Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction

Tombul, Temel; Atbaş, Çiğdem; Anlar, Ömer

doi:10.1016/j.jocn.2004.06.013

Cited by 60 publications

(50 citation statements)

References 34 publications

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“…When BNP and D-dimer were combined, the positive predictive value of cardioembolic stroke was 70%. D-Dimer has been associated with cardioembolic stroke in other studies, with Ageno et al reporting a D-Dimer level >2.0 ug/mL to be predictive of cardioembolic stroke with specificity of 93.2% and sensitivity of 59.3% [36,37]. A more recent study confirms these findings [38].…”

Section: Biomarkers Of Ischemic Stroke Etiologymentioning

confidence: 72%

Blood Biomarkers of Ischemic Stroke

2011

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This review provides a summary of the protein and RNA biomarkers that have been studied for the diagnosis and assessment of ischemic stroke. Many of the biomarkers identified relate to the pathophysiology of ischemic stroke, including ischemia of CNS tissue, acute thrombosis and inflammatory response. These biomarkers are summarized by their intended clinical application in ischemic stroke including diagnosis, prediction of stroke severity and outcome, and stratification of patients for stroke therapy. Among the biomarkers discussed are recent whole genome studies using RNA expression profiles to diagnose ischemic stroke and stroke etiology. Though many candidate blood based biomarkers for ischemic stroke have been identified, none are currently used in clinical practice. With further well designed study and careful validation, the development of blood biomarkers to improve the care of patients with ischemic stroke may be achieved.

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Section: Biomarkers Of Ischemic Stroke Etiologymentioning

confidence: 72%

Blood Biomarkers of Ischemic Stroke

2011

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“…Plasmin splits the fibrin into FDP and D-dimers when the coagulation and fibrinolytic system is activated. A number of studies have shown that D-dimer, C-reactive protein, and other markers of hemostatic activation associate with a stroke diagnosis 5,18,19,[21][22][23]28,31,35,39) and with progression and death in acute ischemic stroke 5,6,10,30,44) . The report by Laskowitz et al 22) suggests that a biomarker panel may add valuable and time-sensitive diagnostic information to early stroke evaluation and rapid identification of patients with suspected stroke, which would expand the availability of time-limited treatment strategies.…”

Section: Treatmentmentioning

confidence: 99%

Correlation between Serum D-Dimer Level and Volume in Acute Ischemic Stroke

Park

Koh

Choi

2011

J Korean Neurosurg Soc

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“…Limited data are available on coagulation markers very early after symptom onset, as the majority of previous studies were performed >12 h after symptom onset [3,5,6,7,8,10,11,12,13,14]. D-dimer levels have been shown to be associated with cardioembolic strokes [4,6,7,8,9,10,12,14], yet their significance in acute stroke remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

D-Dimers Predict Stroke Subtype when Assessed Early

Isenegger¹,

Meier

Lämmle

et al. 2009

Cerebrovasc Dis

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Background:Early classification of ischemic stroke subtype is important for secondary stroke prevention and may guide further investigations. Methods: Levels of coagulation activation [fibrinopeptide A (FPA), prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT)] and fibrinolysis activation [plasmin-α₂-antiplasmin complex (PAP), D-dimers] markers were measured in 98 consecutive patients with a first-ever acute ischemic stroke admitted within 12 h after symptom onset. Results: Median age was 67 years and 44% were women. Median time from symptom onset to blood sampling was 4 h. Stroke subtype was classified as ‘cardioembolic’ (54%), ‘large-artery atherosclerosis’ (11%), ‘small-vessel disease’ (5%), ‘other determined’ (9%) or ‘undetermined etiology’ (20%). Patients with cardioembolic stroke suffered more often from coronary artery disease than patients with other stroke etiologies (40 vs. 22%, p = 0.019). There were no differences in age, sex, stroke severity, time to blood sampling, frequency of hypertension, diabetes mellitus or current smoking. D-dimers (medians) were higher in patients with cardioembolic strokes than in those with other etiologies (615 vs. 322 μg/l, p < 0.001). No differences in F1+2, FPA, TAT or PAP levels were found. After multivariate analysis, higher D-dimer levels remained independently associated with cardioembolic stroke (p = 0.022). When measured within 6 h, D-dimers below 300 μg/l excluded cardioembolic stroke with a sensitivity of 100% and a specificity of 52%. Conclusions: Low D-dimer levels in the first few hours make a cardioembolic stroke unlikely, and may be useful to guide further investigations. Other coagulation markers were not useful in differentiating between different stroke etiologies.

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Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction

Cited by 60 publications

References 34 publications

Blood Biomarkers of Ischemic Stroke

Blood Biomarkers of Ischemic Stroke

Correlation between Serum D-Dimer Level and Volume in Acute Ischemic Stroke

D-Dimers Predict Stroke Subtype when Assessed Early

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