2016
DOI: 10.3201/eid2208.151905
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Abstract: Clinicians should be aware of hemolysis in malaria patients with anemia who were given these drugs.

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Cited by 42 publications
(25 citation statements)
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References 16 publications
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“…In the absence of malaria parasites, free iron bioactivation of the endoperoxide bridge of artemisinin drugs can be used to modulate its effects (Conran, 2014;Krishna et al, 2004;Meshnick et al, 1989;Meshnick et al, 1993;Muhia et al, 1994;Tangnitipong et al, 2012). Delayed hemolysis in AS group follows a pattern similar to that reported in malaria infected persons (Arguin, 2014;Boillat et al, 2015;Chavada et al, 2015;Conran, 2014;Jauréguiberry et al, 2014;Kurth et al, 2016;Lee et al, 2015;Rehman et al, 2014;Rolling et al, 2015;WHO, 2013), although no anemia was recorded throughout this study.…”
Section: Discussionsupporting
confidence: 59%
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“…In the absence of malaria parasites, free iron bioactivation of the endoperoxide bridge of artemisinin drugs can be used to modulate its effects (Conran, 2014;Krishna et al, 2004;Meshnick et al, 1989;Meshnick et al, 1993;Muhia et al, 1994;Tangnitipong et al, 2012). Delayed hemolysis in AS group follows a pattern similar to that reported in malaria infected persons (Arguin, 2014;Boillat et al, 2015;Chavada et al, 2015;Conran, 2014;Jauréguiberry et al, 2014;Kurth et al, 2016;Lee et al, 2015;Rehman et al, 2014;Rolling et al, 2015;WHO, 2013), although no anemia was recorded throughout this study.…”
Section: Discussionsupporting
confidence: 59%
“…Shortened survival and removal of pitted erythrocytes explains only part of hemolysis in presence of malaria infection (Arguin, 2014;Jauréguiberry et al, 2014;Kurth et al, 2016;Rolling et al, 2015), unparasitized red blood cells are also cleared (Newton et al, 2001). Increased splenic clearance and lysis of the erythrocytes is also attributed to altered symmetry of phospholipid layer and reduced red cell deformability due to (Cooke et al, 2004;Nuchsongsin et al, 2007;Park et al, 2008;Pasvol et al, 1992).…”
Section: Discussionmentioning
confidence: 99%
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“…We suggest that drug-induced pitting should be evaluated early in the development of new generations of antimalarial molecules such as spiroindolones [11], which have an effect on ring circulating forms. This would help better grasp their mode of action in vivo, which helps predict the risk of posttreatment hemolysis observed in severe [4,[12][13][14] and more recently in uncomplicated malaria [9,15]. In the context of artemisinin resistance in Southeast Asia characterized by slow parasite clearance, a specific study on the role of pitting may explain how parasites initially escape clearance mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…Auftreten einer zeitverzögerten Hämolyse ist insbesondere nach der Gabe von Artesunate i. v. relevant, welches zur Therapie der komplizierten Malaria verabreicht wird[15] und kann jedoch auch bei einer oralen Therapie mit ACTs eine Rolle spielen[16]. Die endgültige Beurteilung der klinischen Relevanz dieses Phänomens steht jedoch aus.…”
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