2010
DOI: 10.1111/j.1472-8206.2010.00887.x
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Abstract: Indomethacin (IM), a non-steroidal anti-inflammatory drug, has the capacity to induce hepatic and renal injuries when administrated systemically. The aim of this study is to assess the IM absorption from complexed forms when orally administered to rats, by means of a comparative evaluation of its capacity to induce hepatic and renal injury in different forms, namely IM acid, IM sodium salt or IM complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), using freeze- and spray-drying methods. A total of 135 Wistar… Show more

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Cited by 7 publications
(7 citation statements)
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“…The inflammation mediated pain trigger the induction of pro-inflammatory cytokines and activates several signaling pathways such as NF-κB, MAPKs etc. Currently, several therapeutic approaches are employed to treat the inflammatory pain such as NSAIDs and opioids [43]. The chronic use of NSAIDs such as aspirin can cause the GIT ulceration, while the prolonged use of opioids is related with the development of tolerance, dependence and respiratory depression [4447].…”
Section: Discussionmentioning
confidence: 99%
“…The inflammation mediated pain trigger the induction of pro-inflammatory cytokines and activates several signaling pathways such as NF-κB, MAPKs etc. Currently, several therapeutic approaches are employed to treat the inflammatory pain such as NSAIDs and opioids [43]. The chronic use of NSAIDs such as aspirin can cause the GIT ulceration, while the prolonged use of opioids is related with the development of tolerance, dependence and respiratory depression [4447].…”
Section: Discussionmentioning
confidence: 99%
“…Nonsteroidal anti-inflammatory drugs are a widely clinically used class of anti-inflammatory and analgesic drugs. However, they may induce liver toxicity and/or stomach lesions. , Therefore, it is important to determine whether a novel molecule with potential therapeutic use as an anti-inflammatory and analgesic also induces similar side effects to currently used drugs. To compare the effect of compound 1 with indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), mice were treated daily with 1 (30 mg/kg, ip, 5% Tween 80 diluted in saline) or indomethacin (positive control, 2.5 mg/kg, ip, diluted in Tris/HCl buffer) for 7 days, which is a common time period of anti-inflammatory treatment .…”
Section: Resultsmentioning
confidence: 99%
“…On the other hand, treatment with indomethacin induced a significant increase of AST and ALT plasma levels in a similar manner to previous reports. 27,28 There is evidence that po treatment with indomethacin or other cyclooxygenase inhibitors (e.g., acetylsalicylic acid) induces gastric mucosa tolerance, described as showing no detectable gastric mucosal lesions concomitant with an increase in polymorphonuclear cell infiltrate as determined by myeloperoxidase (MPO) activity. 30 In agreement with that, the positive control indomethacin induced a significant increase of MPO activity in the stomach tissue compared to group treated with vehicle (Figure 8).…”
mentioning
confidence: 99%