Hemodynamics and oxygen metabolism in the pig during long-term hypothermia: comparison of 2 pH strategies

Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs

“…However, the rise in PVR, which was most prominent in the Constant PPA group, is consistent with previous observations made in various species including rats, pigs, and dogs (8, 17, 21, 30). At variation from isolated lungs that are perfused at constant flow or constant pressure, intact organisms adjust perfusion to the demands of the local tissues in an interaction between peripheral sensors and the central nervous system (31).…”

Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs

“…However, the rise in PVR, which was most prominent in the Constant PPA group, is consistent with previous observations made in various species including rats, pigs, and dogs (8, 17, 21, 30). At variation from isolated lungs that are perfused at constant flow or constant pressure, intact organisms adjust perfusion to the demands of the local tissues in an interaction between peripheral sensors and the central nervous system (31).…”

Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans

“…2005). Skin‐surface cooling increases PAP and decreases pulmonary vascular conductance in anaesthetized pigs (Kornberger et al . 1995).…”

The role of preservation solution on acid–base regulation during machine perfusion of kidneys

“…By contrast, the pH‐stat regulation process is encountered in hibernating animals where an arterial pH of 7.4 is maintained regardless of systemic temperature and where metabolism continues even at a 5°C body temperature. Alpha‐stat pH regulation helps to maintain a beneficial constant degree of alkalinity between the extracellular and intracellular compartments during cooling (36, 39).…”

Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs

“…However, the rise in PVR, which was most prominent in the Constant PPA group, is consistent with previous observations made in various species including rats, pigs, and dogs (8, 17, 21, 30). At variation from isolated lungs that are perfused at constant flow or constant pressure, intact organisms adjust perfusion to the demands of the local tissues in an interaction between peripheral sensors and the central nervous system (31).…”

Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans

“…2005). Skin‐surface cooling increases PAP and decreases pulmonary vascular conductance in anaesthetized pigs (Kornberger et al . 1995).…”

The role of preservation solution on acid–base regulation during machine perfusion of kidneys

“…By contrast, the pH‐stat regulation process is encountered in hibernating animals where an arterial pH of 7.4 is maintained regardless of systemic temperature and where metabolism continues even at a 5°C body temperature. Alpha‐stat pH regulation helps to maintain a beneficial constant degree of alkalinity between the extracellular and intracellular compartments during cooling (36, 39).…”

Effects of Constant Flow vs. Constant Pressure Perfusion on Fluid Filtration in Severe Hypothermic Isolated Blood-Perfused Rat Lungs

“…However, the rise in PVR, which was most prominent in the Constant PPA group, is consistent with previous observations made in various species including rats, pigs, and dogs (8, 17, 21, 30). At variation from isolated lungs that are perfused at constant flow or constant pressure, intact organisms adjust perfusion to the demands of the local tissues in an interaction between peripheral sensors and the central nervous system (31).…”

Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans

“…2005). Skin‐surface cooling increases PAP and decreases pulmonary vascular conductance in anaesthetized pigs (Kornberger et al . 1995).…”

The role of preservation solution on acid–base regulation during machine perfusion of kidneys

“…By contrast, the pH‐stat regulation process is encountered in hibernating animals where an arterial pH of 7.4 is maintained regardless of systemic temperature and where metabolism continues even at a 5°C body temperature. Alpha‐stat pH regulation helps to maintain a beneficial constant degree of alkalinity between the extracellular and intracellular compartments during cooling (36, 39).…”