Hepatic Abnormalities Identified on Abdominal Computed Tomography at Diagnosis of Uveal Melanoma

Abstract

To determine the prevalence of hepatic abnormalities identified during abdominal computed tomography (CT) performed within 1 month of the diagnosis of primary uveal melanoma.Methods: Retrospective review of CT reports generated within 1 month following diagnosis of uveal melanoma in 91 patients at Memorial Sloan-Kettering Cancer Center, New York, New York, from 2004 to 2009.Results: Of 198 patients reviewed, 91 (46%) had a CT scan within 1 month of uveal melanoma diagnosis; 1 or more hepatic abnormalities were identified in 50 of these patients (55%). Abnormalities included 38 focal (13 solitary, 25 multiple) and 15 diffuse (11 partial, 4 complete) lesions. Six patients had hepatic lesions suspected to be metastatic melanoma, but this was confirmed in only 3. Lesions suspected to be metastases were more

Initial PET/CT Staging for Choroidal Melanoma: AJCC Correlation and Second Nonocular Primaries in 333 Patients

“…Our study found a positive predictive value of 100% when PET/CT revealed abnormal FDG uptake in the liver. This ratio might not be as high in a larger population of patients, but still reflects the low false-positive findings of PET/CT for screening of liver metastases, thus avoiding a major drawback of conventional screening procedures such as US or CT (22, 23).…”

Initial PET/CT Staging for Choroidal Melanoma: AJCC Correlation and Second Nonocular Primaries in 333 Patients

“…Our study found a positive predictive value of 100% when PET/CT revealed abnormal FDG uptake in the liver. This ratio might not be as high in a larger population of patients, but still reflects the low false-positive findings of PET/CT for screening of liver metastases, thus avoiding a major drawback of conventional screening procedures such as US or CT (22, 23).…”

Interdisciplinary Surveillance of Ocular Melanomas: Experiences in a German Tertiary Centre

“…Although metastasis screenings after uveal melanoma give the patient prognostic in-formation and a possible feeling of safety [18, 26 -28], mention must be made of the potential disadvantages of such diagnostics. The risk of false-negative and false-positive screening examinations (and the resulting invasive diagnostics) must be weighed against the possibility of prolonging survival [18,29,30]. Further- more, gamma radiation (e.g.…”

Characterization of Computed Tomography Scan Abnormalities in Patients With Biopsy-Proven Hepatic Metastases From Uveal Melanoma

“…Of these, 6 patients exhibited lesions suspicious for metastatic melanoma, although metastatic disease was subsequently confirmed in only 3 patients (3%). 14 From that study, we discovered that CT scan abnormalities exist in patients with uveal melanoma, even in the absence of metastatic disease.…”

Initial PET/CT Staging for Choroidal Melanoma: AJCC Correlation and Second Nonocular Primaries in 333 Patients

“…Our study found a positive predictive value of 100% when PET/CT revealed abnormal FDG uptake in the liver. This ratio might not be as high in a larger population of patients, but still reflects the low false-positive findings of PET/CT for screening of liver metastases, thus avoiding a major drawback of conventional screening procedures such as US or CT (22, 23).…”

Interdisciplinary Surveillance of Ocular Melanomas: Experiences in a German Tertiary Centre

“…Although metastasis screenings after uveal melanoma give the patient prognostic in-formation and a possible feeling of safety [18, 26 -28], mention must be made of the potential disadvantages of such diagnostics. The risk of false-negative and false-positive screening examinations (and the resulting invasive diagnostics) must be weighed against the possibility of prolonging survival [18,29,30]. Further- more, gamma radiation (e.g.…”

Characterization of Computed Tomography Scan Abnormalities in Patients With Biopsy-Proven Hepatic Metastases From Uveal Melanoma

“…Of these, 6 patients exhibited lesions suspicious for metastatic melanoma, although metastatic disease was subsequently confirmed in only 3 patients (3%). 14 From that study, we discovered that CT scan abnormalities exist in patients with uveal melanoma, even in the absence of metastatic disease.…”

Initial PET/CT Staging for Choroidal Melanoma: AJCC Correlation and Second Nonocular Primaries in 333 Patients

“…Our study found a positive predictive value of 100% when PET/CT revealed abnormal FDG uptake in the liver. This ratio might not be as high in a larger population of patients, but still reflects the low false-positive findings of PET/CT for screening of liver metastases, thus avoiding a major drawback of conventional screening procedures such as US or CT (22, 23).…”

Interdisciplinary Surveillance of Ocular Melanomas: Experiences in a German Tertiary Centre

“…Although metastasis screenings after uveal melanoma give the patient prognostic in-formation and a possible feeling of safety [18, 26 -28], mention must be made of the potential disadvantages of such diagnostics. The risk of false-negative and false-positive screening examinations (and the resulting invasive diagnostics) must be weighed against the possibility of prolonging survival [18,29,30]. Further- more, gamma radiation (e.g.…”

Characterization of Computed Tomography Scan Abnormalities in Patients With Biopsy-Proven Hepatic Metastases From Uveal Melanoma

“…Of these, 6 patients exhibited lesions suspicious for metastatic melanoma, although metastatic disease was subsequently confirmed in only 3 patients (3%). 14 From that study, we discovered that CT scan abnormalities exist in patients with uveal melanoma, even in the absence of metastatic disease.…”