Hepatitis B, C, and D Virus Infection among Population Aged 10–64 Years in Mongolia: Baseline Survey Data of a Nationwide Cancer Cohort Study

Davaalkham, Dambadarjaa; Radnaa, Otgonbayar; Khuyag, Ser-Od; Shagdarsuren, Oyu-Erdene; Enkhbayar, Uranbaigali; Mukhtar, Yerkyebulan; Enkh-Oyun, Tsogzolbaatar; Nyam, Gunchmaa; Shaarii, Shatar; Singh, Pramil N.; Takahashi, Masaharu; Namdag, Bira; Okamoto, Hiroaki

doi:10.3390/vaccines10111928

Cited by 4 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Viral hepatitis is the major etiology of liver cirrhosis and HCC in Mongolia. 23,25 Moreover, HCC in Mongolia seems to have unique genomic characteristics and driver genes, such as SPTA1 , which is associated with HDV infection. 34,35 This suggests a close link between HDV infection and HCC in Mongolia.…”

Section: Discussionmentioning

confidence: 99%

“…17,[21][22][23] The seroprevalence rate of HBV and hepatitis C virus (HCV) infection in Mongolia were 10% and 15%, respectively, and the majority (75%-100%) of the HBV-infected subjects were also coinfected with HDV. 16,24,25 In contrast to HBV and HCV infection, for which potent antiviral therapy are available, only bulevirtide has been conditionally approved for the treatment of patients with compensated chronic hepatitis D in Europe as of 2020. 26,27 Elucidating the transmission routes of HDV infection and taking effective preventive strategies are key to reducing HDV infection in Mongolia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors associated with hepatitis D virus infection and preventive strategies in Mongolia

Su,

Ochirkhuree,

Namdag

et al. 2024

Journal of the Chinese Medical Association

Self Cite

View full text Add to dashboard Cite

Background: Hepatitis D virus (HDV) infection is highly prevalent in Mongolia. We aimed to identify the risk factors associated with HDV infection, propose preventive strategies, and evaluate the outcomes of a three-year collaborative project between Taiwan and Mongolia. Methods: In 2016 and 2018, we conducted onsite visits to Mongolia. Mongolian investigators collected questionnaires focusing on risk factors, demographic characteristics, and serum samples for acute HDV infections. Furthermore, 19 Mongolian seed teachers participated in a one-week workshop on infection control in Taiwan. Subsequently, these seed teachers trained more than 400 medical personnel in Mongolia. To assess secular changes in acute HDV infection, we reviewed the registration data from the National Center for Communicable Disease (NCCD) in Mongolia between 2011 and 2021. Results: Among the 194 Mongolian patients, 108 had dual infection with hepatitis B virus (HBV) and HDV, while 86 had acute hepatitis B (AHB). Patients with HBV/HDV dual infections were older (28.6 years vs. 25.5 years, p=0.030) and had lower rates of positive hepatitis B e antigen in their sera, lower rates of serum HBV DNA exceeding 2000 IU/mL, and higher rates of having received dental treatment (59.4% vs. 40.5%, p=0.014) and injection therapy (64.2% vs. 44.0%, p=0.009) compared to those with AHB. Analysis of NCCD data revealed that new HDV infection cases were more prevalent between 2011 and 2015 (111.20 ± 29.79 cases/year) and decreased to 54.67 ± 27.34 cases/year between 2016 and 2021 (p=0.010). Conclusion: Dental treatment and injections were associated with a higher risk of acute HDV infections in Mongolia. Through collaborative efforts, the incidence rate of HDV infection has declined in recent years.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk factors associated with hepatitis D virus infection and preventive strategies in Mongolia

Su,

Ochirkhuree,

Namdag

et al. 2024

Journal of the Chinese Medical Association

Self Cite

View full text Add to dashboard Cite

show abstract

“…Preventing the reuse of syringes can significantly reduce the incidence of HCV infections caused by unsafe injections ( 24 ). In addition, dental procedures, tattoos, and manicure and pedicure services are high-risk factors for HCV infection ( 25 , 26 ). Therefore, preventing the widespread transmission of HCV among high-risk individuals is an important strategy to reduce the burden of LCDHC.…”

Section: Discussionmentioning

confidence: 99%

Burden of liver cancer due to hepatitis C from 1990 to 2019 at the global, regional, and national levels

Wei,

Ouyang,

Huang

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundLiver cancer due to hepatitis C (LCDHC) is one of the leading causes of cancer-related deaths worldwide, and the burden of LCDHC is increasing. We aimed to report the burden of LCDHC at the global, regional, and national levels in 204 countries from 1990 to 2019, stratified by etiology, sex, age, and Sociodemographic Index.MethodsData on LCDHC were available from the Global Burden of Disease, Injuries, and Risk Factors (GBD) study 2019. Numbers and age-standardized mortality, incidence, and disability-adjusted life year (DALY) rates per 100,000 population were estimated through a systematic analysis of modeled data from the GBD 2019 study. The trends in the LCDHC burden were assessed using the annual percentage change.ResultsGlobally, in 2019, there were 152,225 new cases, 141,810 deaths, and 2,878,024 DALYs due to LCDHC. From 1990 to 2019, the number of incidences, mortality, and DALY cases increased by 80.68%, 67.50%, and 37.20%, respectively. However, the age-standardized incidence, mortality, and DALY rate had a decreasing trend during this period. In 2019, the highest age-standardized incidence rates (ASIRs) of LCDHC were found in high-income Asia Pacific, North Africa and the Middle East, and Central Asia. At the regional level, Mongolia, Egypt, and Japan had the three highest ASIRs in 2019. The incidence rates of LCDHC were higher in men and increased with age, with a peak incidence in the 95+ age group for women and the 85–89 age group for men in 2019. A nonlinear association was found between the age-standardized rates of LCDHC and sociodemographic index values at the regional and national levels.ConclusionsAlthough the age-standardized rates of LCDHC have decreased, the absolute numbers of incident cases, deaths, and DALYs have increased, indicating that LCDHC remains a significant global burden. In addition, the burden of LCDHC varies geographically. Male and older adult/s individuals have a higher burden of LCDHC. Our findings provide insight into the global burden trend of LCDHC. Policymakers should establish appropriate methods to achieve the HCV elimination target by 2030 and reducing the burden of LCDHC.

show abstract

“…In a more recent nationwide serosurvey performed in Mongolia in 2022, which included 10,040 participants from 10 to 64 years old, the prevalence was anti-HCV 8.9%, HBsAg 4.3%, and anti-HDV 4.8%. More than 60% of affected participants were unaware of having HBV or HCV infection, and 99% were unaware of their HDV-positive status [ 6 ]. In 2021, retrospective point-of-care testing in 251 HBsAg-positive serum samples from adults in Inner Mongolia detected anti-HDV in 13.4%, with detectable HDV RNA in 97% [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Community Strategy for Hepatitis B, C, and D Screening and Linkage to Care in Mongolians Living in Spain

Palom,

Almandoz,

Madejón

et al. 2023

Viruses

View full text Add to dashboard Cite

Mongolia has one of the highest viral hepatitis infection (B, C, and D) rates in the world. The aims of this study were to increase awareness of this disease and promote viral hepatitis screening in the Mongolian community living in Spain. Through a native community worker, Mongolian adults were invited to a community program consisting of an educational activity, an epidemiological questionnaire, and rapid point-of-care testing for hepatitis B and C. In those testing positive, blood extraction was performed to determine serological and virological parameters. In total, 280 Mongolians were invited to the program and 222 (79%) attended the event: 139 were women (63%), mean age was 42 years, and 78 (35%) had viral hepatitis risk factors. Testing found 13 (5.8%) anti-HCV-positive individuals, 1 with detectable HCV RNA (0.5%), 8 HBsAg-positive (3.6%), and 7 with detectable HBV DNA (3.1%). One additional individual had HBV/HCV co-infection with detectable HBV DNA and HCV RNA. Two subjects had hepatitis B/D co-infection (0.9%). The knowledge questionnaire showed a 1.64/8-point (20.5%) increase in correct answers after the educational activity. In summary, a viral hepatitis community program was feasible and widely accepted. It increased awareness of this condition in the Mongolian community in Spain and led to linkage to care in 22 participants, 50% of whom were unaware of their infection.

show abstract

Hepatitis B, C, and D Virus Infection among Population Aged 10–64 Years in Mongolia: Baseline Survey Data of a Nationwide Cancer Cohort Study

Cited by 4 publications

References 26 publications

Risk factors associated with hepatitis D virus infection and preventive strategies in Mongolia

Risk factors associated with hepatitis D virus infection and preventive strategies in Mongolia

Burden of liver cancer due to hepatitis C from 1990 to 2019 at the global, regional, and national levels

Community Strategy for Hepatitis B, C, and D Screening and Linkage to Care in Mongolians Living in Spain

Contact Info

Product

Resources

About