Hepatic Adverse Drug Reactions

Aithal, Guruprasad P.; Larrey, Dominique

doi:10.1002/9781118820186.ch35

Cited by 1 publication

(1 citation statement)

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“…This process which provides a structure and objectivity has been termed 'causality assessment' and it has become the standard method for the evaluation of suspected DILI. A number of DILI specific causality assessment methods have been developed over the past decades, however, those based on the decision tree model or Bayesian model, although based on sound principles, 264 have not been formally validated.…”

Section: Evidence: Level 4 (Case Series)mentioning

confidence: 99%

EASL Clinical Practice Guidelines: Drug-induced liver injury

Andrade¹,

Aithal²,

Bjõrnsson³

et al. 2019

Journal of Hepatology

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715

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Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, available herbs and dietary supplements with hepatotoxic potential, the ability of the condition to present with a variety of clinical and pathological phenotypes and the current absence of specific biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of awareness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.

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Section: Evidence: Level 4 (Case Series)mentioning

confidence: 99%