Hemoglobin sensor based on external gold-coated photonic crystal fiber

Kiroriwal, Monika; Singal, Poonam; Sharma, Mohit; Singal, Abhinandan

doi:10.1016/j.optlastec.2021.107817

Cited by 14 publications

(5 citation statements)

References 30 publications

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“…Table 4 shows some of the best sensors of recent papers compared with the proposed sensor. Compared to [26,28,33], the proposed diabetes sensor has a higher AS, and compared to [27][28][29][30][31][32][33], it has a higher WS, which indicates the high sensitivity and unique performance of the proposed sensor.…”

Section: Simulation Results and Discussionmentioning

confidence: 98%

“…where K 0 is the wave propagation number in the free space (k 0 = 2π/λ), λ means the operating wavelength and Im(n eff ) means the imaginary part of the effective mode index. The WS of the proposed sensor is obtained from [33] WS = ∆λ ∆n a (nm…”

Section: Design and Analysis Of The Structurementioning

confidence: 99%

“…Haider et al [32] proposed multi-analyte detection based on integrated internal and external sensing approach; this sensor shows a maximum WS of 12 000 nm RIU −1 . Kiroriwal et al [33] designed external gold coated PCF hemoglobin sensor with a maximum AS of 2080.16 RIU −1 and an average WS of 4500 nm RIU −1 at RI of 1.38. Zhang et al [34] proposed a dual-D-shape sensor, in which the maximum WS is up to 12 600 nm RIU −1 in the RI range of 1.33-1.37.…”

Section: Introductionmentioning

confidence: 99%

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Design and numerical analysis of a highly sensitive nano-layer coated photonic crystal fiber biosensor

2023

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In this paper, a highly sensitive diabetes detection sensor based on photonic crystal fiber-gold plasmonic material is designed, proposed and analyzed. In this sensor, the application of a gold thin film increases the operating wavelength range (400 nm–1200 nm). The analyte, which is the cell, is placed outside the sensor and makes it easy to fabricate. The proposed sensor detects healthy and diabetic cells based on the refractive indices. Moreover, full-transistor modeling is presented to detect the probability of diabetes. In this model, healthy persons, persons with a low risk of diabetes and persons with a high risk of diabetes are diagnosed. Numerical results show that the proposed biosensor has a maximum amplitude sensitivity of 2127.7 RIU−1, amplitude resolution of 4.69 × 10−6 RIU, maximum wavelength sensitivity of 21 000 nm RIU−1 and wavelength resolution of 4.76 × 10−7 RIU.

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Section: Simulation Results and Discussionmentioning

confidence: 98%

Section: Design and Analysis Of The Structurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design and numerical analysis of a highly sensitive nano-layer coated photonic crystal fiber biosensor

2023

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“…On the other hand, the emergence of photonic crystal fibers (PCFs) resolves these problems by offering small sensor sizes and flexible and diverse design characteristics. PCF has been applied in many fields, such as bandwidth communication, thin film optics [17], fiber lasers [18], medical diagnosis [2,19], biochemical analysis [20,21], spectroscopy, and optical sensing [22,23]. Many PCF sensor properties, such as effective refractive index, confinement loss, mode area, and dispersion, can be effectively controlled by changing the air hole arrangement, pitch, and size of PCF structure parameters.…”

Section: Introductionmentioning

confidence: 99%

A High-Sensitivity Fiber Biosensor Based on PVDF-Excited Surface Plasmon Resonance in the Terahertz Band

Zhang,

Yao,

Guang

et al. 2023

Photonics

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In this paper, a D-type photonic crystal fiber (PCF) with Zeonex material as the substrate and polyvinylidene fluoride (PVDF) material as the surface plasmon resonance (SPR) excitation layer is proposed for biosensing in the terahertz (THz) band. Analyzed with a finite element method, the proposed biosensor has shown excellent sensing properties for analyte refractive indices ranging from 1.32 to 1.45. With a maximum sensor resolution of 8.40 × 10−7 refractive index unit (RIU) and a figure of merit of 39.42 RIU−1, the maximum wavelength sensitivity and amplitude sensitivity can reach 335.00 μm/RIU and −66.01 RIU−1, respectively. A ±2% fabrication tolerance analysis is also performed on the biosensor to prove its practical feasibility. We conclude that our proposed PCF biosensor utilizing PVDF-excited SPR can provide high sensitivity, and thus a compact, label-free, and convenient solution for biomedical liquid sensing in the THz band.

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“…The knowledge about blood properties play s a key role in determining of the patient's health condition [1][2][3]. From this point of view, modern medicine requires the development of new methods and sen sor st ru ctures designed for measurement of blood properties in clu d ing oxidation level and hemoglobin concentration [4][5][6][7]. Th e integrated optics structures based on a planar wavegu id e and a grating coupler offer attractive possibilities of application as a sensor structure for measurement of selected properties of biological liquids, including b lo o d properties -oxidation and concentration of haemoglo bin [7][8][9][10].…”

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confidence: 99%

Analysis of ridges and grooves shape in grating coupler for optimization of integrated optics sensor structures.

Struk¹

2022

Photon.Lett.PL

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The paper presents a theoretical analysis of a sensor structure based on a planar waveguide and grating coupler designed to determine selected physical properties of blood – hemoglobin concentration and oxidation level. In particular analysis were focused on optimization of selected geometrical properties of grating coupler (shape of ridges and grooves) to obtain maximum efficiency of uncoupling of light from the sensor structure. The analysis were carried out for three type of ridges and grooves shape in grating coupler: rectangular, triangular and sinusoidal. Full Text: PDF ReferencesI. . Singh, A.Weston, A. Kundur, G. Dobie, Haematology Case Studies with Blood Cell Morphology and Pathophysiology; Elsevier: Amsterdam, The Netherlands, (2017). DirectLink P. Jarolim, M. Lahav, SC. Liu, J. Palek, "Effect of hemoglobin oxidation products on the stability of red cell membrane skeletons and the associations of skeletal proteins: correlation with a release of hemin", Blood 76, 10 (1990). CrossRef E. Beutler, J. Waalen, "The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?", Blood 107, 5 (2006). CrossRef M. Kiroriwal, P. Singal M. Sharma, A. Singal, "Hemoglobin sensor based on external gold-coated photonic crystal fiber", Optics & Laser Technology 149, 107817 (2022). CrossRef A. A. Boiarski, J. R. Busch, B. S. Bhullar, R. W. Ridgway, V. E. Wood, "Integrated optic sensor with macro-flow cell", Proc. SPIE Integrated Optics and Microstructures 1793 (1993). CrossRef L. Cheng, S. Mao, Z. Li, Y. Han and H. Y. Fu, "Grating Couplers on Silicon Photonics: Design Principles, Emerging Trends and Practical Issues", Micromachines 11, 666 (2020). CrossRef P. Struk, "Design of an Integrated Optics Sensor Structure Based on Diamond Waveguide for Hemoglobin Property Detection", Materials 12, 175 (2019). CrossRef P. Struk, "Numerical analysis of integrated photonics structures for hemoglobin sensor application", Phot. Lett. Poland 12, 2 (2020). CrossRef P.V. Lambeck, "Integrated optical sensors for the chemical domain", Meas. Sci. Technol. 17, (2006). CrossRef W. Lukosz, "Integrated optical chemical and direct biochemical sensors", Sens. Actuators B Chem 29 (1995). CrossRef P. Struk, T. Pustelny, K. Gołaszewska,E. Kaminska, M.A. Borysiewicz, M. Ekielski, A. Piotrowska, "Hybrid photonics structures with grating and prism couplers based on ZnO waveguides", Opto-Electron. Rev. 21, (2013). CrossRef P. Struk, "Design of an integrated optics sensor structure for hemoglobin property detection", Proc. SPIE 11204, (2019). CrossRef OptiFDTD Technical Background and Tutorials - Finite Difference Time Domain Photonics Simulation Software, Optiwave Systems Inc. (2008). DirectLink K. Yee, "Cutoff Frequencies of Eccentric Waveguides", IEEE Transactions 14, 3 (1966). CrossRef

show abstract

Hemoglobin sensor based on external gold-coated photonic crystal fiber

Cited by 14 publications

References 30 publications

Design and numerical analysis of a highly sensitive nano-layer coated photonic crystal fiber biosensor

Design and numerical analysis of a highly sensitive nano-layer coated photonic crystal fiber biosensor

A High-Sensitivity Fiber Biosensor Based on PVDF-Excited Surface Plasmon Resonance in the Terahertz Band

Analysis of ridges and grooves shape in grating coupler for optimization of integrated optics sensor structures.

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