Hemodynamics instability score in chronic fatigue syndrome and in non-chronic fatigue syndrome

Fractal analysis and recurrence quantification analysis of heart rate and pulse transit time for diagnosing chronic fatigue syndrome

“…In our results, the FD provided three out of five independent predictors that characterized the CFS group. Thus, the importance of fractal analysis in the characterization of the cardiovascular reactivity was substantiated and results of previous studies, which utilized a different technique [11,12,24,25], were confirmed.…”

“…Studies of the HIS comprised 70 patients with CFS, 73 patients with non-CFS chronic fatigue, and 41 patients with fibromyalgia. The sensitivity of the HIS for the diagnosis of CFS in these studies was 91.4 % and the overall specificity was 85.1 % [11,12,25]. The high sensitivity and specificity of the FRAS and HIS for CFS improves on the moderate sensitivity and poor specificity of classical autonomic testing for CFS [2][3][4][5][6][7][8][9][10].…”

Assessment of cardiovascular reactivity by fractal and recurrence quantification analysis of heart rate and pulse transit time

“…The HIS also discerned the particular reactivity of CFS patients from the cardiovascular reactivities of other patient groups, which may confound the diagnosis of CFS, such as patients with fibromyalgia, non-CFS fatigue, and neurogenic syncope. [28][29][30] The HIS identified a distinctive cardiovascular reactivity in patients with essential hypertension. 7 Thus, the correlation of results obtained by both the FRAS and the HIS methods supports the authenticity of reactivity phenotypes.…”

“…In theses studies, which comprised 70 patients with CFS, 73 patients with non-CFS chronic fatigue, and 41 patients with fibromyalgia, the sensitivity of the HIS for the diagnosis of CFS was 91.4% and the overall specificity was 85.1%. [28][29][30] The high sensitivity and specificity of the HIS for CFS improves on the moderate sensitivity and poor specificity of classical autonomic testing for CFS. [31][32][33] Based on these data, it appears that the HIS can reinforce the clinician's diagnosis by providing objective criteria to the assessment of CFS, which, until now, could only be subjectively inferred.…”

Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease

“…In non-hepatic diseases, fatigue has been associated with the presence of autonomic nervous system dysfunction manifest as significant hypotension [9,22,42,43] with impaired cerebral auto-regulation suggested as a plausible central mechanism, whereby relative hypotension and reduced cerebral oxygenation may lead to fatigue [46]. Studies performed using ambulatory blood pressure monitoring have demonstrated strong temporal links between fatigue expression and periods of hypotension in cardiac failure [11,13] and Gulf war veterans [8,14].…”