph node metastasis. Radiologically, it was shown that some of the HBV-associated ICC tend to mimic atypical radiological features of HCC. Pathologically, it was found that HBx protein gene expression was associated with HBV-associated ICC, and that hepatic progenitor cells may be an alternative origin for HBV-associated ICC. In conclusion, HBV-associated ICC has distinct clinical, pathological and radiological characteristics, but further research is needed to further understand the pathogenesis of the disease.

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Section: Discussion Discussionsupporting

confidence: 86%

Hepatitis B virus-Associated Intrahepatic Cholangiocarcinoma Has Distinct Clinical, Pathological and Radiological Characteristics: A Systematic Review

Ng¹,

Khoo²,

Velaga³

et al. 2019

SGO

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“…More recently, Tao et al [28] found that prothrombin time was also found to be higher in HBV-associated ICC patients (P = 0.030), complementing the studies from Zhou et al [42] and Peng et al [27]. The above mentioned clinicopathological characteristics of HBV-associated ICC were verified by a meta-analysis that involved 14 studies and 2842 cases [43]. HBV infection was more frequent in male patients [odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.06 to 3.44] and was correlated with elevated serum aspartate transaminase (AST) (OR = 1.93, 95%CI = 1.11 to 3.35) and AFP levels (OR = 3.86, 95%CI = 2.58 to 5.78), as well as a relatively lower level of serum CA19-9 (OR = 0.47, 95%CI = 0.34 to 0.65) [43].…”

Section: Clinicopathological Characteristicsmentioning

confidence: 76%

“…The above mentioned clinicopathological characteristics of HBV-associated ICC were verified by a meta-analysis that involved 14 studies and 2842 cases [43]. HBV infection was more frequent in male patients [odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.06 to 3.44] and was correlated with elevated serum aspartate transaminase (AST) (OR = 1.93, 95%CI = 1.11 to 3.35) and AFP levels (OR = 3.86, 95%CI = 2.58 to 5.78), as well as a relatively lower level of serum CA19-9 (OR = 0.47, 95%CI = 0.34 to 0.65) [43]. In addition, there were significant differences in the incidence of liver cirrhosis (OR = 6.44, 95%CI = 4.33 to 9.56), capsule formation (OR = 6.04, 95%CI = 3.56 to 10.26), and lymph node metastasis (OR = 0.39, 95%CI = 0.25 to 0.58).…”

Section: Clinicopathological Characteristicsmentioning

confidence: 99%

“…The majority of these studies insisted that HBV infection may be a favorable prognostic factor in patients with ICC [39, 40, 50–56]. However, there are still a few studies that reported HBV infection has no impact on the survival outcome of patients with ICC after hepatic resection [5, 31, 43, 57]. Zhang et al [50] suggested that ICC patients with both current and past HBV infection [seropositivity of HBsAg and hepatitis B core antibody (HBcAb)] had a significantly better prognosis than patients without a history of HBV infection and deduced that the activated immune responses by current or past HBV infection may enhance anti-tumor activity against ICC.…”

Section: Survival Outcomesmentioning

confidence: 99%

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Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma

et al. 2016

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It has been a decade since hepatitis B virus infection was identified as an etiological factor for the development of intrahepatic cholangiocarcinoma (ICC). In recent years, several studies have elucidated the critical impact of hepatitis B virus in ICC that significantly influenced the clinicopathological characteristics of ICC patients with intrahepatic cholangiocarcinoma. Distinctive features of patients with hepatitis B virus-associated ICC included younger age, preponderance of male patients, frequent elevation of alpha-fetoprotein, and infrequent lymph node metastasis. Furthermore, several studies indicated that the presence of hepatitis B virus is a favorable prognostic factor in terms of overall survival and relapse-free survival. However, there are also a few studies demonstrating that hepatitis B virus negatively influenced or showed no significant association with survival outcomes of patients with ICC. At present, there are no consensus on diagnostic procedures and treatments for such population. Therefore, we elucidated current knowledge and recent identifications of HBV-associated ICC to clarify the impact of chronic HBV infection on patients with ICC and to precisely conduct diagnostic procedures and curative treatments for HBV-associated ICC.

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“…Original studies that reported associations between HCV infection and hepatic and extrahepatic malignancies are summarized in Supporting Information Table 1. The strength of the evidence supporting associations between HCV infection and cancer is presented in Table and in previous meta‐analyses …”

Section: Associations Between Hcv Infection and Cancermentioning

confidence: 99%

The oncologic burden of hepatitis C virus infection: A clinical perspective

Torres

Shigle

Hammoudi

et al. 2017

CA A Cancer J Clinicians

110

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Chronic hepatitis C virus (HCV) infection affects millions of people worldwide and is associated with cancer. Direct-acting antivirals (DAAs) have changed HCV treatment paradigms, but little is known about management of HCV infection in patients with cancer. The substantial burden of HCV infection in patients with cancer and the inconclusive evidence regarding detection and management of HCV infection in patients with cancer prompted us to review the literature and formulate recommendations. Patients for whom HCV screening is recommended included all patients with hematological malignancies, hematopoietic cell transplant candidates or patients with hepatocellular carcinoma (HCC). There is lack of consensus-based recommendations for the identification of other cancer patients but physicians may consider screening patients belonging to groups at heightened risk of HCV infection including persons born during 1945–1965 and those at high risk for infection. Patients with evidence of HCV infection should be assessed by an expert to evaluate liver disease severity, comorbidities associated with HCV infection, and treatment opportunities. DAA therapy should be tailored on the basis of patient prognosis, type of cancer, cancer treatment plan, and hepatic and virologic parameters. HCV-infected cancer patients with cirrhosis (or even advanced fibrosis) and those at risk for liver disease progression, especially patients with HCV-associated comorbidities, should have ongoing follow-up, regardless of whether there is a sustained virologic response, to ensure timely detection and treatment of HCC. HCV infection and its treatment should not be considered contraindications to cancer treatment and should not delay the initiation of an urgent cancer therapy.

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Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis

Abstract: HBV infection may indicate a favorable prognosis in patients with intrahepatic cholangiocarcinoma, while HCV infection suggests a poor prognosis.

Cited by 32 publications

References 35 publications

Hepatitis B virus-Associated Intrahepatic Cholangiocarcinoma Has Distinct Clinical, Pathological and Radiological Characteristics: A Systematic Review

Hepatitis B virus-Associated Intrahepatic Cholangiocarcinoma Has Distinct Clinical, Pathological and Radiological Characteristics: A Systematic Review

Hepatitis B virus-associated intrahepatic cholangiocarcinoma: a malignancy of distinctive characteristics between hepatocellular carcinoma and intrahepatic cholangiocarcinoma

The oncologic burden of hepatitis C virus infection: A clinical perspective

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