Hepatic and renal protective effects of quercetin in ferrous sulfate-induced toxicity

Abstract

Iron is a vitally important element for the maintenance of health in living organisms. But, iron overload can be toxic. This study investigated the protective efficacy of quercetin against ferrous sulfate-induced oxidative stress, hepato-and nephrotoxicity in rats. There were five experimental groups (n = 7): Sham (distilled water, 1 ml/day for 14 days, i.p.), Quer (quercetin, 50 mg/kg/day for 14 days, i.p.), DMSO (dimethyl sulfoxide 1%, 1 ml i.p.), Fe (ferrous sulfate, 30 mg/kg/day for 14 days, i.p.), Fe+Quer (ferrous sulfate, 30 mg/kg/day for 14 days; quercetin, 50 mg/kg/day for 11 days from fourth day of ferrous sulfate injection). Blood, 24-h urine and tissue samples were collected at the end of experiment. Quercetin prevented ferrous sulfate-induced hepatotoxicity and nephrotoxicity as indicated by decreased activities of serum hepatic marker enzymes and decreased serum bilirubin concentration, higher levels of serum triglyceride, cholesterol, glucose, albumin and total protein, as well as higher creatinine clearance and lower fractional excretion of sodium. Besides, quercetin decreased malondialdehyde levels and histological damages in the liver and kidney of Fe group as compared with sham, DMSO and Quer groups. The protective effect of quercetin relies, at least partially, on its antioxidative effect which leads to decreased lipid peroxidation as well as iron-chelating property.

High Dietary Organic Iron Supplementation Decreases Growth Performance and Induces Oxidative Stress in Broilers

“…ALT is usually confined to liver cells, and is more specific than AST as a biomarker of liver damage, since AST is present in various organs, such as the kidneys, heart, muscles, brain, and lungs [44]. In the present study, ALT and AST activities were increased in broilers supplemented with 800 mg Fe/kg, indicating that high Fe exposure may cause broiler liver damage to a certain extent, which is in agreement with the results reported by Gholampour and Saki [45]. Total protein (TP) is vital for the maintenance of homoeostasis in broilers.…”

“…Both TP and ALB contents in the blood are considered markers of liver function that reflect protein synthesis [47]. TP and ALB levels decrease in rats under ferrous sulfate-induced oxidative stress conditions [45,48]. In the current study, TP content was not affected by Fe supplementation; however, serum ALB levels increased in broilers fed with 400 mg Fe/kg.…”

Role of Flavonoids in the Treatment of Iron Overload

“…Gholampour et al ( Gholampour and Saki, 2019 ) found that quercetin could inhibit hepatorenal toxicity induced by ferrous sulfate and reduce the degree of liver and renal tissue injury in rats. Glei et al (2002) confirmed through experiments that quercetin might reduce the risk of colon cancer by protecting the oxidative damage to DNA induced by iron.…”

Respiratory RNA Viruses: How to Be Prepared for an Encounter with New Pandemic Virus Strains

“…Quercetin has all these properties. In addition to its antioxidant effects, e.g., chelation of metals of variable valence (Gholampour and Saki, 2019), stimulation of the expression of antioxidant enzymes (Chen et al, 2017), a direct reduction of free radicals of fatty acid residues of phospholipids and oxidized forms of vitamin E (Chepur and et al, 2020;Ozgen et al, 2016), quercetin in the micromolar concentration range inhibits the activity of serine proteinases (Xue et al, 2017;Jo et al, 2019) and shields the active center of HA of the influenza-A virus (Wu et al, 2015), which gives it a wide range of antiviral effects (Zakaryan et al, 2017). methyl]amino]cyclohexanol hydrochloride (as ambroxol or lazolvan) is also gaining attention as an antiviral adjunct (Yang et al, 2002;Yamaya et al, 2014).…”