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“…These 4‐ and 1.5‐fold increases in insulin infusion rate in obese type 2 diabetic patients and obese non‐diabetic patients resulted in 6.0‐ and 3.0‐fold increases in plasma insulin concentrations. This reflects most likely a decreased hepatic insulin clearance associated with obesity (10, 11). The plasma insulin concentrations attained were consequently significantly higher in obese type 2 diabetic patients and in obese non‐diabetic subjects than in healthy subjects.…”
Section: Discussionmentioning
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“…These 4‐ and 1.5‐fold increases in insulin infusion rate in obese type 2 diabetic patients and obese non‐diabetic patients resulted in 6.0‐ and 3.0‐fold increases in plasma insulin concentrations. This reflects most likely a decreased hepatic insulin clearance associated with obesity (10, 11). The plasma insulin concentrations attained were consequently significantly higher in obese type 2 diabetic patients and in obese non‐diabetic subjects than in healthy subjects.…”
Section: Discussionmentioning
“…These two processes maintain the hyperinsulinemia, and continue to promote energy storage. Hyperinsulinemia may also be exacerbated by decreased hepatic insulin clearance [160]. On possible contributor to the development of insulin resistance is the "fast food" epidemic of Western civilization, particularly the consumption of fructose [161,162].…”
Section: Insulin Dynamic Disordersmentioning
“…Escobar et al . demonstrated improved markers of insulin resistance, as well as relative weight loss, after 10 week of PSMF, in 8‐ to 18‐year‐olds, P < 0.05 81 . Figueroa‐Colon et al .…”
Section: Dietary Interventionsmentioning