Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats

Xia, Lixin; Wang, Shuo; Jiang, Zhiwen; Chi, Jinhua; Yu, Shu‐Qin; Li, Hongjian; Zhang, Yijie; Li, Lihua; Zhou, Changren; Liu, Wanshun; Han, Baoqin

doi:10.1016/j.carbpol.2021.117965

Cited by 63 publications

(36 citation statements)

References 36 publications

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“…Failure to haemostasis in time might lead to a lack of oxygen supply, subsequent damage to organs and even life-threatening conditions [277]. The haemostatic activity of MPs dressings is usually achieved by utilising the activity of MPs and their derivatives, as copolymers with other haemostatic materials, and by optimising the coagulation environment [60, [278][279][280]. Some MPs, especially CS, alginate and carrageenan, have excellent haemostatic properties [173,281].…”

Section: Development Of Activities-enhanced Mps Wound Dressingsmentioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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Section: Development Of Activities-enhanced Mps Wound Dressingsmentioning

confidence: 99%

Marine Polysaccharides for Wound Dressings Application: An Overview

et al. 2021

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“…Aldehyde-containing polymers are chosen for their specific properties in relation to desired applications. For example, oxidized hyaluronic acid (HA) was grafted on CMCS to form a hydrogel for wound dressing purposes [ 82 ]. Both polymers displayed hemostatic properties, facilitating platelets aggregation and activating red blood cells.…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…Despite being commercially available, in-house synthesis of CMCS remains frequent [ 82 ]. The initial procedure developed by Liu et al in 2000 involved the nucleophilic substitution of monochloroacetic acid in aqueous NaOH/ i PrOH, which favored the selective O-carboxymethylation [ 92 ].…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…Other parameters such as low temperature [ 93 ] or careful pH control [ 94 ] were reported to influence the selectivity between O- and N-carboxymethylation. Apart from applications in cancer therapy research [ 93 , 95 ], CMCS was recently used in more diverse applications, such as hemostatic material [ 82 ] or antioxidant hydrogel for drug release or tissue engineering [ 31 ].…”

Section: Strategies For Covalent Functionalizationmentioning

confidence: 99%

“…SEM can give essential insights into structure porosity, pore size, and roughness degree of hydrogels, nano/micro-fibers, and NPs based on CS [ 31 , 43 ]. The roughness degree is particularly important in applications such as wound healing, where cell attachment and proliferation has to be favored [ 82 , 102 ], or in food packaging, where smooth surfaces are preferred [ 50 ]. SEM is also a method of choice to observe and measure the pores of CS composites and molecular organic framework (MOF) [ 130 , 175 ].…”

Section: Characterization Of Cs-based Materialsmentioning

confidence: 99%

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Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chemical modifications via covalent conjugation and non-covalent interactions, which are designed to further improve the properties of interest. This review aims at presenting the broad range of functionalization strategies reported over the last five years to reflect the state-of-the art of CS derivatization. We start by describing covalent modifications performed on the CS backbone, followed by non-covalent CS modifications involving small molecules, proteins, and metal adjuvants. An overview of CS-based systems involving both covalent and electrostatic modification patterns is then presented. Finally, a special focus will be given on the characterization techniques commonly used to qualify the composition and physical properties of CS derivatives.

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Bio‐Inspired Self‐Healing Hydrogel for Fast Hemostasis and Accelerated Wound Healing of Gastric Ulcers

Wen,

Li,

Jiang

et al. 2024

Adv Funct Materials

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Gastric ulcers accompanied by acute or chronic bleeding represent a significant risk of fatality. However, the development of effective strategies for achieving rapid hemostasis and wound healing in gastric ulcer bleeding represents a formidable challenge. To address this challenge, thrombin‐derived C‐terminal peptide (TCP‐25) is employed as a targeted agent, and it is incorporated into two novel injectable and biocompatible carboxymethyl chitosan (CMCs) hydrogels via Schiff's base reaction. The TCP‐25 peptide hydrogels display optimal adaptability within the distinctive gastrointestinal microenvironment, demonstrating a balance of acid resistance and degradation, along with controlled release and bioactivity, and good bio‐adhesive properties. Both in vitro and in vivo reveal that the hydrogel achieves rapid hemostasis. In an ethanol‐induced gastric ulcer model in rats, it demonstrates that the hydrogel effectively inhibits gastric ulcer bleeding by 92% within 24‐h, exhibiting efficacy that surpasses that of omeprazole medicine, a commonly used clinical treatment. This enhanced performance is attributed to the synergistic effects of the CMCs hydrogel and TCP‐25 peptide in effectively achieving hemostasis, inhibiting bacterial growth, and promoting gastric wound healing in acute or chronic bleeding gastric ulcers. Consequently, the present work offers promising clinical applications for rapid hemostasis and wound healing in gastric ulcers.

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Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats

Cited by 63 publications

References 36 publications

Marine Polysaccharides for Wound Dressings Application: An Overview

Marine Polysaccharides for Wound Dressings Application: An Overview

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

Bio‐Inspired Self‐Healing Hydrogel for Fast Hemostasis and Accelerated Wound Healing of Gastric Ulcers

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