1972
DOI: 10.1182/blood.v40.6.812.812
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Abstract: The liver participates in the removal from the circulation of both damaged red blood cells (RBC) and plasma hemoglobin. The specific hepatic cell types involved in these processes have been identified by fractionation of rat liver into pure isolates of parenchymal and sinusoidal cells. After injection of 59Fe-labeled hemoglobin, 85%-95% of the radioactivity in the liver was associated with the parenchymal cells, regardless of whether the hemoglobin was bound to haptoglobin or was free in plasma. By contrast, 5… Show more

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Cited by 98 publications
(25 citation statements)
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“…In the event of hemolysis or of heme administered to porphyric patients (38,39), the regulation of heme uptake resulting from formation of heme-hemopexin complex may function to prevent flooding of the liver with amounts of heme that are potentially toxic. As discussed elsewhere (40-431, the tight binding of heme by hemopexin prevents the pro-oxidant activities of heme.…”
Section: Discussionmentioning
confidence: 99%
“…In the event of hemolysis or of heme administered to porphyric patients (38,39), the regulation of heme uptake resulting from formation of heme-hemopexin complex may function to prevent flooding of the liver with amounts of heme that are potentially toxic. As discussed elsewhere (40-431, the tight binding of heme by hemopexin prevents the pro-oxidant activities of heme.…”
Section: Discussionmentioning
confidence: 99%
“…It was first documented in the early 1970s that both nonparenchymal cells and hepatocytes convert heme to bile pigments 19 : Removal and degradation of senescent erythrocytes is a function of Kupffer cells, whereas free hemoglobin is catabolized mainly by hepatocytes. 19 It was postulated also that cytochrome P450 heme is a substrate for HO specifically in hepatocytes.…”
Section: Distribution Of Ho and Microtopographic Basis For Co-mediatementioning
confidence: 99%
“…It was first documented in the early 1970s that both nonparenchymal cells and hepatocytes convert heme to bile pigments 19 : Removal and degradation of senescent erythrocytes is a function of Kupffer cells, whereas free hemoglobin is catabolized mainly by hepatocytes. 19 It was postulated also that cytochrome P450 heme is a substrate for HO specifically in hepatocytes. 20 Recently, the distribution of HO-1 and HO-2 in rat liver was examined by immunohistology using specific monoclonal antibodies, with the finding that the two isozymes have distinct topographic patterns 21 : HO-1, the inducible form, is prominent in Kupffer cells, whereas the constitutive HO-2 is most abundant in hepatocytes.…”
Section: Distribution Of Ho and Microtopographic Basis For Co-mediatementioning
confidence: 99%
“…The regulation of HO-1 gene expression in normal liver cell cultures has to date not been described. This issue is of importance, since hepatocytes are chiefly responsible for the uptake and catabolism of heme from the circulating plasma [25].…”
mentioning
confidence: 99%