Hepatitis B Vaccine Responsiveness in Connecticut Public Safety Personnel

Roome, Aaron; Walsh, Stephen J.; Cartter, Matthew L.; Hadler, James L.

doi:10.1001/jama.1993.03510240043029

Cited by 172 publications

(54 citation statements)

References 12 publications

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“…Due to this mandate, many previously unvaccinated adults received the HBV vaccination. Concern for low vaccine-induced anti-HBs titers grew after a study observed a high percentage of healthcare workers with non-protective (< 10 mIU/mL) post HBV-vaccination anti-HBs titers [35]. 11.0–11.5% of individuals with a BMI 25–35 kg/m2 had an inadequate response.…”

Section: Hepatitis B Virus (Hbv)mentioning

confidence: 99%

“…Data showed that 61.5% of severely obese subjects (BMI ≥ 35 kg/m2) had an inadequate response (≤ 10 mIU/mL), and 45% of severely obese individuals had no detectable anti-HBs titers (≤ 2 mIU/mL). This contrasts with a rate of only 4.3% of non-responders in healthy weight individuals (BMI < 25 kg/m2) [35]. Another study compared the two HBV vaccines, observing obesity as an independent risk factor (p< 0.01) for non-protective anti-HBs titers in Recombivax HB ™ -vaccinated health care workers in Minnesota [36].…”

Section: Hepatitis B Virus (Hbv)mentioning

confidence: 99%

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The weight of obesity on the human immune response to vaccination

Painter

Ovsyannikova

Poland

2015

Vaccine

165

130

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Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI) ≥ 30 kg/m2. The immune system is adversely affected by obesity, and these “immune consequences” raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected.

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Section: Hepatitis B Virus (Hbv)mentioning

confidence: 99%

Section: Hepatitis B Virus (Hbv)mentioning

confidence: 99%

The weight of obesity on the human immune response to vaccination

Painter

Ovsyannikova

Poland

2015

Vaccine

165

130

View full text Add to dashboard Cite

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“…Nearly 13.5 million (54%) Yemenite live below the poverty line and the majority of them (66–87%) live in rural areas [14, 15]. Factors associated with decreased immune response to HBV vaccine include increasing age, gender, obesity, nutritional status, smoking, and genetic factors [16, 17]. Poverty, socioeconomic status, lack of education, and weak health systems in rural areas in Yemen are interrelated factors that influence growth of children, which in turn affect their immune system [14] and response to vaccines.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Immunization to Hepatitis B Vaccine among Children under Five Years in Rural Areas of Taiz, Yemen

Alssamei

Al-Sonboli

Alkumaim³

et al. 2017

Hepatitis Research and Treatment

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Background. Hepatitis B virus (HBV) infection poses a major health problem worldwide. approximately 1 million deaths annually due to cirrhosis and hepatocellular carcinoma. Objectives. This study was conducted to determine the coverage rate of HBV vaccine and assess the vaccine protective response among children under five years old in rural areas of Yemen. Methods. A cross-sectional study was conducted from January to December 2015 in four districts of countryside Yemen. The target population was children aged from 6 to 59 months. 227 children were enrolled in the study. Questionnaire was used to collect of data. Serum samples were tested for anti-HBs antibodies by enzyme linked immunosorbent assay (ELISA). Anti-HBs level ≥ 10 IU/L was considered a protective response to the vaccine. Results. The coverage rate of HBV vaccine among children was 87.3%. A total of 143 (72.2%) children responded to the vaccine with anti-HBs level ≥ 10 IU/L, while 55 (27.8%) of the children had nonprotective anti-HBs levels of <10 IU/L (P = 0.003). Conclusion. This study revealed a good coverage rate of HBV vaccine in rural areas but the protective rate against HBV infection was moderate. A considerable proportion of vaccinated children should be considered for either revaccination or booster doses.

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“…Two previous studies on public safety personnel[5] or hospital staffs[6] have shown that higher body mass index (BMI) is a marker of poor response to hepatitis B vaccine. Two others have indicated that the gluteal injection of hepatitis B vaccine results in lower immunogenictity compare to deltoid injection, which is supposed to be related to the higher amount of fat tissue in gluteal region[7,8].…”

Section: Introductionmentioning

confidence: 99%

“…However, they aimed at evaluating the role of BMI beside many other risk factors (like cross-sectional studies) and not as a main factor (like case-control or cohort studies). Furthermore, they just examined multiple factors such as age, sex, BMI, and comorbidities[5,6]. Here, we have designed a control group with normal BMI to compare with obese and overweight cases.…”

Section: Introductionmentioning

confidence: 99%

Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases

Kabir

Pazouki

Jafari

et al. 2017

IBJ

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Background:There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases.Methods:In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. Cases were selected from a referral clinic for obesity and a referral hepatology clinic, both in Tehran, Iran.Results:Obese cases had lower percentage of liver diseases (66.9% vs. 100%, P<0.001) but higher percentage of hepatitis B vaccination history (74.9% vs. 51.2%, P<0.001). Median±inter-quartile range of anti-HBs titer in obese cases was significantly lower than controls (48.5±194.5 vs. 100±557.6, P=0.012).Conclusion:The level of anti-HBs surface antigen antibody’s titer in obese cases without liver disease is lower than control group. Therefore, a suitable strategy is needed to overcome this problem, which can be the use of longer needles for vaccination.

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Hepatitis B Vaccine Responsiveness in Connecticut Public Safety Personnel

Cited by 172 publications

References 12 publications

The weight of obesity on the human immune response to vaccination

The weight of obesity on the human immune response to vaccination

Assessment of Immunization to Hepatitis B Vaccine among Children under Five Years in Rural Areas of Taiz, Yemen

Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases

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