Hepatic Manifestations of Systemic Disorders

Gordon, Stuart C.; Patel, Hemal K.

doi:10.1002/9781119950509.ch9

Cited by 2 publications

(2 citation statements)

References 159 publications

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“…Determining the etiology of ALF is critical for guiding treatment but can be especially challenging in cases of malignant infiltrative disease. Symptoms and laboratory findings of ALF are nonspecific; however, a complete history should give some indication of possible malignant etiology, such as a history of B-symptoms or unexplained weight loss [10]. Physical exam may show lymphadenopathy or hepatosplenomegaly.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation

Hafner

Eaton²

2020

Cureus

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Liver involvement by non-Hodgkin's lymphoma is common in late stage disease but rarely results in severe hepatic dysfunction. Here, we discuss a case of acute liver failure (ALF) with severe lactic acidosis in a 75-year-old female with diffuse large B-cell lymphoma (DLBCL). The patient was admitted with nausea, fevers, and mild acidosis. Although radiographic imaging did not demonstrate any liver abnormality, the patient soon developed signs of ALF along with severe lactic acidosis. Despite initiation of chemotherapy, the patient deteriorated quickly and was ultimately put on comfort measures. This case highlights an uncommon manifestation of DLBCL and suggests that an accelerated timeline for beginning chemotherapy may be warranted in patients with high clinical suspicion of secondary hepatic lymphoma.

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Section: Discussionmentioning

confidence: 99%

Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation

Hafner

Eaton²

2020

Cureus

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“…DH is more common in the immunocompromised host and extreme of ages manifesting with high-grade fever, fatigue, weight loss, hepatosplenomegaly, and lymphadenopathy. Liver involvement presents with elevation of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, all of which were seen in this case [ 9 ]. Diagnostic tests include blood culture (gold standard), antigen detection, polymerase chain reaction assays, and direct microscopic examination of specimens, such as bronchial aspirates, bone marrow biopsy, or peripheral blood smear [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis

Columbus-Morales

Maahs

Husain

et al. 2020

Case Reports in Hepatology

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Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by a pathologic immune dysregulation resulting in extreme inflammation. Clinical manifestations are varied but can include severe multiorgan failure and death. HLH has been associated with malignancies, autoimmune diseases, and infections, such as histoplasmosis. Histoplasmosis commonly has subclinical manifestations but can also present in its disseminated form. We present the case of an immunocompromised patient with worsening liver function caused by hepatic histoplasmosis that later triggered HLH with severe multiorgan dysfunction.

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Hepatic Manifestations of Systemic Disorders

Cited by 2 publications

References 159 publications

Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation

Acute Liver Failure With Severe Lactic Acidosis Secondary to Infiltrative Diffuse Large B-Cell Lymphoma: An Imaging-Negative Presentation

A Case of Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis

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