Hemodynamic Study During Induction of General Anaesthesia With Propofol Using Priming Principle

Abstract

Propofol is a popular intravenous induction agent, hypotension is known complication of propofol, hence priming technique is adopted to reduce the induction dose and hence reduce the incidence of hypotension. Current study is undertaken to evaluate the haemodynamic changes with bolus dose and priming dose of propofol. METHODS: the study population is divided into two groups -PRIMING GROUP: After calculating the total dose of Propofol induction agent (2mg/kg) 20% was injected as bolus and remaining drug is administered till the loss of eye lash reflux and verbal response at the rate of 30mg/10sec. NON PRIMING GROUP: intravenous injection of propofol bolus (2mg/kg) iv in 30 seconds was given. RESULT: A mean induction dose of Propofol required in priming group is 88.26mg and in non-priming group it is 106.28mg. Reduction in dose requirement in priming group is by 16.74%.Haemodynamic stability was better in non-priming group. Complications like apnoea, involuntary movements, were seen in both the groups. CONCLUSION: Induction dose of Propofol is reduced in priming group and there is greater fall of blood pressure compared to non-priming group, both groups had fewer side effects like apnoea and involuntary movements.