1999
DOI: 10.1001/jama.282.21.2035
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Atherosclerosis, the leading cause of death in the developed world and nearly the leading cause in the developing world, is associated with systemic risk factors including hypertension, smoking, hyperlipidemia, and diabetes mellitus, among others. Nonetheless, atherosclerosis remains a geometrically focal disease, preferentially affecting the outer edges of vessel bifurcations. In these predisposed areas, hemodynamic shear stress, the frictional force acting on the endothelial cell surface as a result of blood… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

78
2,272
5
60

Year Published

2004
2004
2019
2019

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 2,985 publications
(2,415 citation statements)
references
References 110 publications
78
2,272
5
60
Order By: Relevance
“…96 Arterial shear rates peak at 1640 s 21, 96 reaching 10 4 s 21, 58 in partly clogged coronary arterioles. The literature contains a significant number of reports [98][99][100][101][102][103][104][105][106][107] (and references therein) linking the haemodynamic stress generated on arterial walls during microcirculation, specifically in regions of relatively low shear stress, to the pathogenesis of atherosclerosis through the modulation of endothelial function. 108 A characteristic hallmark of this disease state is the deposition of amyloidlike protein aggregates as plaque on arterial walls.…”
Section: Implications In Physiology and Bioprocessingmentioning
confidence: 99%
“…96 Arterial shear rates peak at 1640 s 21, 96 reaching 10 4 s 21, 58 in partly clogged coronary arterioles. The literature contains a significant number of reports [98][99][100][101][102][103][104][105][106][107] (and references therein) linking the haemodynamic stress generated on arterial walls during microcirculation, specifically in regions of relatively low shear stress, to the pathogenesis of atherosclerosis through the modulation of endothelial function. 108 A characteristic hallmark of this disease state is the deposition of amyloidlike protein aggregates as plaque on arterial walls.…”
Section: Implications In Physiology and Bioprocessingmentioning
confidence: 99%
“…entrance of intramyocardial segments (Figure 2). SS is the frictional force exerted by the circulating blood onto the endothelial surface (20). It is defined as the product of the velocity gradient near the wall and the blood viscosity; this definition suggests that SS varies proportionally with flow.…”
Section: Role Of Tensile Stressmentioning
confidence: 99%
“…It is defined as the product of the velocity gradient near the wall and the blood viscosity; this definition suggests that SS varies proportionally with flow. Low and oscillatory SS are characterized by low time-averaged values (less than 1.5 N/m 2 ) and significant variations in direction and magnitude over short distances, and constitute major determinants of the localization, development and progression of atherosclerosis (20)(21)(22)(23)(24). Through complex mechanotransduction processes similar to those initiated by TS, coronary endothelium responds to low and oscillatory SS by adopting a vasoconstrictive (ET-1), proinflammatory (adhesion molecules and cytokines), pro-oxidative, growth-promoting and prothrombotic phenotype, ultimately acquiring a predisposition to atherosclerosis (16,20,24).…”
Section: Role Of Tensile Stressmentioning
confidence: 99%
See 1 more Smart Citation
“…The risk associated with immobility, by means of increasing blood stasis, affects not only those confined to bed but also those who remain in sedentary positions as a result of long periods of travel (6) and even computer use (7). Blood stasis is probably the main cause, acting through mechanisms such as red blood cell settling and is likely to cause vessel wall and blood chemistry changes through wall shear acting on endothelial cells (8,9). As such, mechanical DVT prophylaxis aims to increase venous blood velocity and return flow using devices such as compression stockings, intermittent pneumatic compression and electrical stimulation.…”
mentioning
confidence: 99%