Hemoglobin levels in high altitude Tibetan natives of northwest Nepal

Larrick, James W.; Topgyal, Sonam

doi:10.1007/bf02189000

Cited by 3 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 3 describes the mean hemoglobin concentration in the subset of 18 samples residing in the narrow range of altitudes from 3,400 to 4,000 m. The four crosses re resent four subsamples and the 95% conmeasurement and hemoglobin concentrations. The subsample cate ories are the same as those in Figure 2: I n dean mining communities (n =4) (Cosio, 1973;Hultgren, 1965;Hurtado et al, 19451, Andean urban samples (n=4) Beall et al, ms a; Moret et al, 1972;Arnaud et al, 1979;Tufts et al, 1988, Andean rural sam les (n=3) (present study; layan rural (n=6) (Larrick and Topgyal, 1985;Adams and Strang, 1975;Adams and Shrestha, 1974;Samaja et al, 1979;Beall and Reichsman, 1984). A fifth subsam le is and Sun, 1990).…”

Section: Risk Factors For Anemia In Himalayan Samplesmentioning

confidence: 93%

Variation in hemoglobin concentration among samples of high‐altitude natives in the Andes and the Himalayas

Beall

Brittenham

Macuaga

et al. 1990

American J Hum Biol

View full text Add to dashboard Cite

This paper presents data on hemoglobin concentration in a rural Andean sample at 3,800-3,900 m and incorporates them into a review intended to evaluate possible sources of the range of variation in mean hemoglobin concentration among samples obtained at high altitude. Between 3,400 and 4,000 m, rural Himalayan highlanders average 1.4 gm/dl lower mean hemoglobin concentration than rural Andean highlanders. With respect to potential causes of anemia, it is concluded that the relatively low values of rural Himalyan populations are not explicable by lower hypoxic stress or different techniques of obtaining and analyzing blood samples and are probably not explicable by nutritional deficiency and disease. With respect to potential causes of polycythemia within Andean populations, it is concluded that the somewhat higher values of some mining and urban samples of Andean higlanders may not be due to the mining occupation per se but may be due partly to the inclusion of European and mestizo (with at most 500 years of high-altitude ancestry) along with Amerindian highlanders (with millenia of high-altitude ancestry) as well as to the inclusion of highlanders living well above their own habitual altitudes of residence. The Andean polycythemia is probably not due to obesity, high androgen levels, or frequent intermittent hypoxemia during sleep. The effect of heavy smoking cannot be evaluated. Further work on hematological adaptation to high altitude must pay special attention to sample characteristics.

show abstract

Section: Risk Factors For Anemia In Himalayan Samplesmentioning

confidence: 93%

Variation in hemoglobin concentration among samples of high‐altitude natives in the Andes and the Himalayas

Beall

Brittenham

Macuaga

et al. 1990

American J Hum Biol

View full text Add to dashboard Cite

show abstract

Detecting natural selection in high-altitude human populations

Beall

2007

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

Adaptations to Altitude: A Current Assessment

Beall

2001

Annu. Rev. Anthropol.

View full text Add to dashboard Cite

▪ Abstract The high-altitude Andean and Tibetan Plateaus offer natural experimental settings for investigating the outcome of the past action of evolution and adaptation as well as those ongoing processes. Both Andean and Tibetan high-altitude natives are descended from sea-level ancestors; thus both initially encountered chronic, lifelong high-altitude hypoxia with the same homeostatic “toolbox” that evolved at sea level for responding to brief and transient hypoxia. Yet now they differ phenotypically in many traits thought to be important for offsetting chronic high-altitude hypoxia. Compared on the basis of mean values of five traits, the characteristics of Tibetan high-altitude natives differ more than those of Andean high-altitude natives from the ancestral or unselected response to chronic hypoxia exhibited by acclimatized lowlanders. This suggests that different evolutionary processes have occurred in the two geographically separate areas, although it is not clear why or how those processes differed. Answers to those questions require better knowledge of the prehistory of human populations on the plateaus, as well as information on new phenotypes and the relationship between phenotype and genotype.

show abstract

Hemoglobin levels in high altitude Tibetan natives of northwest Nepal

Cited by 3 publications

References 8 publications

Variation in hemoglobin concentration among samples of high‐altitude natives in the Andes and the Himalayas

Variation in hemoglobin concentration among samples of high‐altitude natives in the Andes and the Himalayas

Detecting natural selection in high-altitude human populations

Adaptations to Altitude: A Current Assessment

Contact Info

Product

Resources

About